| .R3D | Various Developers | 視頻檔案 | REDCODE Video File | Adobe Premiere Pro CC | Adobe Systems Incorporated |
| .RAF | Fuji Xerox | 相機原始文件 | Fuji RAW Image File | Adobe Photoshop Elements | Adobe Systems Incorporated |
| .RAW | Unknown Developer | 相機原始文件 | Raw Image Data File | Adobe Photoshop Elements | Adobe Systems Incorporated |
| .RDT | Adobe Systems Incorporated | 資料檔案 | Adobe Captivate RoboDemo Template File | Adobe Captivate | Adobe Systems Incorporated |
| .RF | Adobe Systems Incorporated | 資料檔案 | Adobe FrameMaker Document | Adobe FrameMaker | Adobe Systems Incorporated |
| .RFR | Adobe Systems Incorporated | 資料檔案 | Adobe Photoshop Frame Filter | Adobe Photoshop | Adobe Systems Incorporated |
| .RL4 | Various Developers | 光柵圖像檔案 | Bitmap Image File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .RL8 | Microsoft Corporation | 圖形文件 | Windows Bitmap Image | Adobe Photoshop | Adobe Systems Incorporated |
| .RLE | Various Developers | 光柵圖像檔案 | Run Length Encoded Bitmap | Adobe Photoshop Elements | Adobe Systems Incorporated |
| .RMD | Thomson Reuters Corporation | 資料檔案 | Reference Manager Data File | Adobe Premiere Pro CC | Adobe Systems Incorporated |
| .RMF | Valve | 遊戲檔案 | Hammer Rich Map Format | Adobe Acrobat DC | Adobe Systems Incorporated |
| .RPF | Rockstar Games | 遊戲檔案 | Grand Theft Auto Data File | Adobe After Effects | Adobe Systems Incorporated |
| .RPLN | Adobe Systems Incorporated | 插件檔案 | InDesign Required Plug-in File | Adobe InDesign | Adobe Systems Incorporated |
| .RSA | Various Developers | 不常見的文件 | RSA Certificate File | Adobe Photoshop Elements | Adobe Systems Incorporated |
| .RTA | Adobe Systems Incorporated | 資料檔案 | RoboHelp RTA Data File | Adobe RoboHelp | Adobe Systems Incorporated |
| .RTK | Adobe Systems Incorporated | 資料檔案 | Adobe RoboHelp Configuration File | Adobe RoboHelp | Adobe Systems Incorporated |
| .RVL | muvee | 視頻檔案 | Muvee Reveal X Project File | Adobe Revel | Adobe Systems Incorporated |
| .RWL | Leica Biosystems | 相機原始文件 | Leica D-Lux 4 RAW Image | Adobe Photoshop | Adobe Systems Incorporated |
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