| .SPADES | Unknown Developer | Fişiere de date | Unknown Apple II File. (found On Golden Orchard Apple II CD Rom) | Atom | GitHub, Inc. |
| .SPARSE | Apple | Fişiere de date | Golden Orchard Apple II CD Rom File | Apple OS X | Apple |
| .SPB | Samsung Electronics | Fişiere de date | Samsung Kies Phonebook File | Samsung Kies | Samsung Electronics |
| .SPH | National Institute of Standards and Technology (NIST) | Fişiere de date | NIST SPHERE Audio File | SoX | Open Source |
| .SPJ | IBM | Fişiere de date | SPSS Production Job File | IBM SPSS | IBM |
| .SPL | Microsoft Corporation | Fişiere de date | Windows Print Spool File | Microsoft Windows | Microsoft Corporation |
| .SPLIT | Incredible Bee Ltd | Fişiere de date | Archiver Split File | 7-Zip | Igor Pavlov |
| .SPM | Corel | Fişiere de date | Corel WordPerfect Data | Corel WordPerfect | Corel |
| .SPO | Electronic Arts | Fişiere de date | Spore Saved Game | Electronic Arts Spore | Electronic Arts |
| .SPOP | Opera Software | Fişiere de date | InterTrust SPOP File | Internet Explorer | Microsoft Corporation |
| .SPP | Serif | Fişiere de date | Serif PhotoPlus Picture File | PhotoPlus | Serif |
| .SPRITES | Apple | Fişiere de date | Golden Orchard Apple II CD Rom File | Apple OS X | Apple |
| .SPS | IBM | Fişiere de date | SPSS Program File | IBM SPSS | IBM |
| .SPV | IBM | Fişiere de date | SPSS Output Document | IBM SPSS | IBM |
| .SPW | Quantitative Software Management, Inc. | Fişiere de date | SLIM-Master Plan Workbook File | SLIM Suite | Quantitative Software Management, Inc. |
| .SPZ | Crestron Electronics | Fişiere de date | Creston SIMPL Windows Compiled Program | SIMPL Windows | Crestron Electronics |
| .SQ | Calerga Sarl | Fişiere de date | Sysquake Program | Sysquake | Calerga Sarl |
| .SQ7 | Daktronics | Fişiere de date | Daktronics Venus 7000 Electronic Sign Sequence Data | Venus 7000 Sports Display Controller | Daktronics |
| .SQD | SparkPath Technologies | Fişiere de date | Configuration Settings File | SP Debugger for SQR | SparkPath Technologies |
| .SQF | Bohemia Interactive | Fişiere de date | ArmA Script File | ArmA: Armed Assault | Bohemia Interactive |
| .SQR | Oracle Corporation | Fişiere de date | SQL Program File | Microsoft SQL Server | Microsoft Corporation |
| .SQUASHFS | Open Source | Fişiere de date | Squashfs File System File | 7-Zip | Igor Pavlov |
| .SR2 | Sony | Fişiere de date | Sony RAW Image | Adobe Photoshop | Adobe Systems Incorporated |
| .SRB | Open Source | Fişiere de date | XWE File | XWE | Open Source |
| .SRD | Sage | Fişiere de date | Sage Report Data File | Sage Instant Accounts | Sage |
| .SRE | Microsoft Corporation | Fişiere de date | Windows CE 5.0 File | Microsoft Windows CE Embedded | Microsoft Corporation |
| .SRF | NewTek | Fişiere de date | LightWave Surface File | LightWave 3D | NewTek |
| .SRG | Ketron | Fişiere de date | Ketron Single Registration File | Ketron Software | Ketron |
| .SRH | BMC | Fişiere de date | BMC Remedy AR System Server Saved Search | Unknown Software | Unknown Developer |
| .SRL | Procedimientos-Uno, S.L. | Fişiere de date | Arquitienda Local Database File | CFwin | iMventa Ingenieros |
| .SRN | Micro Focus International plc | Fişiere de date | Micro Focus Screen | Micro Focus Extra! | Micro Focus International plc |
| .SRO | Unknown Developer | Fişiere de date | MADCOW Multi-Site ATIS Data Collection Working Group Data | MADCOW (Multi-Site ATIS Data Collection Working Group) | Interscape |
| .SRQ | Microsoft Corporation | Fişiere de date | Microsoft Windows Server Unprocessed Request File | Microsoft Windows Server 2016 | Microsoft Corporation |
| .SRT | SourceForge | Fişiere de date | SubRip Subtitle File | VLC Media Player | VideoLAN |
