| .MUL | OriginLab | Arquivos de jogos | Ultima Online Multi File | MULTool | Interscape |
| .NBU | Nokia | Arquivos de cópia | Nokia Phone Backup Copy File | NbuExplorer | Interscape |
| .NFB | Nokia | Arquivos de cópia | Nokia Phone Backup File | NbuExplorer | Interscape |
| .NFC | Nokia | Arquivos de cópia | Nokia Phone Backup Copy File | NbuExplorer | Interscape |
| .NH | Interscape | Arquivos de jogos | NetHack Game Configuration File | NetHack | Interscape |
| .NMEA | Interscape | Arquivos de dados | NMEA GPS Data File | NMEA to KML Converter | Interscape |
| .NOKIA | Nokia | Arquivos de áudio | Nokia Proprietary Ringtone | NbuExplorer | Interscape |
| .NVL | Interscape | Arquivos de dados | UniChem Results File | Oxford Molecular UniChem | Interscape |
| .OWL | Interscape | Arquivos de desenvolvedor | OWL Source Code File | OWL | Interscape |
| .PDV | Kitware, Inc. | Arquivos Gráficos | Visualization Toolkit Graphic File | Visualization ToolKit | Interscape |
| .PIZ | Winrar | Arquivos comprimidos | Zipped File | ZDevs ZArchiver | Interscape |
| .PMF | ESRI | Arquivos GIS | ESRI Published Map File | Lande PMF Player | Interscape |
| .PPM | The GIMP Development Team | Arquivos de imagem Raster | Portable Pixmap Image File | BB5 FLS Editor | Interscape |
| .PS2 | Datel | Arquivos de jogos | Sharkport Saved Game File | PS2 Save Builder | Interscape |
| .PSV | Sony | Arquivos de jogos | PlayStation 2 Save File | PS2 Save Builder | Interscape |
| .PUP | Sony | Arquivos comprimidos | PlayStation 3 Update File | PS3 PUP Extractor | Interscape |
| .PVR | Imagination Technologies | Arquivos de imagem Raster | POWERVR Texture File | Wintal International PVRX2 Player | Interscape |
| .QF | Nokia | Arquivos de configuração | Nokia (Ovi) Maps Version Data | Qompose | Interscape |
| .QT | Apple | Arquivos de vídeo | Apple QuickTime Movie | J2 Interactive MX Player | Interscape |
| .QTM | Apple | Arquivos de vídeo | Apple QuickTime Movie | J2 Interactive MX Player | Interscape |
| .R00 | Rocky Sand Studio | Arquivos comprimidos | WinRAR Compressed Archive | ZDevs ZArchiver | Interscape |
| .RAR | Rocky Sand Studio | Arquivos comprimidos | WinRAR Compressed Archive | ZDevs ZArchiver | Interscape |
| .RDB | EMC | Arquivos de cópia | Retrospect Backup Set | QuickView | Interscape |
| .REP | Rockstar Games | Arquivos de jogos | Grand Theft Auto Replay File | X-Plane | Interscape |
| .RIS | Research Systems, Inc | Arquivos de Texto | Research Information Systems Citation File | Wandora | Interscape |
| .RPD | RIB Software | Arquivos de banco de dados | RIB Project Database File | Roleplay Designer | Interscape |
| .RS | Pierre-Emmanuel Gougelet | Arquivos 3D | Sun Raster Bitmap Image | rustc | Interscape |
| .RSK | Interscape | Arquivos de dados | RiskMan Risk Project File | RiskMan | Interscape |
| .RVF | Interscape | Arquivos de Texto | RichView Format File | TRichView | Interscape |
| .S7Z | Igor Pavlov | Arquivos comprimidos | 7-Zip Compressed File | ZDevs ZArchiver | Interscape |
| .SAV | Nintendo | Arquivos de jogos | Saved Game File | Dualis | Interscape |
| .SBC | Microsoft Corporation | Arquivos miscelâneas | Office Accounting Company Shortcut File | SBC File Archiver | Interscape |
| .SC2 | EA Maxis | Arquivos de jogos | SimCity 2000 City File | Sample Cell II | Interscape |
| .SCAR | Interscape | Arquivos executáveis | SCAR Script File | SCAR | Interscape |
