| .S11 | Interplay Entertainment | Spelbestanden | Descent 2 Game Data | Interplay Descent 2 | Interplay Entertainment |
| .S16 | Sports Interactive | Spelbestanden | Football Manager Game Data | Football Manager 2016 | Sports Interactive |
| .S2 | Motorola | Spelbestanden | Motorola S-record Format | Unknown Software | Unknown Developer |
| .S2R | Unknown Developer | Spelbestanden | RegMagik File | RegMagik | Unknown Developer |
| .S3R | 49Games | Spelbestanden | RTL Ski Jumping Replay File | RTL Ski Jumping | 49Games |
| .S4M | Irrational Games | Spelbestanden | SWAT 4 Map File | SWAT 4 | Irrational Games |
| .SA1 | VBA Team | Spelbestanden | Game Boy Emulator Save File | VisualBoyAdvance | VBA Team |
| .SABS | Activision | Spelbestanden | Call Of Duty: Black Ops Sound Archive | Call of Duty: Black Ops | Activision |
| .SACRED2SAVE | Ascaron Entertainment | Spelbestanden | Sacred 2 Saved Game | Sacred 2: Fallen Angel | Ascaron Entertainment |
| .SAD | LucasArts Entertainment Company, LLC | Spelbestanden | Lucas Arts Sound Data | Dragon UnPACKer | Open Source |
| .SAK | Running With Scissors | Spelbestanden | Postal Game Archive | Postal | Running With Scissors |
| .SAN | LucasArts Entertainment Company, LLC | Spelbestanden | Smush Animation File | Star Wars: Rebel Assault | LucasArts Entertainment Company, LLC |
| .SAV | Nintendo | Spelbestanden | Saved Game File | No Cash GBA (No$GBA) | Martin Korth |
| .SAZ | Microsoft Corporation | Spelbestanden | Fiddler Session Archive ZIP Data | Fiddler | Microsoft Corporation |
| .SBF | Google | Spelbestanden | Android System File | Google Android | Google |
| .SBM | Keen Software House | Spelbestanden | Space Engineers Mod File | Space Engineers | Keen Software House |
| .SC2 | EA Maxis | Spelbestanden | SimCity 2000 City File | Maxis SimCity 2000 | EA Maxis |
| .SC3 | EA Maxis | Spelbestanden | SimCity 3000 City File | Maxis SimCity 3000 | EA Maxis |
| .SC4 | Chris Sawyer | Spelbestanden | RollerCoaster Tycoon Scenario File | RollerCoaster Tycoon 3 | Frontier Developments plc |
| .SC4DESC | Electronic Arts | Spelbestanden | SimCity 4 Description File | Electronic Arts SimCity 4 | Electronic Arts |
| .SC4LOT | Electronic Arts | Spelbestanden | SimCity 4 Lot File | Electronic Arts SimCity 4 | Electronic Arts |
| .SC6 | Chris Sawyer | Spelbestanden | RollerCoaster Tycoon 2 Scenario File | RollerCoaster Tycoon 2: Triple Thrill Pack | Chris Sawyer |
| .SCENE | Fandom | Spelbestanden | Antibody Level File | Hidden Temple Studios Antibody | Fandom |
| .SCF | Microsoft Corporation | Spelbestanden | Windows Explorer Command | Microsoft Windows | Microsoft Corporation |
| .SCM | Gimpel Software | Spelbestanden | GIMP Script-Fu Script | GIMP | The GIMP Development Team |
| .SCN | Microsoft Corporation | Spelbestanden | Age Of Mythology Scenario File | Microsoft Age of Empires | Ensemble Studios |
| .SCO | MR Software | Spelbestanden | OMSI Scenery Object Configuration File | OMSI | MR Software |
| .SCS | Electronic Arts | Spelbestanden | SimCity Societies Saved Game File | SimCity Societies | Tilted Mill Entertainment |
| .SCX | RIX SoftWorks, Inc. | Spelbestanden | ColoRIX Bitmap Graphic File | XnView MP | XnSoft |
| .SCZ | OpenLimit SignCubes AG | Spelbestanden | OpenLimit SignCubes Zip Container File | OpenLimit CC Sign | OpenLimit SignCubes AG |
| .SD7 | Unknown Developer | Spelbestanden | Spring RTS Engine Data File | Spring | Open Source |
| .SDF | Microsoft Corporation | Spelbestanden | SQL Server Compact Database File | Microsoft Visual Studio | Microsoft Corporation |
| .SDP | Oracle Corporation | Spelbestanden | StarOffice Presentation File | Apache OpenOffice | Apache Software Foundation |
