| .E3 | DPT Corp | Fişiere de jocuri | Think3 Thinkdesign CAD Document | ThinkDesign Suite | DPT Corp |
| .EA3 | Electronic Arts | Fişiere de jocuri | FIFA 2001 Game Data | FIFA 2001 | EA Sports |
| .EAC | Emurasoft, Inc. | Fişiere de jocuri | EmEditor Auto-Completion Data | EmEditor | Emurasoft, Inc. |
| .EBP | Jes-Soft | Fişiere de jocuri | Jes-Soft Sports Play Description | Jes-Soft Playbook | Jes-Soft |
| .EBZ | Intersystem Concepts | Fişiere de jocuri | Empire Builder Pronto Saved Game | Empire Builder Pronto | Intersystem Concepts |
| .ECL | Team Shanghai Alice | Fişiere de jocuri | Touhou Stage Script | Touhou ToolKit | Touhou Patch Center |
| .ECW | ESRI (Environmental Systems Research Institute) | Fişiere de jocuri | Enhanced Compression Wavelet Image | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .EDT | Adobe Systems Incorporated | Fişiere de jocuri | Adobe eBook Download Settings | Adobe Digital Editions | Adobe Systems Incorporated |
| .EES | Sierra Entertainment | Fişiere de jocuri | Empire Earth Scenario Data | Empire Earth | Sierra Entertainment |
| .EFF | The Hotline Group | Fişiere de jocuri | eFileFolders File Format | eFileFolders | The Hotline Group |
| .EFT | Cay Horstmann | Fişiere de jocuri | ChiWriter High Resolution Screen Font | ChiWriter | Cay Horstmann |
| .EFX | j2 Global, Inc. | Fişiere de jocuri | eFax Document | j2 Global Communications eFax | j2 Global, Inc. |
| .EGM | Pangea Software, Inc. | Fişiere de jocuri | Pangea Enigmo Custom Game Data | Pangea Software Enigmo | Pangea Software, Inc. |
| .EGT | EagleGet | Fişiere de jocuri | EagleGet Temporary File | EagleGet | EagleGet |
| .EIC | Nitro Games | Fişiere de jocuri | East Indian Company Save Game File | East India Company | Nitro Games |
| .EK6 | Open Source | Fişiere de jocuri | Generation 6 Pokémon Save File | PKHeX | Open Source |
| .EKV | Valve | Fişiere de jocuri | Left 4 Dead Game Data | Left 4 Dead | Valve |
| .EKX | Open Source | Fişiere de jocuri | Encrypted 3DS Pokémon Save File | PKHeX | Open Source |
| .ELF | Nintendo | Fişiere de jocuri | Nintendo Wii Game File | Dolphin (emulator) | Dolphin Emulator Project |
| .ELM | Open Source | Fişiere de jocuri | Eternal Lands Map File | Eternal Lands | Open Source |
| .EMI | Blitwise Productions | Fişiere de jocuri | Pocket Tanks Emitter File | Pocket Tanks | Blitwise Productions |
| .EMM | MindMaple Inc. | Fişiere de jocuri | MindMaple Map | MindMaple | MindMaple Inc. |
| .ENC | Smith Micro Software | Fişiere de jocuri | Encoded Data File | Smith Micro StuffIt Deluxe | Smith Micro Software |
| .END | Corel | Fişiere de jocuri | CorelDRAW Arrow-head Definition Data | CorelDRAW Graphics Suite | Corel |
| .ENG | Unknown Developer | Fişiere de jocuri | Chess Engine | ChessMaster | Ubisoft Blue Byte |
| .ENV | Adobe Systems Incorporated | Fişiere de jocuri | Adobe Dictionary Data File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .EPC | Sumo Digital Ltd. | Fişiere de jocuri | Doctor Who Game Data File | BBC Doctor Who: The Adventure Games | Sumo Digital Ltd. |
| .EPK | LG Electronics | Fişiere de jocuri | LG Firmware Package | epk2extract | openlgtv |
| .ERB | Open Source | Fişiere de jocuri | Ruby ERB Script | Microsoft Notepad | Microsoft Corporation |
| .ERF | BioWare | Fişiere de jocuri | BioWare Entity Resource File | BioWare Neverwinter Nights | BioWare |
| .ERP | Future Games | Fişiere de jocuri | Alter Ego Game Archive | Alter Ego | Future Games |
| .ES | Interscape | Fişiere de jocuri | ECHOSPEECH File | ECHOSPEECH | Interscape |
| .ESG | Pangea Software, Inc. | Fişiere de jocuri | Enigmo Saved Game File | Pangea Software Enigmo | Pangea Software, Inc. |
| .ESI | Open Source | Fişiere de jocuri | Escape Level Index File | Escape | Open Source |
| .ESM | Bethesda Softworks | Fişiere de jocuri | Bethesda Softworks Master File | Bethesda Softworks TES Construction Set | Bethesda Softworks |
| .ESN | Epic Games | Fişiere de jocuri | Unreal Engine Language Localization | Unreal Tournament | Epic Games |
| .ESP | Bethesda Softworks | Fişiere de jocuri | Elder Scrolls Plugin File | Bethesda Softworks TES Construction Set | Bethesda Softworks |
| .ESS | Bethesda Softworks | Fişiere de jocuri | The Elder Scrolls Saved Game | Skyrim VR | Bethesda Softworks |
| .ESX | Xactware Solutions | Fişiere de jocuri | Xactimate Insurance Claims Estimate | Xactimate | Xactware Solutions |
| .EU4 | Paradox Development Studio | Fişiere de jocuri | Europa Universalis IV Saved Game | Europa Universalis IV | Paradox |
| .EUR | Capcom | Fişiere de jocuri | Monster Hunter Freedom Unite EU Region Saved Game | Monster Hunter Freedom Unite | Capcom |
| .EVP | Miracle Castle | Fişiere de jocuri | Talisman Online Game Data | Talisman Online | Miracle Castle |
| .EWL | Green Eclipse | Fişiere de jocuri | EclipseCrossword Word List File | Green Eclipse EclipseCrossword | Green Eclipse |
| .EXC | Lionhead Studios | Fişiere de jocuri | Black & White Zone File | Lionhead Studios Black and White | Lionhead Studios |
| .EXL | SysTools Solutions | Fişiere de jocuri | Export Lister File | SysTools Export Notes | SysTools Solutions |
| .EXS | Apple | Fişiere de jocuri | EXS Instrument | Apple Logic Pro | Apple |
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