| .SOU | LucasArts Entertainment Company, LLC | Audiobestanden | Lucas Arts Sound Data | Dragon UnPACKer | Open Source |
| .SPH | National Institute of Standards and Technology (NIST) | Audiobestanden | NIST SPHERE Audio File | SoX | Open Source |
| .SPM | Corel | Audiobestanden | Corel WordPerfect Data | Corel WordPerfect | Corel |
| .SPS | IBM | Audiobestanden | SPSS Program File | IBM SPSS | IBM |
| .SPU | Atari Corporation | Audiobestanden | Spectrum 512 Image | Lemkesoft GraphicConverter | Lemkesoft |
| .SPX | Xiph.Org | Audiobestanden | Ogg Vorbis Speex File | Microsoft Windows Media Player | Microsoft Corporation |
| .SRI | Nuance | Audiobestanden | Dragon NaturallySpeaking Audio Data File | Dragon NaturallySpeaking | Nuance |
| .SS3 | Unknown Developer | Audiobestanden | Singer Song Writer Audio File | Unknown Software | Unknown Developer |
| .SSM | RealNetworks | Audiobestanden | Standard Streaming Metafile | RealPlayer | Realtime Technologies |
| .STI | Oracle Corporation | Audiobestanden | StarOffice Presentation Template | Apache OpenOffice | Apache Software Foundation |
| .STM | Microsoft Corporation | Audiobestanden | Exchange Streaming Media File | Microsoft Exchange Server | Microsoft Corporation |
| .STW | Oracle Corporation | Audiobestanden | StarOffice Document Template | Apache OpenOffice | Apache Software Foundation |
| .STX | Unknown Developer | Audiobestanden | Scream Tracker Music Interface Kit File | CocoModX | Open Source |
| .STY | Jørgen Sørensen / Jososoft | Audiobestanden | Yamaha/Korg Keyboard Style | Style Fixer | Jørgen Sørensen / Jososoft |
| .STZ | Future Crew | Audiobestanden | Screamtracker 2 Module | Scream Tracker 3 | Future Crew |
| .SUN | Sun Microsystems | Audiobestanden | Sun Raster Graphic File | GIMP | The GIMP Development Team |
| .SVD | Polytec | Audiobestanden | Scanning Vibrometer Data File | Polytec PSV Software | Polytec |
| .SVQ | Roland Corporation | Audiobestanden | Roland Sequencer File | Awave Studio | FMJ-Software |
| .SVX | The Survex Project | Audiobestanden | Survex Cavern Data File | Microsoft Notepad | Microsoft Corporation |
| .SW | Waveform Software | Audiobestanden | Signed Word Audio File | Waveform SoX Wrap | Waveform Software |
| .SWA | Adobe Systems Incorporated | Audiobestanden | Shockwave Audio | Adobe Director | Adobe Systems Incorporated |
| .SXT | FMJ-Software | Audiobestanden | Propellerheads Reason 2 NN-XT Sound Data | FMJ-Software Awave Audio | FMJ-Software |
| .SYN | Image-Line | Audiobestanden | SimSynth Document | FL Studio 12 | Image-Line |
| .SYW | Yamaha Corporation | Audiobestanden | Yamaha SY99/SY85 Audio File | Awave Studio | FMJ-Software |
| .SYX | Cakewalk, Inc. | Audiobestanden | MIDI System Exclusive Message | Cakewalk SONAR | Cakewalk, Inc. |
| .TAK | K & K Associates | Audiobestanden | TAK 2000 Thermal Model File | TAK 2000 | K & K Associates |
| .TD0 | Sydex | Audiobestanden | Teledisk Archive | Teledisk | Sydex |
| .TG | Julian Gabriel Casadesus and Others | Audiobestanden | TuxGuitar Document | TuxGuitar | Julian Gabriel Casadesus and Others |
| .THX | Cloanto Corporation | Audiobestanden | Amiga THX Tracker Music File | CocoModX | Open Source |
| .TKS | Native Instruments | Audiobestanden | Traktor Pro MIDI Map File | Traktor | Native Instruments |
| .TOC | Sony | Audiobestanden | Sony PlayStation Portable (PSP) Audio File | Exact Audio Copy for PSP Edition | Interscape |
| .TSH | CENiX, Inc. | Audiobestanden | Cenix Audio | Unknown Software | Unknown Developer |
| .TSI | Native Instruments | Audiobestanden | Traktor Settings File | Traktor | Native Instruments |
