| .EAP | Sparx Systems | Ficheiros de Dados | Enterprise Architect Project | Adobe Photoshop CC | Adobe Systems Incorporated |
| .EBX | IBM | Ficheiros de Desenvolvedor | Rational Rose 98 Compiled Script | Adobe Creative Suite | Adobe Systems Incorporated |
| .EDB | Microsoft Corporation | Ficheiros de Base de Dados | Exchange Information Store Database | Adobe Photoshop | Adobe Systems Incorporated |
| .EDD | Adobe Systems Incorporated | Ficheiros de Dados | Adobe FrameMaker Element Definition Document File | Adobe FrameMaker | Adobe Systems Incorporated |
| .EDL | Avid Technology | Ficheiros de Vídeo | Edit Decision List File | Adobe Premiere Pro CC | Adobe Systems Incorporated |
| .EDM | Adobe Systems Incorporated | Ficheiros de Desenvolvedor | Adobe Extension Data Markup Language File | Adobe Dreamweaver | Adobe Systems Incorporated |
| .EDML | Adobe Systems Incorporated | Ficheiros de Desenvolvedor | Adobe Extension Data Markup Language File | Adobe Dreamweaver | Adobe Systems Incorporated |
| .EDN | Xilinx, Inc. | Ficheiros CAD | EDIF Implementation Netlist File | Adobe Acrobat DC | Adobe Systems Incorporated |
| .EDT | Adobe Systems Incorporated | Ficheiros de eBook | Adobe eBook Download Settings | Adobe Digital Editions | Adobe Systems Incorporated |
| .EMF | Microsoft Corporation | Ficheiros de Imagem de Vetor | Enhanced Windows Metafile | Adobe Illustrator CC | Adobe Systems Incorporated |
| .EMZ | Microsoft Corporation | Ficheiros de Imagem de Vetor | Windows Compressed Enhanced Metafile | Adobe Illustrator CC | Adobe Systems Incorporated |
| .ENV | Adobe Systems Incorporated | Ficheiros de Dados | Adobe Dictionary Data File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .EPR | Adobe Systems Incorporated | Ficheiros de Configurações | Photoshop AME Preset File | Adobe Photoshop CC | Adobe Systems Incorporated |
| .EPS | Adobe Systems Incorporated | Ficheiros de Imagem de Vetor | Encapsulated PostScript File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .EPSF | Adobe Systems Incorporated | Ficheiros de Imagem de Vetor | Encapsulated PostScript Format File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .EPSI | Adobe Systems Incorporated | Ficheiros Gráficos | Adobe Encapsulated PostScript Interchange Format | Adobe Photoshop | Adobe Systems Incorporated |
| .EPT | Adobe Systems Incorporated | Uncommon Files | Adobe Encapsulated PostScript Interchange Format With TIFF Preview | Adobe Acrobat DC | Adobe Systems Incorporated |
| .EPUB | IDPF (International Digital Publishing Forum) | Ficheiros de eBook | Open eBook File | Adobe InDesign | Adobe Systems Incorporated |
| .ETD | Adobe Systems Incorporated | Ficheiros de eBook | Adobe Reader EBX Transfer Data File | Adobe Acrobat DC | Adobe Systems Incorporated |
| .EXP | Unknown Developer | Ficheiros de Desenvolvedor | Symbols Export File | Adobe Acrobat DC | Adobe Systems Incorporated |
| .EXR | Adobe Systems Incorporated | Ficheiros de Imagem Raster | OpenEXR Image | Adobe Photoshop | Adobe Systems Incorporated |
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