| .EARTHTIME | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .EATF | Apple | Ficheiros de Dados | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .EBC | SourceForge | Ficheiros de Desenvolvedor | MediaBASIC Compiled Project | Unknown Software | Unknown Developer |
| .EBV | ASH WARE | Ficheiros de Dados | Ash Ware Enhanced Behavior Data | Unknown Software | Unknown Developer |
| .EBX | IBM | Ficheiros de Desenvolvedor | Rational Rose 98 Compiled Script | Unknown Software | Unknown Developer |
| .EC | Informix Corporation | Ficheiros de Desenvolvedor | Informix ESQL/C Source | Unknown Software | Unknown Developer |
| .ECA | Unknown Developer | Ficheiros CAD | ElectroCAD File | Unknown Software | Unknown Developer |
| .ECC | Carsten Gnörlich | Ficheiros de Dados | Dvdisaster Error Correction File | Unknown Software | Unknown Developer |
| .ECELP4800 | Nuera Communications | Ficheiros de Configurações | Nuera ECELP Speech Codec Family | Unknown Software | Unknown Developer |
| .ECELP7470 | Nuera Communications | Ficheiros de Áudio | Nuera Audio File | Unknown Software | Unknown Developer |
| .ECELP9600 | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .ECLIPSEPRO | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .ECMA | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .ECW2002PUZ | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .ECW2002WOR | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .EFC | Unknown Developer | Ficheiros de Dados | EFCoins File | Unknown Software | Unknown Developer |
| .EFW | Corel | Ficheiros Compactados | Renamed Zip Or Executable File | funzip | Unknown Developer |
| .EGT | EagleGet | Uncommon Files | EagleGet Temporary File | Unknown Software | Unknown Developer |
| .EIF | Envex Solutions | Ficheiros de Dados | Envex Import Format File | Unknown Software | Unknown Developer |
| .EIZ | EIAS3D | Ficheiros Gráficos | Electric Image File Format | Unknown Software | Unknown Developer |
| .EKA | Borland | Ficheiros de Dados | Eureka Internal Data File | Unknown Software | Unknown Developer |
| .EKY | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .ELF | Nintendo | Ficheiros Executáveis | Nintendo Wii Game File | objdump | Unknown Developer |
| .ELN | Blackboard Collaborate | Ficheiros de Dados | Blackboard Collaborate Note Document | Unknown Software | Unknown Developer |
| .EMJSX | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .EMK | Elex Media | Ficheiros de Cópia de Segurança | EMK Compress Archive | Unknown Software | Unknown Developer |
| .EMQ | Unknown Developer | Uncommon Files | Uncommon File Extension | Unknown Software | Unknown Developer |
| .EMQZ | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .EMR | Unknown Developer | Uncommon Files | Emrite Data File | Emrite | Unknown Developer |
| .EMS | Intergraph Corporation | Ficheiros de Dados | Intergraph Engineering Modelling System File | Unknown Software | Unknown Developer |
| .EMZJ | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .EOS | Unknown Developer | Uncommon Files | Uncommon File Extension | Unknown Software | Unknown Developer |
| .EP3 | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .EPV | Unknown Developer | Uncommon Files | Uncommon File Extension | Unknown Software | Unknown Developer |
| .EQN | Altium | Ficheiros CAD | GAL Equation File | eqn2jed | Unknown Developer |
| .ER2 | Apple | Ficheiros de Dados | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .ERIC | Apple | Ficheiros de Dados | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .EST2015 | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .ETA | Google | Ficheiros GIS | Google Earth Placemark File | Unknown Software | Unknown Developer |
| .ETM | Etreppid Technologies, LLC | Ficheiros de Áudio | eTreppid Audio File | Unknown Software | Unknown Developer |
| .ETW | Enter Tech | Ficheiros de Áudio | Enter Tech Recorded Audio | Unknown Software | Unknown Developer |
| .EUC | Unknown Developer | Ficheiros de Texto | Extended Unix Code File | EUC-JP decoder | Unknown Developer |
| .EV6 | Unknown Developer | Uncommon Files | EV8 Virtual Reality Applications File | Unknown Software | Unknown Developer |
| .EVA | Unknown Developer | Ficheiros Gráficos | Viz Modeler 3D Scene Archive File | Unknown Software | Unknown Developer |
| .EWZ | Qivx, Inc. | Ficheiros Compactados | EdgeWize Compressed Encoded Data File | Unknown Software | Unknown Developer |
| .EX2 | Unknown Developer | Ficheiros de Dados | Exodus II File | Exodus II | Unknown Developer |
| .EXEMPLE | Apple | Ficheiros de Dados | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .EXPLOSION | Apple | Ficheiros de Dados | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .EYA | ESRI China (Beijing) | Ficheiros Gráficos | eYaViewer Graphics File | Unknown Software | Unknown Developer |
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