| .SRW | Samsung Electronics | Fişiere de date | Samsung RAW Image | ACD Systems ACDSee | ACD Systems |
| .SRX | Sublime HQ Pty Ltd | Fişiere de date | SPARQL Query Results XML Format Result | Microsoft Notepad | Microsoft Corporation |
| .SS2 | Unknown Developer | Fişiere de date | Terrasoft SAS Program File | Unknown Software | Unknown Developer |
| .SS4 | MODRATEC | Fişiere de date | SigScribe4 Design File | SigScribe 4 | MODRATEC |
| .SSC | Microsoft Corporation | Fişiere de date | SourceSafe Status File | Microsoft Visual Studio | Microsoft Corporation |
| .SSD | Stardock Corporation | Fişiere de date | WindowBlinds Skin File List | WindowBlinds | Stardock Corporation |
| .SSG | ICLUBcentral Inc. | Fişiere de date | Investor's Toolkit Stock Selection Guide | Investor's Toolkit | ICLUBcentral Inc. |
| .SSL | Bethesda Softworks | Fişiere de date | Fallout Script | Fallout Script Editor | Jargo |
| .SSM | RealNetworks | Fişiere de date | Standard Streaming Metafile | RealPlayer | Realtime Technologies |
| .SSN | Samsung Electronics | Fişiere de date | Samsung Kies Notes Backup | Samsung Kies | Samsung Electronics |
| .SSP | Scala | Fişiere de date | Scala Server Page | Scalate | Open Source |
| .SSS | Stardock Corporation | Fişiere de date | WindowBlinds Substyle File | WindowBlinds | Stardock Corporation |
| .SST | Microsoft Corporation | Fişiere de date | Serialized Certificate Store File | Certificate Manager Tool | Microsoft Corporation |
| .SSU | Microsoft Corporation | Fişiere de date | SMS Hierarchy Manager Site Update | Microsoft Systems Management Server | Microsoft Corporation |
| .SSV | Seavus | Fişiere de date | Seavus Secure Project File | Seavus Project Viewer | Seavus |
| .SSX | IBM | Fişiere de date | IBM Rational XDE Data | Rational XDE | IBM |
| .ST0 | National Instruments | Fişiere de date | SPICE Status Data | Spice | National Instruments |
| .ST1 | Converge Horizons | Fişiere de date | DigiTitle Master Subtitle File | DigiTitle Master | Converge Horizons |
| .ST2 | National Instruments | Fişiere de date | SPICE Status Data | Spice | National Instruments |
| .ST3 | National Instruments | Fişiere de date | SPICE Status Data | Spice | National Instruments |
| .ST4 | Corel Corporation | Fişiere de date | Pinnacle Studio 400 Project File | Pinnacle Studio | Corel |
| .ST6 | XnSoft | Fişiere de date | SBIG CCD Camera Image | XnView MP | XnSoft |
| .ST7 | XnSoft | Fişiere de date | SBIG CCD Camera Image | XnView MP | XnSoft |
| .ST9 | XnSoft | Fişiere de date | SBIG CCD Camera Image | XnView MP | XnSoft |
| .STA | Dassault Systèmes | Fişiere de date | ABAQUS Status File | ABAQUS software suite | Dassault Systèmes |
| .STACK | Apple | Fişiere de date | Golden Orchard Apple II CD Rom File | Apple OS X | Apple |
| .STAGE1 | Apple | Fişiere de date | Golden Orchard Apple II CD Rom File | Apple OS X | Apple |
| .STAR | Apple | Fişiere de date | Golden Orchard Apple II CD Rom File | Apple OS X | Apple |
| .STARTUP | Apple | Fişiere de date | Golden Orchard Apple II CD Rom File | Apple OS X | Apple |
| .STATE | Microsoft Corporation | Fişiere de date | Windows Photo Gallery User Data | Windows Photo Gallery | Microsoft Corporation |
| .STATS | Open Source | Fişiere de date | FreeSurfer Statistics File | FreeSurfer | Open Source |
| .STATUS | Open Source | Fişiere de date | UDraw(Graph) File | UDraw(Graph) | Open Source |
| .STC | Adobe Systems Incorporated | Fişiere de date | Contribute Connection Key File | Adobe Contribute 6.5 | Adobe Systems Incorporated |
| .STD | Oracle Corporation | Fişiere de date | Apache OpenOffice Drawing Template | Apache OpenOffice | Apache Software Foundation |
