| .SOC | Apache Software Foundation | File di settaggi | OpenOffice.org Configuration File | Apache OpenOffice | Apache Software Foundation |
| .SOL | Adobe Systems Incorporated | File di settaggi | Flash Local Shared Object File | Adobe Flash Player | Adobe Systems Incorporated |
| .SPF | StorageCraft | File di settaggi | ShadowProtect Full Backup File | VMware vCenter Converter | VMware |
| .SPFX | Sorenson Media | File di settaggi | Squeeze Presets File | Squeeze | Sorenson Media |
| .SPJ | IBM | File di settaggi | SPSS Production Job File | IBM SPSS | IBM |
| .SPN | Corel | File di settaggi | Corel WordPerfect Distribution Definition | Corel WordPerfect | Corel |
| .SPS | IBM | File di settaggi | SPSS Program File | IBM SPSS | IBM |
| .SQD | SparkPath Technologies | File di settaggi | Configuration Settings File | SP Debugger for SQR | SparkPath Technologies |
| .SRF | NewTek | File di settaggi | LightWave Surface File | LightWave 3D | NewTek |
| .SRP | Check Point Software Technologies Ltd. | File di settaggi | Checkpoint Exported VPN Client Information File | ZoneAlarm Pro | Check Point Software Technologies Ltd. |
| .SRS | Microsoft Corporation | File di settaggi | Outlook Send/Receive Settings File | Microsoft Outlook | Microsoft Corporation |
| .SRV | FBB Software | File di settaggi | FBB Initialization Settings | FBB Packet-Radio BBS | FBB Software |
| .SSB | Joshua Cannon Butcher | File di settaggi | Simply Safe Backup Archive | Simply Safe Backup | Joshua Cannon Butcher |
| .SSL | Bethesda Softworks | File di settaggi | Fallout Script | Fallout Script Editor | Jargo |
| .SSS | Stardock Corporation | File di settaggi | WindowBlinds Substyle File | WindowBlinds | Stardock Corporation |
| .SSZ | Open Source | File di settaggi | Spider Player Skin File | Spider Player Pro | Open Source |
| .STB | Autodesk, Inc. | File di settaggi | AutoCAD Plot Style Table File | Autodesk AutoCAD | Autodesk, Inc. |
| .STC | Adobe Systems Incorporated | File di settaggi | Contribute Connection Key File | Adobe Contribute 6.5 | Adobe Systems Incorporated |
| .STD | Oracle Corporation | File di settaggi | Apache OpenOffice Drawing Template | Apache OpenOffice | Apache Software Foundation |
| .STE | Adobe Systems Incorporated | File di settaggi | Dreamweaver Site Settings File | Microsoft Notepad | Microsoft Corporation |
| .STF | Microsoft Corporation | File di settaggi | Exchange 2000 Server Temporary File | Microsoft Exchange Server | Microsoft Corporation |
| .STP | Unknown Developer | File di settaggi | STEP 3D CAD File | CATIA | Dassault Systèmes |
| .STT | Microsoft Corporation | File di settaggi | Streets & Trips Map Template | Microsoft AutoRoute | Microsoft Corporation |
| .STY | Jørgen Sørensen / Jososoft | File di settaggi | Yamaha/Korg Keyboard Style | Style Fixer | Jørgen Sørensen / Jososoft |
| .STYLE | Trimble Inc. | File di settaggi | SketchUp Style | SketchUp | Trimble Inc. |
| .SUBLIME-KEYMAP | Sublime HQ Pty Ltd | File di settaggi | Sublime Text Keymap Data | Sublime Text | Sublime HQ Pty Ltd |
| .SUBLIME-PROJECT | Sublime HQ Pty Ltd | File di settaggi | Sublime Text Project | Sublime Text | Sublime HQ Pty Ltd |
| .SUBLIME-SESSION | Sublime HQ Pty Ltd | File di settaggi | Sublime Text Session Data | Sublime Text | Sublime HQ Pty Ltd |
