| .S01 | Lithops Software | Arquivos de dados | ZipSplitter Part 2 Archive | Lithops Software ZipSplitter | Lithops Software |
| .S03 | Corel Corporation | Arquivos de dados | Corel WordPerfect Distribution File | Corel WordPerfect | Corel |
| .S2 | Motorola | Arquivos de dados | Motorola S-record Format | Unknown Software | Unknown Developer |
| .S2P | Sonnet Software | Arquivos de dados | Sonnet S-device Parameter Data File | Sonnet Suites | Sonnet Software |
| .S2R | Unknown Developer | Arquivos de dados | RegMagik File | RegMagik | Unknown Developer |
| .S31 | TamoSoft | Arquivos de dados | SmartWhois File | SmartWhois | TamoSoft |
| .S4D | RIAM (French National Network for Research and Innovation on Multimedia) | Arquivos de dados | RIAM AVA Motion S4D Data | AVA Motion | RIAM (French National Network for Research and Innovation on Multimedia) |
| .S4MI | Motorola | Arquivos de dados | Motorola Skin Editor Data File | Motorola Skin Editor | Motorola |
| .S4P | Open Source | Arquivos de dados | Touchstone 16 S-parameters Data File | Notepad++ | Don Ho |
| .S4T | i4i, Inc | Arquivos de dados | S4/TEXT And Tagless Editor Data | Unknown Software | Unknown Developer |
| .S7F | Siemens AG | Arquivos de dados | STEP 7 Project | Step 7-Micro/WIN | Siemens AG |
| .S7S | Sony | Arquivos de dados | Sony Ericsson S700i Phone Firmware Data | Sony Ericsson Mobile Phones | Sony Mobile Communications |
| .S8 | SIMUL8 | Arquivos de dados | SIMUL8 Simulation Data | SIMUL8 | SIMUL8 |
| .S85 | sabre airline solutions | Arquivos de dados | SABRE StaffPlan Chart | SABRE staffplan software | sabre airline solutions |
| .SAA | Information Security Corporation (ISC) | Arquivos de dados | SecretAgent Encrypted Archive File | SecretAgent | Information Security Corporation (ISC) |
| .SAD | LucasArts Entertainment Company, LLC | Arquivos de dados | Lucas Arts Sound Data | Dragon UnPACKer | Open Source |
| .SAF | DeLorme | Arquivos de dados | Street Atlas USA Map File | DeLorme Street Atlas USA | DeLorme |
| .SAH | Berkeley Systems | Arquivos de dados | SETI@home Data File | BOINC | University of California, Berkeley |
| .SAL | Oracle Corporation | Arquivos de dados | SQL Application Language Source Code | MySQL | Oracle Corporation |
| .SAM | Microsoft Corporation | Arquivos de dados | LMHOSTS Sample File | Notepad++ | Don Ho |
| .SAMPLE | Unknown Developer | Arquivos de dados | Saved Sample | Unknown Software | Unknown Developer |
| .SAPSSD | SAP | Arquivos de dados | SAP Data | SAP Business All-In-One | SAP |
| .SAR | Commodore International | Arquivos de dados | Saracen Paint Image | XnView MP | XnSoft |
| .SAS7BCAT | SAS Institute Inc. | Arquivos de dados | SAS Version 8 Random Access File Catalog | SAS | SAS Institute Inc. |
| .SAV | Nintendo | Arquivos de dados | Saved Game File | No Cash GBA (No$GBA) | Martin Korth |
| .SAX | Open Source | Arquivos de dados | Sedona Framework XML Application | Sedona Framework | Open Source |
| .SBA | SpeedBalance.nl | Arquivos de dados | SpeedBalance Accounting Data | SpeedBalance | SpeedBalance.nl |
| .SBD | Microsoft Corporation | Arquivos de dados | Office Accounting Company Data File | Microsoft Office Accounting | Microsoft Corporation |
| .SBF | Google | Arquivos de dados | Android System File | Google Android | Google |
| .SBI | Creative Technology Ltd. | Arquivos de dados | Sound Blaster Instrument | Virtual Sound Blaster | Creative Technology Ltd. |
| .SBK | SwishZone | Arquivos de dados | SWiSH Project Backup File | SWiSH Max | SwishZone |
| .SBL | Adobe Systems Incorporated | Arquivos de dados | Shockwave Flash Object | Adobe Flash Player | Adobe Systems Incorporated |
| .SBP | Autodesk, Inc. | Arquivos de dados | Sketchbook Express iCloud Image | SketchBook | Autodesk, Inc. |
