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| Uitbreiding | Bestandstype Ontwikkelaar | Bestandscategorie | Bestandstype Beschrijving | Software | Software-ontwikkelaar |
|---|---|---|---|---|---|
| .U | Epic Games | Spelbestanden | Unreal Tournament Class Package | Dragon UnPACKer | Open Source |
| .UAX | Epic Games | Audiobestanden | Unreal Audio Package | Dragon UnPACKer | Open Source |
| .UB | Waveform Software | Audiobestanden | Unsigned Byte Audio File | SoX | Open Source |
| .UBIFS | Various Developers | Schijfimagebestanden | Linux UBIFS Image | Linux | Open Source |
| .UBJ | The Buzz Media | Gegevensbestanden | Universal Binary JSON File | Ubjson.NET | Open Source |
| .UDF | Open Source | Schijfimagebestanden | Universal Disk Format Image File | PeaZip | Open Source |
| .UKX | Epic Games | Spelbestanden | Unreal Animation Package | Dragon UnPACKer | Open Source |
| .ULT | Radionomy | Audiobestanden | UltraTracker Module | CocoModX | Open Source |
| .UMF | GetMediaHolder.com | Gegevensbestanden | MediaHolder Universal Media Format File | PSPad | Open Source |
| .UMS | Open Source | Gecomprimeerde bestanden | Dragon UnPACKer Version 5 Archive File | Dragon UnPACKer | Open Source |
| .UMX | Epic Games | Spelbestanden | Unreal Music Package | ModPlug Player | Open Source |
| .UNF | Open Source | Spelbestanden | UNIF ROM File | Nestopia | Open Source |
| .UNI | Open Source | Audiobestanden | MikMod UniMOD Module | CocoModX | Open Source |
| .UPD | Various Developers | Tekstbestanden | Program Update Information | Notepad2 | Open Source |
| .UPR | Open Source | Gegevensbestanden | Fractal Parameters File | Apophysis | Open Source |
| .UPS | Open Source | Spelbestanden | UPS Patch File | MultiPatch patching tool | Open Source |
| .UPT | Open Source | Gegevensbestanden | Connectivity Memory Model Update Timing Input Data File | Neural Network Simulation Software | Open Source |
| .UPX | Open Source | Gecomprimeerde bestanden | Ultimate Packer For eXecutables File | PeaZip | Open Source |
| .USR | FileMaker Inc. | Databasebestanden | FileMaker Pro Database File | GPSBabel | Open Source |
| .USX | Epic Games | Spelbestanden | Unreal Static Meshes | Dragon UnPACKer | Open Source |
| .UTX | Epic Games | Spelbestanden | Unreal Texture Package | Dragon UnPACKer | Open Source |
| .UTXT | Open Source | Tekstbestanden | Unicode Text File | Notepad2 | Open Source |
| .UU | Open Source | Versleutelde bestanden | Uuencoded File | Uuencode | Open Source |
| .UUD | Open Source | Versleutelde bestanden | UUDecoded File | UUDeview | Open Source |
| .UUE | Open Source | Versleutelde bestanden | Uuencoded File | Uuencode | Open Source |
| .UWF | Marc Andrй Schallehn | Audiobestanden | UltraTracker Wave File | CocoModX | Open Source |
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