| .DAR | Open Source | Instellingsbestanden | DAR Disk Archive File | DAR (Disk Archive) | Open Source |
| .DB | Dwayne Richard Hipp | Instellingsbestanden | Mobile Device Database File | SQLite | Dwayne Richard Hipp |
| .DBB | GSC Game World | Instellingsbestanden | S.T.A.L.K.E.R. Game File | S.T.A.L.K.E.R | GSC Game World |
| .DBG | Microsoft Corporation | Instellingsbestanden | Visual FoxPro Debugger Configuration File | Microsoft Visual FoxPro | Microsoft Corporation |
| .DBH | Freescale | Instellingsbestanden | CodeWarrior Debug Preferences | CodeWarrior | NXP |
| .DCC | Nokia | Instellingsbestanden | Nokia Dynamic Camera Configuration | Symbian OS | Nokia |
| .DCF | Sony Mobile Communications | Instellingsbestanden | DRM Content Format File | DRM Packager | Sony Mobile Communications |
| .DCL | Autodesk, Inc. | Instellingsbestanden | AutoCAD Dialog Definition File | Autodesk AutoCAD Ecscad | Autodesk, Inc. |
| .DCN | Autodesk, Inc. | Instellingsbestanden | Autodesk Depth Slope Definition | Autodesk AutoCAD Civil 3D | Autodesk, Inc. |
| .DCP | Embarcadero Technologies | Instellingsbestanden | Delphi Compiled Package | Delphi (IDE) | Embarcadero Technologies |
| .DDF | Microsoft Corporation | Instellingsbestanden | Diamond Directive File | Microsoft Notepad | Microsoft Corporation |
| .DDR | Microcosm Ltd. | Instellingsbestanden | DDRemote Parameter Data | Dinkey Pro/FD | Microcosm Ltd. |
| .DFM | Open Source | Instellingsbestanden | Pascal File | Notepad++ | Don Ho |
| .DFN | Embarcadero Technologies | Instellingsbestanden | Delphi Definition Data | RAD Studio | Embarcadero Technologies |
| .DFR | SmartWare Corporation | Instellingsbestanden | SmartWare Report Definition File | SmartWare | SmartWare Corporation |
| .DFS | Open Source | Instellingsbestanden | BrainSuite Surface File | BrainSuite | Open Source |
| .DFT | Breaktru Software | Instellingsbestanden | eJuice Me Up Default Settings File | eJuice Me Up | Breaktru Software |
| .DICPROOF | Microsoft Corporation | Instellingsbestanden | Microsoft Dictionary Proofing File | Microsoft Excel | Microsoft Corporation |
| .DIRECTORY | KDE | Instellingsbestanden | KDE Folder View Properties File | KDE (K Desktop Environment) | KDE |
| .DKS | Symantec Corporation | Instellingsbestanden | DataKeeper Configuration File | DataKeeper | Symantec Corporation |
| .DML | Sybase, Inc | Instellingsbestanden | DynaScript File | Internet Explorer | Microsoft Corporation |
| .DMV | Adobe Systems Incorporated | Instellingsbestanden | Adobe Acrobat Catalog Data | Adobe Acrobat DC | Adobe Systems Incorporated |
| .DNP | Apple | Instellingsbestanden | DRM Digital Rights Management Data | Apple QuickTime Player | Apple |
| .DOK | Nenad Hrg | Instellingsbestanden | DesktopOK Icons Layout File | DesktopOK | Nenad Hrg |
| .DOP | DxO Labs | Instellingsbestanden | DxO Optics Pro Correction Settings File | DxO OpticsPro | DxO Labs |
| .DOWNLOADHOST | Microsoft Corporation | Instellingsbestanden | MSN Explorer Download View | MSN Explorer | Microsoft Corporation |
| .DPI | Adlib Tracker II | Instellingsbestanden | Adlib Express Document Processing Information Settings | Adlib Express | Adlib Tracker II |
| .DPS | DivX, LLC. | Instellingsbestanden | DivX Player 2 Skin File | DivX | DivX, LLC. |
| .DPV | Siemens PLM Software | Instellingsbestanden | Siemens NX Drafting Standard Filed | Siemens PLM NX | Siemens PLM Software |
| .DSC | Kingsoft | Instellingsbestanden | Kingsoft Design Science Equation File | Kingsoft Office | Kingsoft |
| .DSD | Autodesk, Inc. | Instellingsbestanden | AutoCAD Drawing Set Description File | Autodesk AutoCAD | Autodesk, Inc. |
| .DSF | DAZ 3D | Instellingsbestanden | DAZ Studio Asset File | DAZ Studio | DAZ 3D |
| .DSH | SnoopSoft | Instellingsbestanden | Dashboard PDA Wallpaper File | DashBoard | SnoopSoft |
| .DSL | ABBYY | Instellingsbestanden | Lingvo Dictionary Data File | ABBYY Lingvo Dictionary | ABBYY |
| .DST | Autodesk, Inc. | Instellingsbestanden | AutoCAD Sheet Set File | Autodesk AutoCAD Ecscad | Autodesk, Inc. |
| .DSW | Microsoft Corporation | Instellingsbestanden | Microsoft Visual Studio Workspace | Microsoft Visual Studio | Microsoft Corporation |
| .DSX | DAZ 3D | Instellingsbestanden | DAZ Studio XML File | DAZ Studio | DAZ 3D |
| .DS_STORE | Apple | Instellingsbestanden | Mac OS X Folder Settings File | Mac OS X Finder | Apple |
| .DTB | DataCAD LLC | Instellingsbestanden | DataCAD Custom Toolbar File | DataCAD | DataCAD LLC |
| .DTD | Syncro Soft | Instellingsbestanden | Document Type Definition File | Microsoft Notepad | Microsoft Corporation |
| .DUCK | Open Source | Instellingsbestanden | Cyberduck Bookmark | Cyberduck | Open Source |
| .DUN | Trendy Entertainment | Instellingsbestanden | Dungeon Defenders Saved Game File | Trendy Entertainment Dungeon Defenders | Trendy Entertainment |
| .DUP | Microsoft Corporation | Instellingsbestanden | Microsoft Windows DUA Polling Reconfiguration Data | Microsoft Windows | Microsoft Corporation |
| .DUPX | Logix Business Integration | Instellingsbestanden | DuupeCheck Project File | DuupeCheck | Logix Business Integration |
| .DVP | Autodesk, Inc. | Instellingsbestanden | AutoCAD Device Parameter File Format | Autodesk AutoCAD | Autodesk, Inc. |
| .DZS | SpeedBit | Instellingsbestanden | Download Accelerator Skin | Download Accelerator Plus | SpeedBit |
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