| .SBS | Allegorithmic | Arquivos de dados | Substance Package | Substance Designer | Allegorithmic |
| .SBT | URUWORKS | Arquivos de dados | SBT Subtitle File | URUWorks Subtitle Workshop | URUWORKS |
| .SBW | US Treasury | Arquivos de dados | US Treasury Savings Bonds Wizard File | US Treasury Savings Bond Wizard | US Treasury |
| .SBX | Dream Design Entertainment Software | Arquivos de dados | GLBasic Shoebox File | GLBasic | Dream Design Entertainment Software |
| .SC3 | EA Maxis | Arquivos de dados | SimCity 3000 City File | Maxis SimCity 3000 | EA Maxis |
| .SCA | Symantec Corporation | Arquivos de dados | Norton AntiVirus Scan File | Norton Antivirus | Symantec Corporation |
| .SCD | Intuit, Inc. | Arquivos de dados | TurboTax Tax Schedule List | Intuit Quicken | Quicken |
| .SCE | Open Source | Arquivos de dados | Scilab Script | Scilab | Open Source |
| .SCF | Microsoft Corporation | Arquivos de dados | Windows Explorer Command | Microsoft Windows | Microsoft Corporation |
| .SCG | Midori Media | Arquivos de dados | MyPM SCG Definition File | Midori Media myPM SCG Classic | Midori Media |
| .SCH | Autodesk, Inc. | Arquivos de dados | EAGLE Schematics File | Autodesk EAGLE | Autodesk, Inc. |
| .SCI | Open Source | Arquivos de dados | Scilab Script | Scilab | Open Source |
| .SCL | Avid Technology | Arquivos de dados | Sibelius Chord Diagram Library | Avid Sibelius | Avid Technology |
| .SCM | Gimpel Software | Arquivos de dados | GIMP Script-Fu Script | GIMP | The GIMP Development Team |
| .SCN | Microsoft Corporation | Arquivos de dados | Age Of Mythology Scenario File | Microsoft Age of Empires | Ensemble Studios |
| .SCO | MR Software | Arquivos de dados | OMSI Scenery Object Configuration File | OMSI | MR Software |
| .SCORES | Unknown Developer | Arquivos de dados | Unknown Apple II File. (found On Golden Orchard Apple II CD Rom) | Atom | GitHub, Inc. |
| .SCS_TOR | Accelrys Software Inc. | Arquivos de dados | Insight II Torsion File | Insight II | Accelrys Software Inc. |
| .SCX | RIX SoftWorks, Inc. | Arquivos de dados | ColoRIX Bitmap Graphic File | XnView MP | XnSoft |
| .SCZ | OpenLimit SignCubes AG | Arquivos de dados | OpenLimit SignCubes Zip Container File | OpenLimit CC Sign | OpenLimit SignCubes AG |
| .SDA | Oracle Corporation | Arquivos de dados | StarOffice Drawing | Apache OpenOffice | Apache Software Foundation |
| .SDC | Stardock Corporation | Arquivos de dados | Stardock Central Download Archive | Stardock Central | Stardock Corporation |
| .SDD | Programming Sunrise | Arquivos de dados | Smart Diary Suite Data File | Smart Diary Suite | Programming Sunrise |
| .SDE | Groundlevel Software, Inc. | Arquivos de dados | Drumbeat Exported Data File | DrumBeat | Groundlevel Software, Inc. |
| .SDF | Microsoft Corporation | Arquivos de dados | SQL Server Compact Database File | Microsoft Visual Studio | Microsoft Corporation |
| .SDI | Intuit, Inc. | Arquivos de dados | QuickBooks Data File | Intuit QuickBooks Pro | Intuit, Inc. |
| .SDK | Autodesk, Inc. | Arquivos de dados | AutoSketch Drawing | AutoSketch | Autodesk, Inc. |
| .SDL | Microsoft Corporation | Arquivos de dados | Service Description Language File | Safari | Apple |
| .SDM | Oracle Corporation | Arquivos de dados | StarOffice Mail Message | StarOffice | Oracle Corporation |
| .SDN | Robert K. Jung | Arquivos de dados | Shareware Distributors Network File | ARJ Software JAR | Robert K. Jung |
| .SDOC | Samsung Electronics | Arquivos de dados | Samsung Memo File | Samsung Kies | Samsung Electronics |
| .SDP | Oracle Corporation | Arquivos de dados | StarOffice Presentation File | Apache OpenOffice | Apache Software Foundation |
| .SDS | Oracle Corporation | Arquivos de dados | OpenOffice.org Chart | Apache OpenOffice | Apache Software Foundation |
