| .S11 | Interplay Entertainment | Ficheiros de Jogo | Descent 2 Game Data | Unsealer | Oracle Corporation |
| .S1A | Oracle Corporation | Ficheiros Codificados | Sealed Acrobat Document | Unsealer | Oracle Corporation |
| .S1E | SealedMedia | Ficheiros Codificados | Sealed Excel Worksheet File | Unsealer | Oracle Corporation |
| .S1M | Yamaha Corporation | Ficheiros de Áudio | Yamaha EX5 Waveform Data | Unsealer | Oracle Corporation |
| .S1N | SealedMedia | Ficheiros Encriptados | Sealed PNG Graphic File | Unsealer | Oracle Corporation |
| .SAL | Oracle Corporation | Ficheiros de Desenvolvedor | SQL Application Language Source Code | MySQL | Oracle Corporation |
| .SDA | Oracle Corporation | Ficheiros de Imagem de Vetor | StarOffice Drawing | StarOffice | Oracle Corporation |
| .SDD | Programming Sunrise | Ficheiros de Dados | Smart Diary Suite Data File | StarOffice | Oracle Corporation |
| .SDG | Golden Software LLC | Ficheiros CAD | Strater Project File | StarOffice | Oracle Corporation |
| .SDM | Oracle Corporation | Ficheiros de Texto | StarOffice Mail Message | StarOffice | Oracle Corporation |
| .SDOC | Samsung Electronics | Ficheiros de Dados | Samsung Memo File | Oracle IRM Desktop | Oracle Corporation |
| .SDP | Oracle Corporation | Ficheiros de Dados | StarOffice Presentation File | StarOffice | Oracle Corporation |
| .SDS | Oracle Corporation | Ficheiros de Dados | OpenOffice.org Chart | StarOffice | Oracle Corporation |
| .SECURITY | Oracle Corporation | Ficheiros de Dados | Javasoft Jre 1.3 Lib Security Data | Java | Oracle Corporation |
| .SEM | Alpha Software | Ficheiros de Desenvolvedor | Alpha Five Set Data Dictionary Memo File | Unsealer | Oracle Corporation |
| .SEML | Oracle Corporation | Uncommon Files | Sealed EML Document | Oracle IRM Desktop | Oracle Corporation |
| .SFS | Open Source | Ficheiros Compactados | Squashfs File Archive | StarOffice | Oracle Corporation |
| .SGV | Oracle Corporation | Ficheiros Gráficos | StarOffice StarDraw 2.0 Picture Image File | StarOffice | Oracle Corporation |
| .SIZ | Oracle Corporation | Ficheiros de Configurações | Oracle 7 Configuration File | Oracle Database | Oracle Corporation |
| .SJP | Oracle Corporation | Ficheiros Codificados | Sealed JPG File | Oracle IRM Desktop | Oracle Corporation |
| .SJPG | Oracle Corporation | Ficheiros Codificados | Sealed JPG File | Oracle IRM Desktop | Oracle Corporation |
| .SMH | Oracle Corporation | Ficheiros de Texto | Sealed MHT Document | Unsealer | Oracle Corporation |
| .SPD | AutoDesSys, Inc. | Uncommon Files | Form-Z Suspended Render Data | Unsealer | Oracle Corporation |
| .SPDF | Oracle Corporation | Ficheiros Codificados | Sealed PDF File | Oracle IRM Desktop | Oracle Corporation |
| .SPN | Corel | Ficheiros de Configurações | Corel WordPerfect Distribution Definition | Unsealer | Oracle Corporation |
| .SPP | Serif | Ficheiros de Imagem Raster | Serif PhotoPlus Picture File | Unsealer | Oracle Corporation |
| .SPS | IBM | Ficheiros de Dados | SPSS Program File | Oracle Database | Oracle Corporation |
| .SQL | Various Developers | Ficheiros de Base de Dados | Structured Query Language Data File | MySQL | Oracle Corporation |
| .SQR | Oracle Corporation | Ficheiros de Dados | SQL Program File | MySQL | Oracle Corporation |
| .SR | Sun Microsystems | Ficheiros de Imagem Raster | Sun Raster Image File | Sun Operating System | Oracle Corporation |
| .SSW | Sony Mobile Communications | Uncommon Files | Sony Ericsson Firmware File | Unsealer | Oracle Corporation |
| .STD | Oracle Corporation | Ficheiros de Imagem de Vetor | Apache OpenOffice Drawing Template | StarOffice | Oracle Corporation |
| .STI | Oracle Corporation | Ficheiros de Dados | StarOffice Presentation Template | StarOffice | Oracle Corporation |
| .SUN | Sun Microsystems | Ficheiros de Imagem Raster | Sun Raster Graphic File | Sun Operating System | Oracle Corporation |
| .SXD | ESRI | Ficheiros GIS | ArcScene Document | StarOffice | Oracle Corporation |
| .SXG | Oracle Corporation | Ficheiros de Texto | Apache OpenOffice Master Document | StarOffice | Oracle Corporation |
| .SXL | SealedMedia | Ficheiros Codificados | Sealed Excel Worksheet File | Unsealer | Oracle Corporation |
| .SXLS | Oracle Corporation | Ficheiros de Folha de Cálculo | Sealed Excel Spreadsheet | Oracle IRM Desktop | Oracle Corporation |
| .SXML | Oracle Corporation | Ficheiros Codificados | Sealed XML File | Oracle IRM Desktop | Oracle Corporation |
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