| .SCW | Genie | Arquivos miscelâneas | Score Writer Document | Screenwriter's Print Script Viewer | Interscape |
| .SERVER | Interscape | Arquivos de dados | Bonobo Activation API File | GNOME Desktop | Interscape |
| .SF | Institut de Recherche et de Coordination Acoustique/Musique (IRCAM) | Arquivos de áudio | IRCAM Sound File | RMCProfile | Interscape |
| .SFW | Seattle Lab | Arquivos de imagem Raster | Seattle FilmWorks Image | American Greetings SFW & PWP File Converter | Interscape |
| .SG3 | SourceForge | Arquivos de banco de dados | ChessDB Game File | ChessDB | Interscape |
| .SGA | Relic Entertainment | Arquivos de jogos | Relic Entertainment Game Archive | Mod Studio 2 | Interscape |
| .SHX | Autodesk, Inc. | Arquivos CAD | AutoCAD Compiled Shape File | RSD Lite | Interscape |
| .SI3 | Interscape | Arquivos de dados | ChessDB Index File | ChessDB | Interscape |
| .SMF | Oracle Corporation | Arquivos de Texto | StarMath Formula File | Appspeed SkinMagic Toolkit | Interscape |
| .SN3 | Samsung Electronics | Arquivos de cópia | Samsung Kies 2 Backup | ChessDB | Interscape |
| .SNL | Interscape | Arquivos de dados | Egrid32 Form Snippet | EGrid Form Designer | Interscape |
| .SOU | LucasArts Entertainment Company, LLC | Arquivos de jogos | Lucas Arts Sound Data | ScummVM | Interscape |
| .SPF | StorageCraft | Arquivos de cópia | ShadowProtect Full Backup File | SlingPlayer | Interscape |
| .SPM | Corel | Arquivos de dados | Corel WordPerfect Data | StoneTracker | Interscape |
| .SPS | IBM | Arquivos de dados | SPSS Program File | StoneTracker | Interscape |
| .SRO | Unknown Developer | Arquivos de dados | MADCOW Multi-Site ATIS Data Collection Working Group Data | MADCOW (Multi-Site ATIS Data Collection Working Group) | Interscape |
| .SRT | SourceForge | Arquivos de vídeo | SubRip Subtitle File | Aegisub | Interscape |
| .SSA | Open Source | Arquivos de Texto | Sub Station Alpha Subtitle File | J2 Interactive MX Player | Interscape |
| .SSO | Interscape | Arquivos de banco de dados | ChessDB Search Options Data | ChessDB | Interscape |
| .STM | Microsoft Corporation | Arquivos de dados | Exchange Streaming Media File | The Powder Toy | Interscape |
| .STR | dBase, LLC | Arquivos de dados | dBASE Structure List Object File | X-Plane | Interscape |
| .STY | Jørgen Sørensen / Jososoft | Arquivos de áudio | Yamaha/Korg Keyboard Style | GNIStyle | Interscape |
| .SUB | URUWORKS | Arquivos de Texto | Subtitle File | J2 Interactive MX Player | Interscape |
| .SUC | Interscape | Arquivos de dados | Hello Engines! 2.1 Data | Hello Engines | Interscape |
| .SUD | Aivosto Oy | Arquivos de desenvolvedor | Super Project Analyzer Data File | WISCO Word Power | Interscape |
| .SV7 | Nintendo | Arquivos de jogos | Saved Game File | Dualis | Interscape |
| .SVG | Nintendo | Arquivos de jogos | Saved Game File | Dualis | Interscape |
| .SYN | Image-Line | Arquivos de áudio | SimSynth Document | Excessive Speed | Interscape |
| .TEC | SIL International | Arquivos miscelâneas | TECkit Compiled Mapping File | TECO | Interscape |
| .TEX | Open Source | Arquivos de Texto | LaTeX Source Document | Skim | Interscape |
| .TGZ | Various Developers | Arquivos comprimidos | Gzipped Tar File | ZDevs ZArchiver | Interscape |
| .THEME | Microsoft Corporation | Arquivos de sistema | Microsoft Plus! Desktop Theme | GNOME Desktop | Interscape |
| .TKL | Interscape | Arquivos de dados | Takeoff Live PDF Working Data | Takeoff Live | Interscape |
