| .SAT | Spatial Corp | CAD檔案 | ACIS SAT 3D Model File | Adobe Acrobat DC | Adobe Systems Incorporated |
| .SBL | Adobe Systems Incorporated | 圖形文件 | Shockwave Flash Object | Adobe Flash Player | Adobe Systems Incorporated |
| .SBX | Dream Design Entertainment Software | 壓縮檔案 | GLBasic Shoebox File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .SCM | Gimpel Software | 插件檔案 | GIMP Script-Fu Script | ExtendScript Toolkit (ESTK) | Adobe Systems Incorporated |
| .SCSS | Sublime HQ Pty Ltd | 網絡文件 | Syntactically Awesome Stylesheets Syntax Data | Adobe Dreamweaver | Adobe Systems Incorporated |
| .SCT | Scitex | 光柵圖像檔案 | Scitex Continuous Tone File | Adobe Photoshop | Adobe Systems Incorporated |
| .SD0 | Adobe Systems Incorporated | 相機原始文件 | Dali Raw Image | Adobe Lightroom CC | Adobe Systems Incorporated |
| .SD1 | Adobe Systems Incorporated | 相機原始文件 | Dali Raw Image | Adobe Lightroom CC | Adobe Systems Incorporated |
| .SEQU | Adobe Systems Incorporated | 設置檔案 | Adobe Acrobat Sequence File | Adobe Acrobat DC | Adobe Systems Incorporated |
| .SES | Adobe Systems Incorporated | 音頻檔案 | Audition Session File | Adobe Audition | Adobe Systems Incorporated |
| .SESSION | Dassault Systèmes | 三維圖像檔案 | CATIA 4 Session File | Adobe Acrobat DC | Adobe Systems Incorporated |
| .SGM | VBA Team | 遊戲檔案 | VisualBoyAdvance Saved Game | Adobe FrameMaker | Adobe Systems Incorporated |
| .SGML | Corel | 資料檔案 | Standard Generalized Markup Language File | Adobe FrameMaker | Adobe Systems Incorporated |
| .SHC | Adobe Systems Incorporated | 資料檔案 | Adobe Photoshop Contours File | Adobe Photoshop CC | Adobe Systems Incorporated |
| .SHH | Adobe Systems Incorporated | 設置檔案 | Adobe Photoshop Shadow/Highlight Settings | Adobe Photoshop CC | Adobe Systems Incorporated |
| .SHTM | Opera Software | 視頻檔案 | HTML Server Side Include File | Adobe Dreamweaver | Adobe Systems Incorporated |
| .SHTML | Sublime HQ Pty Ltd | 網絡文件 | Server Side Include HTML File | Adobe Dreamweaver | Adobe Systems Incorporated |
| .SITE | Adobe Systems Incorporated | 網絡文件 | GoLive Website Project File | Adobe GoLive | Adobe Systems Incorporated |
| .SIV | Adobe Systems Incorporated | 視頻檔案 | Silicon Imaging Video File | Adobe SpeedGrade | Adobe Systems Incorporated |
| .SKL | Autodesk, Inc. | 三維圖像檔案 | Maya Skeleton File | Adobe Authorware | Adobe Systems Incorporated |
| .SLDASM | Dassault Systèmes | CAD檔案 | SolidWorks Assembly File | Adobe Acrobat DC | Adobe Systems Incorporated |
| .SLDPRT | Dassault Systèmes | CAD檔案 | SolidWorks CAD Part File | Adobe Acrobat DC | Adobe Systems Incorporated |
| .SMP | MakeMusic, Inc. | 音頻檔案 | SmartMusic Performance File | Adobe Audition | Adobe Systems Incorporated |
| .SND | Open Source | 音頻檔案 | Sound File | Adobe Audition | Adobe Systems Incorporated |
| .SOL | Adobe Systems Incorporated | 設置檔案 | Flash Local Shared Object File | Adobe Flash Player | Adobe Systems Incorporated |
| .SOR | Adobe Systems Incorporated | 資料檔案 | Adobe Flash Media Server File System Object | Adobe Media Server | Adobe Systems Incorporated |
| .SPL | Microsoft Corporation | 系統檔案 | Windows Print Spool File | Adobe Flash Player | Adobe Systems Incorporated |
| .SR2 | Sony | 相機原始文件 | Sony RAW Image | Adobe Photoshop | Adobe Systems Incorporated |
| .SRF | NewTek | 三維圖像檔案 | LightWave Surface File | Adobe Photoshop | Adobe Systems Incorporated |
| .SRW | Samsung Electronics | 相機原始文件 | Samsung RAW Image | Adobe Photoshop Elements | Adobe Systems Incorporated |
| .SSI | Adobe Systems Incorporated | 開發商檔案 | Adobe Dreamweaver Server Side Include File | Adobe Dreamweaver | Adobe Systems Incorporated |
| .SSK | Adobe Systems Incorporated | 向量圖像檔案 | SmartSketch 95 Document | Adobe Flash Professional CC | Adobe Systems Incorporated |
| .STC | Adobe Systems Incorporated | 網絡文件 | Contribute Connection Key File | Adobe Contribute 6.5 | Adobe Systems Incorporated |
| .STD | Oracle Corporation | 向量圖像檔案 | Apache OpenOffice Drawing Template | Adobe Acrobat DC | Adobe Systems Incorporated |
| .STE | Adobe Systems Incorporated | 設置檔案 | Dreamweaver Site Settings File | Adobe Dreamweaver | Adobe Systems Incorporated |
| .STL | 3D Systems | CAD檔案 | Stereolithography File | Adobe Fireworks | Adobe Systems Incorporated |
| .STM | Microsoft Corporation | 資料檔案 | Exchange Streaming Media File | Adobe Dreamweaver | Adobe Systems Incorporated |
| .STN | ON1, Inc. | 向量圖像檔案 | Genuine Fractals Image | Adobe Photoshop | Adobe Systems Incorporated |
| .STP | Unknown Developer | 三維圖像檔案 | STEP 3D CAD File | Adobe RoboHelp | Adobe Systems Incorporated |
| .SVG | Nintendo | 遊戲檔案 | Saved Game File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .SVGZ | Adobe Systems Incorporated | 向量圖像檔案 | Compressed SVG File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .SWA | Adobe Systems Incorporated | 音頻檔案 | Shockwave Audio | Adobe Director | Adobe Systems Incorporated |
| .SWB | Adobe Systems Incorporated | 資料檔案 | Adobe Photoshop Data | Adobe Photoshop | Adobe Systems Incorporated |
| .SWC | Adobe Systems Incorporated | 開發商檔案 | Flex Components Archive | Adobe Animate CC 2017 | Adobe Systems Incorporated |
| .SWD | Adobe Systems Incorporated | 開發商檔案 | Flash Debug File | Adobe Flash Player | Adobe Systems Incorporated |
| .SWF | Adobe Systems Incorporated | 視頻檔案 | Shockwave Flash Movie | Adobe Animate CC 2017 | Adobe Systems Incorporated |
| .SWL | Macromedia | 圖形文件 | Alternate Macromedia Flash Format | Adobe Flash Player | Adobe Systems Incorporated |
| .SWT | Adobe Systems Incorporated | 視頻檔案 | Flash Generator Template | Adobe Flash Professional CC | Adobe Systems Incorporated |
| .SWZ | Adobe Systems Incorporated | 網絡文件 | Adobe Flash Player Cache File | Adobe Flash Player | Adobe Systems Incorporated |
| .SYN | Image-Line | 音頻檔案 | SimSynth Document | Adobe RoboHelp | Adobe Systems Incorporated |
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