| .STDF | Teradyne | Fişiere de date | Standard Test Data Format | Unknown Software | Unknown Developer |
| .STEGANO | Unknown Developer | Fişiere de date | Steganographic Image File | Unknown Software | Unknown Developer |
| .STF | Microsoft Corporation | Fişiere de date | Exchange 2000 Server Temporary File | Microsoft Exchange Server | Microsoft Corporation |
| .STI | Oracle Corporation | Fişiere de date | StarOffice Presentation Template | Apache OpenOffice | Apache Software Foundation |
| .STK | Peter Bone | Fişiere de date | Stickfigure Animator File | Pivot Animator (Pivot Stickfigure Animator) | Peter Bone |
| .STKX | DTLink Software | Fişiere de date | Personal Stock Streamer Portfolio File | Personal Stock Streamer | DTLink Software |
| .STL | 3D Systems | Fişiere de date | Stereolithography File | Creo Parametric 3D Modeling Software | PTC |
| .STM | Microsoft Corporation | Fişiere de date | Exchange Streaming Media File | Microsoft Exchange Server | Microsoft Corporation |
| .STORAGE | Apple | Fişiere de date | Golden Orchard Apple II CD Rom File | Apple OS X | Apple |
| .STORY | Storyist Software | Fişiere de date | Storyist Document | Storyist | Storyist Software |
| .STP | Unknown Developer | Fişiere de date | STEP 3D CAD File | CATIA | Dassault Systèmes |
| .STR | dBase, LLC | Fişiere de date | dBASE Structure List Object File | dBase | dBase, LLC |
| .STRING | IDM Computer Solutions | Fişiere de date | UltraEdit Data | UltraEdit | IDM Computer Solutions |
| .STT | Microsoft Corporation | Fişiere de date | Streets & Trips Map Template | Microsoft AutoRoute | Microsoft Corporation |
| .STU | Avid Technology | Fişiere de date | Pinnacle Studio Project | Pinnacle Studio | Corel |
| .STV | Unknown Developer | Fişiere de date | SofTV Authoring Data | Unknown Software | Unknown Developer |
| .STVPROJ | Microsoft Corporation | Fişiere de date | Microsoft Visual Studio Data File | Microsoft Visual Studio | Microsoft Corporation |
| .STW | Oracle Corporation | Fişiere de date | StarOffice Document Template | Apache OpenOffice | Apache Software Foundation |
| .STX | Unknown Developer | Fişiere de date | Scream Tracker Music Interface Kit File | CocoModX | Open Source |
| .STY | Jørgen Sørensen / Jososoft | Fişiere de date | Yamaha/Korg Keyboard Style | Style Fixer | Jørgen Sørensen / Jososoft |
| .STYKZ | Sons of Thunder | Fişiere de date | Stykz Animation | Sons of Thunder Stykz | Sons of Thunder |
| .SUA | Naviter | Fişiere de date | SeeYou Airspace Data | SeeYou | Naviter |
| .SUC | Interscape | Fişiere de date | Hello Engines! 2.1 Data | Hello Engines | Interscape |
| .SUI | Sean Maxwell | Fişiere de date | StarSplatter User Interface File | StarSplatter User Interface | Sean Maxwell |
| .SUJ | Open Source | Fişiere de date | Stacker Unlimited Job | Stacker Unlimited | Open Source |
| .SUM | AmsterCHEM | Fişiere de date | Scilab Unit Operation Model File | AmsterCHEM MATLAB CAPE-OPEN Unit Operation | AmsterCHEM |
| .SUPP | Apple | Fişiere de date | iOS Data File | Apple iOS | Apple |
| .SUS | SAP | Fişiere de date | SAP Transactionware GM POS Xpress Suspended Data | SAP BusinessObjects Business Intelligence | SAP |
| .SVCLOG | Microsoft Corporation | Fişiere de date | Microsoft Visual Studio Diagnostics Data | Microsoft Visual Studio | Microsoft Corporation |
| .SVD | Polytec | Fişiere de date | Scanning Vibrometer Data File | Polytec PSV Software | Polytec |
| .SVF | Joint Test Action Group | Fişiere de date | Serial Vector Format File | MicroStation | Bentley Systems |
| .SVN | Apache Software Foundation | Fişiere de date | Subversion Data File | Subversion | Apache Software Foundation |
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