| .TSP | Inmatrix Media Solutions | Audiobestanden | Digital TV DVR Recording | Zoom Player | Inmatrix Media Solutions |
| .TTA | True Audio | Audiobestanden | True Audio File | VLC Media Player | VideoLAN |
| .TTX | Simple DirectMedia Layer (SDL) | Audiobestanden | Trados TagEditor File | SDL Trados | SDL Trados |
| .TUN | High Voltage Software | Audiobestanden | LEGO Racers Audio File | Audacity | Open Source |
| .TVI | Terminal Reality | Audiobestanden | Terminal Velocity Game Animation File | Terminal Velocity | Terminal Reality |
| .TVN | Yamaha Corporation | Audiobestanden | Yamaha Tyros Audio | Awave Studio | FMJ-Software |
| .TXW | Yamaha Corporation | Audiobestanden | Yamaha TX16W Audio File | TX16WConverter | Unknown Developer |
| .U | Epic Games | Audiobestanden | Unreal Tournament Class Package | Dragon UnPACKer | Open Source |
| .U8 | Nintendo | Audiobestanden | Mario Kart Wii Archive File | Wiimms SZS Toolset | Nintendo |
| .UAX | Epic Games | Audiobestanden | Unreal Audio Package | Dragon UnPACKer | Open Source |
| .UB | Waveform Software | Audiobestanden | Unsigned Byte Audio File | Apple QuickTime Player | Apple |
| .UDW | FMJ-Software | Audiobestanden | Raw Unsigned DoubleWord (32-bit) Data | Awave Studio | FMJ-Software |
| .ULT | Radionomy | Audiobestanden | UltraTracker Module | CocoModX | Open Source |
| .ULW | NCH Software | Audiobestanden | U-Law Audio File | NCH Switch | NCH Software |
| .UNI | Open Source | Audiobestanden | MikMod UniMOD Module | CocoModX | Open Source |
| .USF | EVGA Corporation | Audiobestanden | EVGA Precision X Skin File | EVGA PrecisionX | EVGA Corporation |
| .USR | FileMaker Inc. | Audiobestanden | FileMaker Pro Database File | FileMaker Pro | FileMaker Inc. |
| .UST | UTAU Team | Audiobestanden | UTAU Sequence Text File | Vocal Synthesizer Tool UTAU | UTAU Team |
| .UVD | Yamaha Corporation | Audiobestanden | Yamaha Tyros4 Audio Data | Tyros4 | Yamaha Corporation |
| .UVN | Yamaha Corporation | Audiobestanden | Yamaha Tyros Audio | Awave Studio | FMJ-Software |
| .UW | Apple | Audiobestanden | Unsigned Word Audio File | Apple QuickTime Player | Apple |
| .UWF | Marc Andrй Schallehn | Audiobestanden | UltraTracker Wave File | CocoModX | Open Source |
| .V2M | Farbrausch | Audiobestanden | V2 Synthesizer Audio File | Nullsoft Winamp | Nullsoft |
| .V8 | FMJ-Software | Audiobestanden | Covox 8-bit Audio File | Awave Studio | FMJ-Software |
| .VAB | Sony | Audiobestanden | Sony Playstation/PS2 Audio Bank | Awave Studio | FMJ-Software |
| .VAG | Sony | Audiobestanden | Sony Playstation/PS2 Compressed Sound File | Nullsoft Winamp | Nullsoft |
| .VAL | Interscape | Audiobestanden | Valodas Dictionary File | Valodas | Valodas |
| .VAP | Dialogic | Audiobestanden | Dialogic Indexed Voice Audio File | Syntellect VoiceXML Studio | Syntellect |
| .VB | Microsoft Corporation | Audiobestanden | Visual Basic Project Item File | Microsoft Notepad | Microsoft Corporation |
| .VCE | Avanset | Audiobestanden | Visual CertExam Suite Exam File | Visual CertExam Suite | Avanset |
| .VGM | Richard Bannister | Audiobestanden | Video Game Music File | Nullsoft Winamp | Nullsoft |
| .VGZ | Various Developers | Audiobestanden | Video Game Music Compressed File | Nullsoft Winamp | Nullsoft |
| .VIF | AccuSoft Corporation | Audiobestanden | Khoros Visualization Bitmap Image | VisiQuest (Khoros) | AccuSoft Corporation |
| .VIP | JKI | Audiobestanden | Virtual Instrument Package | JKI VIPM | JKI |
| .VIV | Electronic Arts | Audiobestanden | Need For Speed Car Data File | Need For Speed | Electronic Arts |