| .SDT | Intuit, Inc. | Spelbestanden | QuickBooks Data File | Intuit QuickBooks Pro | Intuit, Inc. |
| .SEP | PictView software | Spelbestanden | Separated Image File | PictView | PictView software |
| .SFB | Sony | Spelbestanden | PlayStation 3 Disc Data File | Microsoft Notepad | Microsoft Corporation |
| .SFC | Unknown Developer | Spelbestanden | Super Nintendo ROM | Snes9x | Snes9x Team |
| .SFF | Elecbyte | Spelbestanden | M.U.G.E.N. Sprite File | Elecbyte M.U.G.E.N | Elecbyte |
| .SFL | Magix Software GmbH | Spelbestanden | Sound Forge Pro Sound Data File | MAGIX Vegas | Magix Software GmbH |
| .SFO | Interscape | Spelbestanden | PSP Game Parameters File | PBP Unpacker | Unknown Developer |
| .SFS | Open Source | Spelbestanden | Squashfs File Archive | 7-Zip | Igor Pavlov |
| .SG | Unknown Developer | Spelbestanden | SG-1000 Game ROM File | Kega Fusion | Steve Snake |
| .SGA | Relic Entertainment | Spelbestanden | Relic Entertainment Game Archive | Relic Entertainment Dawn of War | Relic Entertainment |
| .SGB | Relic Entertainment | Spelbestanden | Dawn Of War Map File | Relic Entertainment Dawn of War | Relic Entertainment |
| .SGI | Silicon Graphics, Inc. | Spelbestanden | Silicon Graphics Image File | Canvas X | ACD Systems |
| .SGM | VBA Team | Spelbestanden | VisualBoyAdvance Saved Game | VisualBoyAdvance | VBA Team |
| .SGR | Electronic Arts | Spelbestanden | SimCity 4 Graphics Rules File | Electronic Arts SimCity 4 | Electronic Arts |
| .SHADER | id Software | Spelbestanden | Quake 3 Arena Id Tech 3 Game Engine Shader File | Quake 3 Arena | id Software |
| .SID | Valve | Spelbestanden | Steam Game Data Backup File | Steam | Valve |
| .SII | SCS Software | Spelbestanden | 18 Wheels Of Steel: Haulin' Truck Definition File | SCS 18 Wheels of Steel: Haulin' | SCS Software |
| .SIMS2PACK | Electronic Arts | Spelbestanden | Downloaded Sims 2 Package File | Electronic Arts The Sims 2 | Electronic Arts |
| .SIN | Big Huge Games | Spelbestanden | Rise Of Nations Campaign Media File | Rise Of Nations | Big Huge Games |
| .SKD | Rockstar Games | Spelbestanden | Max Payne Skin Data File | chUmbaLum sOft MilkShape 3D | chUmbaLum sOft |
| .SKN | Avant Force | Spelbestanden | Avant Browser Skin File | Avant Browser | Avant Force |
| .SLF | Symantec Corporation | Spelbestanden | Symantec License File | Symantec Ghost Solution Suite | Symantec Corporation |
| .SLH | BioWare | Spelbestanden | Baldur's Gate II Game Data | Baldur's Gate | BioWare |
| .SLI | MR Software | Spelbestanden | OMSI Spline Configuration File | OMSI 2 | MR Software |
| .SLM | Morrison Software | Spelbestanden | Gallery Lock Hidden Media | Gallery Lock Pro | Morrison Software |
| .SLP | Magix Software GmbH | Spelbestanden | SpectraLayers Pro Project | SpectraLayers Pro | Magix Software GmbH |
| .SM | Open Source | Spelbestanden | StepMania Song File | StepMania | Open Source |
| .SMC | Snes9x Team | Spelbestanden | Super Nintendo Game ROM | Snes9x | Snes9x Team |
| .SMD | Valve | Spelbestanden | Valve Studiomdl Data File | Microsoft Notepad | Microsoft Corporation |
| .SMK | RAD Game Tools | Spelbestanden | Smacker Compressed Movie File | RAD Video Tools | RAD Game Tools |
| .SMO | Gravitysensation.com | Spelbestanden | Sumotori Dreams Arena File | Sumotori Dreams | Gravitysensation.com |
| .SMS | Sega | Spelbestanden | Sega Master System ROM | Kega Fusion | Steve Snake |
| .SMV | Smith Micro Software | Spelbestanden | VideoLink Mail Video File | Smith Micro Videolink Pro | Smith Micro Software |
| .SMZIP | Open Source | Spelbestanden | StepMania Package | StepMania | Open Source |
| .SNA | Tom Ehlert Software | Spelbestanden | Drive Snapshot Primary Backup File | Tom Ehlert Drive Snapshot | Tom Ehlert Software |