| .SDT | Intuit, Inc. | Arquivos de dados | QuickBooks Data File | Intuit QuickBooks Pro | Intuit, Inc. |
| .SDU | Edwards Systems Technology, Inc. | Arquivos de dados | Edwards Systems Technology File | Unknown Software | Unknown Developer |
| .SDV | Pinnacle Systems Inc. | Arquivos de dados | Studio DV Project File | Pinnacle Studio | Corel |
| .SDX | Kivuto | Arquivos de dados | Kivuto Secure Download Manager File | Kivuto Secure Download Manager | Kivuto |
| .SDY | StarMoney | Arquivos de dados | StarMoney Financial Data | StarMoney | StarMoney |
| .SEARCHCONNECTOR-MS | Microsoft Corporation | Arquivos de dados | Microsoft Windows Search Connector Description File | Microsoft Windows | Microsoft Corporation |
| .SECURITY | Oracle Corporation | Arquivos de dados | Javasoft Jre 1.3 Lib Security Data | Java | Oracle Corporation |
| .SEED | Open Source | Arquivos de dados | Linux Preseed File | Ubuntu | Open Source |
| .SEG | SEG (The Society of Exploration Geophysicists) | Arquivos de dados | SEG-2 Data File | Unknown Software | Unknown Developer |
| .SEL | Mincom | Arquivos de dados | LinkOne Selection List File | Mincom LinkOne WebView | Mincom |
| .SEM | Alpha Software | Arquivos de dados | Alpha Five Set Data Dictionary Memo File | Alpha Anywhere - Alpha Software | Alpha Software |
| .SEN | Neyer Software LLC | Arquivos de dados | SenTest Data File | Neyer Software SenTest | Neyer Software LLC |
| .SEO | Link Engine Management Ltd. | Arquivos de dados | PC Link File | PC Link | Link Engine Management Ltd. |
| .SEP | PictView software | Arquivos de dados | Separated Image File | PictView | PictView software |
| .SEQ | PG Music Inc | Arquivos de dados | PowerTracks Pro Audio Project File | PowerTracks Pro Audio | PG Music Inc |
| .SER | Thermo Fisher Scientific Inc. | Arquivos de dados | GeneMapper Project File | GeneMapper | Thermo Fisher Scientific Inc. |
| .SERIAL | Apple | Arquivos de dados | Golden Orchard Apple II CD Rom File | Apple OS X | Apple |
| .SERVER | Interscape | Arquivos de dados | Bonobo Activation API File | GNOME Desktop | Interscape |
| .SETUP | Crytek | Arquivos de dados | CryENGINE Character Setup File | Crytek CryENGINE SDK | Crytek |
| .SEV | Open Source | Arquivos de dados | SevenUp Picture | ZX-Paintbrush | Open Source |
| .SF | Institut de Recherche et de Coordination Acoustique/Musique (IRCAM) | Arquivos de dados | IRCAM Sound File | Awave Studio | FMJ-Software |
| .SF3 | Statpoint Technologies, Inc. | Arquivos de dados | STATGRAPHICS Data File | STATGRAPHICS | Statpoint Technologies, Inc. |
| .SFA | Sony | Arquivos de dados | Sony Sound Forge File | Sound Forge Pro | Magix Software GmbH |
| .SFF | Elecbyte | Arquivos de dados | M.U.G.E.N. Sprite File | Elecbyte M.U.G.E.N | Elecbyte |
| .SFM | Samsung Electronics | Arquivos de dados | S Memo Data Cache | S Memo | Samsung Electronics |
| .SFS | Open Source | Arquivos de dados | Squashfs File Archive | 7-Zip | Igor Pavlov |
| .SG | Unknown Developer | Arquivos de dados | SG-1000 Game ROM File | Kega Fusion | Steve Snake |
| .SGB | Relic Entertainment | Arquivos de dados | Dawn Of War Map File | Relic Entertainment Dawn of War | Relic Entertainment |
| .SGCPO | Stenograph | Arquivos de dados | Case CATalyst File | Case CATalyst | Stenograph |
| .SGML | Corel | Arquivos de dados | Standard Generalized Markup Language File | Corel WordPerfect X8 | Corel |
| .SGN | Signet Bureau | Arquivos de dados | Signet Bureau DRM File | SGN Viewer | Signet Bureau |
| .SGNGL | Stenograph | Arquivos de dados | Case CATalyst File | Case CATalyst | Stenograph |
| .SGO | Volkswagen | Arquivos de dados | ECU Update | Engine Control Unit (ECU) | Volkswagen |
| .SGR | Electronic Arts | Arquivos de dados | SimCity 4 Graphics Rules File | Electronic Arts SimCity 4 | Electronic Arts |
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