| .VI_ | Unknown Developer | Audiobestanden | Samplitude Compressed File | Audio Waveprg | Unknown Developer |
| .VLC | VideoLAN | Audiobestanden | VLC Playlist | VLC Media Player | VideoLAN |
| .VM | Apache HTTP Project Management Committee | Audiobestanden | Velocity Template | Apache Velocity | Open Source |
| .VMD | Open Source | Audiobestanden | Covox Raw Sample | Virtual Sound Blaster | Creative Technology Ltd. |
| .VMF | Valve | Audiobestanden | Valve Map File | Valve Hammer Editor | Valve |
| .VMO | Siemens AG | Audiobestanden | Siemens Voice Memo File | Siemens Mobile Phones | Siemens AG |
| .VOC | Creative Technology Ltd. | Audiobestanden | Creative Labs Audio File | Nullsoft Winamp | Nullsoft |
| .VOS | Interscape | Audiobestanden | Virtual Orchestra Studio Song Database File | Virtual Orchestra studio | Interscape |
| .VOX | Ken Silverman | Audiobestanden | Voxlap Voxel Model File | MagicaVoxel | Interscape |
| .VPL | Unknown Developer | Audiobestanden | Karaoke Player Playlist | vanBasco's Karaoke Player | Open Source |
| .VPM | Garmin | Audiobestanden | Garmin Voice File | TTSVoiceEditor | Open Source |
| .VQE | Yamaha Corporation | Audiobestanden | Yamaha Sound-VQ Locator File | Unknown Software | Unknown Developer |
| .VQF | Yamaha Corporation | Audiobestanden | TwinVQ Audio File | Nullsoft Winamp | Nullsoft |
| .VQL | Yamaha Corporation | Audiobestanden | Yamaha Sound-VQ Locator File | Unknown Software | Unknown Developer |
| .VRF | Flagship Industries, Inc. | Audiobestanden | Ventrilo Audio Recording | Ventrilo | Flagship Industries, Inc. |
| .VTX | Richard Bannister | Audiobestanden | VTX Chiptune File | Audio Overload | Richard Bannister |
| .VWD | Cubig Group, LLC Trademarks | Audiobestanden | Cubig | Cubig Digital Recorder | Cubig Group, LLC Trademarks |
| .VY4 | Samsung Electronics | Audiobestanden | Samsung Voice Codec | SBC Codec | Samsung Electronics |
| .W64 | Sony | Audiobestanden | Sony Wave64 Audio File | ShedWorx Smart Converter | Shedworx |
| .W7S | Yamaha Corporation | Audiobestanden | Yamaha Synthesizer User Song Data File | Yamaha MO Music Production Synthesizer | Yamaha Corporation |
| .WA | Open Source | Audiobestanden | Windows Addon Archive | Win Toolkit | Open Source |
| .WAPTT | WhatsApp Inc | Audiobestanden | WhatsApp Messenger Voicemail Recording | WhatsApp | WhatsApp Inc |
| .WAV | Microsoft Corporation | Audiobestanden | WAVE Audio File | Microsoft Windows Media Player | Microsoft Corporation |
| .WAX | Microsoft Corporation | Audiobestanden | Windows Media Audio Redirect | Microsoft Windows Media Player | Microsoft Corporation |
| .WEBA | Inmatrix Media Solutions | Audiobestanden | Zoom Player WebM Audio | Zoom Player | Inmatrix Media Solutions |
| .WFB | Turtle Beach Corporation | Audiobestanden | WaveFront Sound Bank | Turtle Beach WaveFront Software | Turtle Beach Corporation |
| .WFD | Turtle Beach Corporation | Audiobestanden | WaveFront Drum Kit File | Turtle Beach WaveFront Software | Turtle Beach Corporation |
| .WFM | Avid Technology | Audiobestanden | Pro Tools Wave Cache File | Avid Pro Tools | Avid Technology |
| .WFP | Turtle Beach Corporation | Audiobestanden | WaveFront Program File | Turtle Beach WaveFront Software | Turtle Beach Corporation |
| .WMA | Microsoft Corporation | Audiobestanden | Windows Media Audio File | Microsoft Windows Media Player | Microsoft Corporation |
| .WOW | Open Source | Audiobestanden | Grave Composer Music Module | OpenMPT | Open Source |
| .WPK | Corel | Audiobestanden | WordPerfect Macro | Corel WordPerfect X8 | Corel |
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