| .SBN | ESRI | GIS文件 | ESRI Spatial Binary File | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SBX | Dream Design Entertainment Software | 压缩文件 | GLBasic Shoebox File | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SDC | Stardock Corporation | 备份文件 | Stardock Central Download Archive | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SDI | Intuit, Inc. | 数据文件 | QuickBooks Data File | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SDW | LizardTech | GIS文件 | MrSID World File | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SHP | Autodesk, Inc. | 3D图像文件 | AutoCAD Shape File | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SHX | Autodesk, Inc. | CAD文件 | AutoCAD Compiled Shape File | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SID | Valve | 游戏文件 | Steam Game Data Backup File | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SLD | ESRI (Environmental Systems Research Institute) | GIS文件 | Styled Layer Descriptor | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SML | ESRI | 开发者文件 | ARC/INFO Simple Macro Language File | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .STN | ON1, Inc. | 矢量图像文件 | Genuine Fractals Image | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .STYLE | Trimble Inc. | 设置文件 | SketchUp Style | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SXD | ESRI | GIS文件 | ArcScene Document | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
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