| .SND | Open Source | Spelbestanden | Sound File | Microsoft Windows Media Player | Microsoft Corporation |
| .SNI | Interplay Entertainment | Spelbestanden | MDK Game Archive | MDK | Interplay Entertainment |
| .SNT | Microsoft Corporation | Spelbestanden | Microsoft Windows Sticky Notes File | Sticky Notes | Microsoft Corporation |
| .SOD | id Software | Spelbestanden | Spear Of Destiny Data File | Spear of Destiny | id Software |
| .SOK | Open Source | Spelbestanden | Sokoban++ Level File | Sokoban | Open Source |
| .SOT | Human Entertainment | Spelbestanden | Adventure SOS Adventure Game Walkthrough Source File | SOS (1993 video game) | Human Entertainment |
| .SOU | LucasArts Entertainment Company, LLC | Spelbestanden | Lucas Arts Sound Data | Dragon UnPACKer | Open Source |
| .SOUNDS | id Software | Spelbestanden | Quake 3 Engine Sound Definition File | Microsoft Notepad | Microsoft Corporation |
| .SOW | Interplay Entertainment | Spelbestanden | Descent ARJ Archive | Smith Micro StuffIt Deluxe | Smith Micro Software |
| .SP2 | Amusement Vision (SEGA) | Spelbestanden | Super Ball 2 Level File | Super Ball 2 | Unknown Developer |
| .SP4 | Solutions Etcetera | Spelbestanden | SuperCard 4 Player Project | Solutions Etcetera SuperCard | Solutions Etcetera |
| .SPA | Yu Higuchi | Spelbestanden | MikuMikuDance Sphere Mapping File | MikuMikuDance | Yu Higuchi |
| .SPB | Samsung Electronics | Spelbestanden | Samsung Kies Phonebook File | Samsung Kies | Samsung Electronics |
| .SPC | Various Developers | Spelbestanden | Software Publisher Certificate File | OpenSSL | Open Source |
| .SPK | Atari Corporation | Spelbestanden | Deer Hunter Map File | Deer Hunter | Sunstorm Interactive, Inc. |
| .SPL | Microsoft Corporation | Spelbestanden | Windows Print Spool File | Microsoft Windows | Microsoft Corporation |
| .SPO | Electronic Arts | Spelbestanden | Spore Saved Game | Electronic Arts Spore | Electronic Arts |
| .SPRITE | MIT Media Lab | Spelbestanden | Scratch Sprite File | MIT Scratch | MIT Media Lab |
| .SPS | IBM | Spelbestanden | SPSS Program File | IBM SPSS | IBM |
| .SPT | Interactive Data Visualization, Inc. | Spelbestanden | SpeedTree Tree Data File | SpeedTree Architect | Interactive Data Visualization, Inc. |
| .SQF | Bohemia Interactive | Spelbestanden | ArmA Script File | ArmA: Armed Assault | Bohemia Interactive |
| .SQM | Microsoft Corporation | Spelbestanden | Service Quality Monitoring File | Microsoft Windows | Microsoft Corporation |
| .SQS | Bohemia Interactive | Spelbestanden | Operation FlashPoint Script | Operation FlashPoint | Bohemia Interactive |
| .SRG | Ketron | Spelbestanden | Ketron Single Registration File | Ketron Software | Ketron |
| .SRM | Nintendo | Spelbestanden | Super Nintendo ROM Save File | Snes9x | Snes9x Team |
| .SS | Open Source | Spelbestanden | SilverStripe Source Code File | SilverStripe | Open Source |
| .SSA | Open Source | Spelbestanden | Sub Station Alpha Subtitle File | VirtualDub | Open Source |
| .SSC | Microsoft Corporation | Spelbestanden | SourceSafe Status File | Microsoft Visual Studio | Microsoft Corporation |
| .SSFREC | McLeodGaming | Spelbestanden | Super Smash Flash Recording Data | Super Smash Flash | McLeodGaming |
| .SSL | Bethesda Softworks | Spelbestanden | Fallout Script | Fallout Script Editor | Jargo |
| .SSS | Stardock Corporation | Spelbestanden | WindowBlinds Substyle File | WindowBlinds | Stardock Corporation |
| .SST | Microsoft Corporation | Spelbestanden | Serialized Certificate Store File | Certificate Manager Tool | Microsoft Corporation |
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