| .S00 | Lithops Software | Ficheiros Compactados | ZipSplitter Part 1 Archive | ZipSplitter | Lithops Software |
| .S01 | Lithops Software | Ficheiros Compactados | ZipSplitter Part 2 Archive | Lithops Software ZipSplitter | Lithops Software |
| .S02 | Lithops Software | Ficheiros Compactados | ZipSplitter Part 3 Archive | Lithops Software ZipSplitter | Lithops Software |
| .S07 | Eugene Roshal | Ficheiros Compactados | Split Multi-volume RAR Compressed File | WinZip | Corel |
| .S09 | Eugene Roshal | Ficheiros Compactados | Split Multi-volume RAR Compressed File | WinZip | Corel |
| .S7Z | Igor Pavlov | Ficheiros Compactados | 7-Zip Compressed File | 7-Zip | Igor Pavlov |
| .SAR | Commodore International | Ficheiros Compactados | Saracen Paint Image | XnView MP | XnSoft |
| .SAZ | Microsoft Corporation | Ficheiros Compactados | Fiddler Session Archive ZIP Data | Fiddler | Microsoft Corporation |
| .SBC | Microsoft Corporation | Ficheiros Compactados | Office Accounting Company Shortcut File | Microsoft Office Accounting | Microsoft Corporation |
| .SBX | Dream Design Entertainment Software | Ficheiros Compactados | GLBasic Shoebox File | GLBasic | Dream Design Entertainment Software |
| .SCZ | OpenLimit SignCubes AG | Ficheiros Compactados | OpenLimit SignCubes Zip Container File | OpenLimit CC Sign | OpenLimit SignCubes AG |
| .SDA | Oracle Corporation | Ficheiros Compactados | StarOffice Drawing | Apache OpenOffice | Apache Software Foundation |
| .SDC | Stardock Corporation | Ficheiros Compactados | Stardock Central Download Archive | Stardock Central | Stardock Corporation |
| .SDK | Autodesk, Inc. | Ficheiros Compactados | AutoSketch Drawing | AutoSketch | Autodesk, Inc. |
| .SDN | Robert K. Jung | Ficheiros Compactados | Shareware Distributors Network File | ARJ Software JAR | Robert K. Jung |
| .SEA | Smith Micro Software | Ficheiros Compactados | Self-Extracting Archive | Smith Micro StuffIt Deluxe | Smith Micro Software |
| .SEN | Neyer Software LLC | Ficheiros Compactados | SenTest Data File | Neyer Software SenTest | Neyer Software LLC |
| .SEZ | Geoslope | Ficheiros Compactados | SEEP/W ZIP Compressed Data | SEEP/W | Geoslope |
| .SFARK | Unknown Developer | Ficheiros Compactados | Melody Machine Compressed SoundFont File | Awave Studio | FMJ-Software |
| .SFS | Open Source | Ficheiros Compactados | Squashfs File Archive | 7-Zip | Igor Pavlov |
| .SFX | Corel | Ficheiros Compactados | Windows Self-Extracting Archive | WinZip | Corel |
| .SH | Unknown Developer | Ficheiros Compactados | Bash Shell Script | Notepad++ | Don Ho |
| .SHA | Corel | Ficheiros Compactados | CorelDraw Shader File | CorelDRAW Graphics Suite | Corel |
| .SHAR | Unknown Developer | Ficheiros Compactados | Unix Shar Archive | shar | Unknown Developer |
| .SHK | Andy Nicholas | Ficheiros Compactados | ShrinkIt Compressed Apple II File Archive | ShrinkIt | Andy Nicholas |
| .SHR | Open Source | Ficheiros Compactados | Unix Shell Archive File | unshar | Open Source |
| .SIN | Big Huge Games | Ficheiros Compactados | Rise Of Nations Campaign Media File | Rise Of Nations | Big Huge Games |
| .SIT | Smith Micro Software | Ficheiros Compactados | StuffIt Archive | Smith Micro StuffIt Deluxe | Smith Micro Software |
| .SITX | Smith Micro Software | Ficheiros Compactados | StuffIt X Archive | Smith Micro StuffIt Deluxe | Smith Micro Software |
| .SLE | Sisulizer | Ficheiros Compactados | Sisulizer Package File | Sisulizer | Sisulizer |
| .SLP | Magix Software GmbH | Ficheiros Compactados | SpectraLayers Pro Project | SpectraLayers Pro | Magix Software GmbH |
| .SNAP | Erik Kunze | Ficheiros Compactados | ZX Spectrum Emulator Mirage Microdrive Snapshot | XZX-Pro | Erik Kunze |
| .SNB | Samsung Electronics | Ficheiros Compactados | S Note File (Old Version) | S Note | Samsung Electronics |
| .SOLITAIRETHEME8 | Eugene Roshal | Ficheiros Compactados | LoversLab Renamed RAR Archive | WinRAR | Eugene Roshal |
| .SP1 | Microsoft Corporation | Ficheiros Compactados | Microsoft Windows XP With Service Pack 1 Installation Data | Microsoft Windows | Microsoft Corporation |
| .SP4 | Solutions Etcetera | Ficheiros Compactados | SuperCard 4 Player Project | Solutions Etcetera SuperCard | Solutions Etcetera |
| .SPL | Microsoft Corporation | Ficheiros Compactados | Windows Print Spool File | Microsoft Windows | Microsoft Corporation |
| .SPT | Interactive Data Visualization, Inc. | Ficheiros Compactados | SpeedTree Tree Data File | SpeedTree Architect | Interactive Data Visualization, Inc. |
| .SQX | Sven Ritter | Ficheiros Compactados | SQX Archive | SQX archiver | Sven Ritter |
| .SSY | Unknown Developer | Ficheiros Compactados | ScreenShare Compressed Data | ScreenShare | Unknown Developer |
| .SXB | Infor | Ficheiros Compactados | SalesLogix VB Form/Script Transfer | Saleslogix | Infor |
| .SY_ | Microsoft Corporation | Ficheiros Compactados | Compressed SYS File | Microsoft Expand | Microsoft Corporation |
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