| .EARTHTIME | Unknown Developer | Nietypowe Pliki | Unknown File Type | Unknown Software | Unknown Developer |
| .EATF | Apple | Pliki z danymi | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .EBC | SourceForge | Pliki wydawcy | MediaBASIC Compiled Project | Unknown Software | Unknown Developer |
| .EBV | ASH WARE | Pliki z danymi | Ash Ware Enhanced Behavior Data | Unknown Software | Unknown Developer |
| .EBX | IBM | Pliki wydawcy | Rational Rose 98 Compiled Script | Unknown Software | Unknown Developer |
| .EC | Informix Corporation | Pliki wydawcy | Informix ESQL/C Source | Unknown Software | Unknown Developer |
| .ECA | Unknown Developer | Pliki CAD | ElectroCAD File | Unknown Software | Unknown Developer |
| .ECC | Carsten Gnörlich | Pliki z danymi | Dvdisaster Error Correction File | Unknown Software | Unknown Developer |
| .ECELP4800 | Nuera Communications | Pliki konfiguracyjne | Nuera ECELP Speech Codec Family | Unknown Software | Unknown Developer |
| .ECELP7470 | Nuera Communications | Pliki audio | Nuera Audio File | Unknown Software | Unknown Developer |
| .ECELP9600 | Unknown Developer | Nietypowe Pliki | Unknown File Type | Unknown Software | Unknown Developer |
| .ECLIPSEPRO | Unknown Developer | Nietypowe Pliki | Unknown File Type | Unknown Software | Unknown Developer |
| .ECMA | Unknown Developer | Nietypowe Pliki | Unknown File Type | Unknown Software | Unknown Developer |
| .ECW2002PUZ | Unknown Developer | Nietypowe Pliki | Unknown File Type | Unknown Software | Unknown Developer |
| .ECW2002WOR | Unknown Developer | Nietypowe Pliki | Unknown File Type | Unknown Software | Unknown Developer |
| .EFC | Unknown Developer | Pliki z danymi | EFCoins File | Unknown Software | Unknown Developer |
| .EFW | Corel | Pliki skompresowane | Renamed Zip Or Executable File | funzip | Unknown Developer |
| .EGT | EagleGet | Nietypowe Pliki | EagleGet Temporary File | Unknown Software | Unknown Developer |
| .EIF | Envex Solutions | Pliki z danymi | Envex Import Format File | Unknown Software | Unknown Developer |
| .EIZ | EIAS3D | Pliki graficzny | Electric Image File Format | Unknown Software | Unknown Developer |
| .EKA | Borland | Pliki z danymi | Eureka Internal Data File | Unknown Software | Unknown Developer |
| .EKY | Unknown Developer | Nietypowe Pliki | Unknown File Type | Unknown Software | Unknown Developer |
| .ELF | Nintendo | Pliki wykonywalne | Nintendo Wii Game File | objdump | Unknown Developer |
| .ELN | Blackboard Collaborate | Pliki z danymi | Blackboard Collaborate Note Document | Unknown Software | Unknown Developer |
| .EMJSX | Unknown Developer | Nietypowe Pliki | Unknown File Type | Unknown Software | Unknown Developer |
| .EMK | Elex Media | Pliki kopii zapasowej | EMK Compress Archive | Unknown Software | Unknown Developer |
| .EMQ | Unknown Developer | Nietypowe Pliki | Uncommon File Extension | Unknown Software | Unknown Developer |
| .EMQZ | Unknown Developer | Nietypowe Pliki | Unknown File Type | Unknown Software | Unknown Developer |
| .EMR | Unknown Developer | Nietypowe Pliki | Emrite Data File | Emrite | Unknown Developer |
| .EMS | Intergraph Corporation | Pliki z danymi | Intergraph Engineering Modelling System File | Unknown Software | Unknown Developer |
| .EMZJ | Unknown Developer | Nietypowe Pliki | Unknown File Type | Unknown Software | Unknown Developer |
| .EOS | Unknown Developer | Nietypowe Pliki | Uncommon File Extension | Unknown Software | Unknown Developer |
| .EP3 | Unknown Developer | Nietypowe Pliki | Unknown File Type | Unknown Software | Unknown Developer |
| .EPV | Unknown Developer | Nietypowe Pliki | Uncommon File Extension | Unknown Software | Unknown Developer |
| .EQN | Altium | Pliki CAD | GAL Equation File | eqn2jed | Unknown Developer |
| .ER2 | Apple | Pliki z danymi | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .ERIC | Apple | Pliki z danymi | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .EST2015 | Unknown Developer | Nietypowe Pliki | Unknown File Type | Unknown Software | Unknown Developer |
| .ETA | Google | Pliki GIS | Google Earth Placemark File | Unknown Software | Unknown Developer |
| .ETM | Etreppid Technologies, LLC | Pliki audio | eTreppid Audio File | Unknown Software | Unknown Developer |
| .ETW | Enter Tech | Pliki audio | Enter Tech Recorded Audio | Unknown Software | Unknown Developer |
| .EUC | Unknown Developer | Pliki tekstowe | Extended Unix Code File | EUC-JP decoder | Unknown Developer |
| .EV6 | Unknown Developer | Nietypowe Pliki | EV8 Virtual Reality Applications File | Unknown Software | Unknown Developer |
| .EVA | Unknown Developer | Pliki graficzny | Viz Modeler 3D Scene Archive File | Unknown Software | Unknown Developer |
| .EWZ | Qivx, Inc. | Pliki skompresowane | EdgeWize Compressed Encoded Data File | Unknown Software | Unknown Developer |
| .EX2 | Unknown Developer | Pliki z danymi | Exodus II File | Exodus II | Unknown Developer |
| .EXEMPLE | Apple | Pliki z danymi | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .EXPLOSION | Apple | Pliki z danymi | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .EYA | ESRI China (Beijing) | Pliki graficzny | eYaViewer Graphics File | Unknown Software | Unknown Developer |
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