| .R3D | Various Developers | Fişiere video | REDCODE Video File | Adobe Premiere Pro CC | Adobe Systems Incorporated |
| .RAF | Fuji Xerox | Fișiere imagine RAW | Fuji RAW Image File | Adobe Photoshop Elements | Adobe Systems Incorporated |
| .RAW | Unknown Developer | Fișiere imagine RAW | Raw Image Data File | Adobe Photoshop Elements | Adobe Systems Incorporated |
| .RDT | Adobe Systems Incorporated | Fişiere de date | Adobe Captivate RoboDemo Template File | Adobe Captivate | Adobe Systems Incorporated |
| .RF | Adobe Systems Incorporated | Fişiere de date | Adobe FrameMaker Document | Adobe FrameMaker | Adobe Systems Incorporated |
| .RFR | Adobe Systems Incorporated | Fişiere de date | Adobe Photoshop Frame Filter | Adobe Photoshop | Adobe Systems Incorporated |
| .RL4 | Various Developers | Fişiere de imagini rastru | Bitmap Image File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .RL8 | Microsoft Corporation | Fișiere grafice | Windows Bitmap Image | Adobe Photoshop | Adobe Systems Incorporated |
| .RLE | Various Developers | Fişiere de imagini rastru | Run Length Encoded Bitmap | Adobe Photoshop Elements | Adobe Systems Incorporated |
| .RMD | Thomson Reuters Corporation | Fişiere de date | Reference Manager Data File | Adobe Premiere Pro CC | Adobe Systems Incorporated |
| .RMF | Valve | Fişiere de jocuri | Hammer Rich Map Format | Adobe Acrobat DC | Adobe Systems Incorporated |
| .RPF | Rockstar Games | Fişiere de jocuri | Grand Theft Auto Data File | Adobe After Effects | Adobe Systems Incorporated |
| .RPLN | Adobe Systems Incorporated | Fişiere plugin | InDesign Required Plug-in File | Adobe InDesign | Adobe Systems Incorporated |
| .RSA | Various Developers | Fișiere neobișnuite | RSA Certificate File | Adobe Photoshop Elements | Adobe Systems Incorporated |
| .RTA | Adobe Systems Incorporated | Fişiere de date | RoboHelp RTA Data File | Adobe RoboHelp | Adobe Systems Incorporated |
| .RTK | Adobe Systems Incorporated | Fişiere de date | Adobe RoboHelp Configuration File | Adobe RoboHelp | Adobe Systems Incorporated |
| .RVL | muvee | Fişiere video | Muvee Reveal X Project File | Adobe Revel | Adobe Systems Incorporated |
| .RWL | Leica Biosystems | Fișiere imagine RAW | Leica D-Lux 4 RAW Image | Adobe Photoshop | Adobe Systems Incorporated |
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