| .TOC | Sony | Arquivos de áudio | Sony PlayStation Portable (PSP) Audio File | Exact Audio Copy for PSP Edition | Interscape |
| .TPX | DeLorme | Arquivos GIS | DeLorme Topo Project File | Topo North America | Interscape |
| .TRA | Interscape | Arquivos de dados | WinTrack Railroad Track Text File | WinTrack | Interscape |
| .TRP | VSO Software | Arquivos de vídeo | MPEG-2 HD Video Transport Stream | EggPaint | Interscape |
| .TRS | Interscape | Arquivos de dados | WinTrack Railroad Track Text File | WinTrack | Interscape |
| .TRX | Microsoft Corporation | Arquivos de desenvolvedor | Visual Studio Test Results File | CyberCash WebAuthorize | Interscape |
| .TTT | Interscape | Arquivos de dados | TestTrack Pro Database File | TestTrack Pro | Interscape |
| .U3I | Interscape | Arquivos de Texto | U3 Application Information File | U3 Launcher | Interscape |
| .UAE | Interscape | Arquivos de desenvolvedor | WinUAE Configuration Data | WinUAE | Interscape |
| .UMD | Ubisoft | Arquivos de jogos | Splinter Cell Blacklist Game Data File | JUMD | Interscape |
| .UPS | Open Source | Arquivos de jogos | UPS Patch File | Tsukuyomi | Interscape |
| .VCA | Interscape | Arquivos de configuração | VAKCER Project Tracker Add-in | VAKCER Project Tracker | Interscape |
| .VD | Interscape | Arquivos de dados | Visual Designer Project | PowerDev | Interscape |
| .VIV | Electronic Arts | Arquivos de jogos | Need For Speed Car Data File | Vivaldi Studio | Interscape |
| .VLP | Interscape | Arquivos Web | LiveSite Project | Valadeo LiveSite | Interscape |
| .VMF | Valve | Arquivos de jogos | Valve Map File | Internet Wave Player | Interscape |
| .VOS | Interscape | Arquivos de áudio | Virtual Orchestra Studio Song Database File | Virtual Orchestra studio | Interscape |
| .VOX | Ken Silverman | Arquivos 3D | Voxlap Voxel Model File | MagicaVoxel | Interscape |
| .VPA | Halsoft.com, Inc | Arquivos miscelâneas | VPchat Chat Gestures File | Excite Chat Alpha | Interscape |
| .VPF | Interscape | Arquivos GIS | Vector Product Format | H2OMAP Water | Interscape |
| .VPG | Interscape | Arquivos de complementos | VAKCER Project Tracker DLL Plug-in | VAKCER Project Tracker | Interscape |
| .VQA | Westwood Studios | Arquivos de jogos | Command And Conquer Game Video Files | Command and Conquer | Interscape |
| .VTI | Kitware, Inc. | Arquivos de dados | Visualization Toolkit Image Data | Visualization ToolKit | Interscape |
| .VTK | Kitware, Inc. | Arquivos Gráficos | Visualization Toolkit Legacy Data | Visualization ToolKit | Interscape |
| .VTP | Kitware, Inc. | Arquivos Gráficos | Visualization Toolkit Polygonal Data | Visualization ToolKit | Interscape |
| .VTX | Richard Bannister | Arquivos de áudio | VTX Chiptune File | Ay Emul | Interscape |
| .WBC | Threefold Photos, Inc. | Arquivos de imagem Raster | Webshots Collection File | WinBatch | Interscape |
| .WBM | Jamie Cameron | Arquivos de complementos | Webmin Module | WinBatch | Interscape |
| .WBT | Nabi Studios | Arquivos de jogos | Toribash Help File | WinBatch | Interscape |
| .WCL | Interscape | Arquivos de dados | WellCAD Log File | WellCAD | Interscape |
| .WDF | Workshare | Arquivos de dados | Workshare Compare DeltaFile | WinGenea | Interscape |
| .WGT | Interscape | Arquivos de dados | IMPS Data File | CSPro | Interscape |
| .WL | Interscape | Arquivos de dados | WISCO Word Power Word Lists And Definitions Data | WISCO Word Power | Interscape |
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