| .SUBLIME-SETTINGS | Sublime HQ Pty Ltd | File di settaggi | Sublime Text Settings | Sublime Text | Sublime HQ Pty Ltd |
| .SUBLIME-SNIPPET | Sublime HQ Pty Ltd | File di settaggi | Sublime Text Snippet | Sublime Text | Sublime HQ Pty Ltd |
| .SUBLIME-SYNTAX | Sublime HQ Pty Ltd | File di settaggi | Sublime Text Syntax Definition Format | Sublime Text | Sublime HQ Pty Ltd |
| .SUBLIME-WORKSPACE | Sublime HQ Pty Ltd | File di settaggi | Sublime Text Workspace Settings | Sublime Text | Sublime HQ Pty Ltd |
| .SUITE | Stardock Corporation | File di settaggi | Stardock WinStyles Suite | ZipZag | Open Source |
| .SVP | SwiftView, Inc. | File di settaggi | SwiftView Command File | SwiftView | SwiftView, Inc. |
| .SVS | Nintendo | File di settaggi | Game Boy Advance Saved State File | Game Boy Advance | Nintendo |
| .SWE | Electronic Arts | File di settaggi | NHL Ice Hockey 2002 Required Data | NHL 2002 | Electronic Arts |
| .SZ | Nullsoft | File di settaggi | Winamp Classic Skin Download | Nullsoft Winamp | Nullsoft |
| .T3D | Epic Games | File di settaggi | Unreal Engine 3D Object File | Unreal Tournament | Epic Games |
| .T3M | Electric Rain | File di settaggi | Swift 3D Material File | Swift 3D | Electric Rain |
| .TAM | TameDOS | File di settaggi | Tame Program Settings | Tame | TameDOS |
| .TB | Tabbery | File di settaggi | Tabbery Tab File | Tabbery | Tabbery |
| .TBB | Microsoft Corporation | File di settaggi | Microsoft Office Toolbar Button | Microsoft Office | Microsoft Corporation |
| .TBE | Pegasys | File di settaggi | TMPGEnc List | TMPGEnc | Pegasys |
| .TBM | Nabi Studios | File di settaggi | Toribash Mod File | Toribash | Nabi Studios |
| .TBR | Adobe Systems Incorporated | File di settaggi | Adobe Photoshop Custom Toolbar Preset | Adobe Photoshop | Adobe Systems Incorporated |
| .TDF | DVD Copy | File di settaggi | Title Definition Format File | DVD X Copy | DVD Copy |
| .TEE | Steema Software | File di settaggi | TeeChart Template | Steema TeeChart | Steema Software |
| .TESTRUNCONFIG | Microsoft Corporation | File di settaggi | Microsoft Visual Studio Test Run Configuration File | Microsoft Visual Studio | Microsoft Corporation |
| .TF | Borland | File di settaggi | Turbo Profiler Configuration | Turbo Profiler | Borland |
| .TFA | Tree Software and Consulting Inc. | File di settaggi | TreeSoft CashFlow Analysis Data File | treeSoft CashFlow Analysis (tree.fa.exe) | treeSoft |
| .TFD | Various Developers | File di settaggi | Tape Format Requirements Document | BAE Systems VITec PC | BAE Systems |
| .TFX | Avid Technology | File di settaggi | Pro Tools Eleven Rack Plugin Preset File | Avid Pro Tools | Avid Technology |
| .TGB | TheGreenBow | File di settaggi | IPSec VPN Client VPN Configuration File | IPSec VPN Client | TheGreenBow |
| .THE | Microsoft Corporation | File di settaggi | Microsoft Plus! Theme File | Microsoft Plus! | Microsoft Corporation |
| .THEME | Microsoft Corporation | File di settaggi | Microsoft Plus! Desktop Theme | Microsoft Windows | Microsoft Corporation |
| .THEMEPACK | Microsoft Corporation | File di settaggi | Microsoft Windows 7 Theme Pack | Microsoft Windows 7 | Microsoft Corporation |
| .THM | Sony | File di settaggi | Sony Ericsson Mobile Phone Theme File | Sony Ericsson Theme Creator | Sony Mobile Communications |
| .THMX | Microsoft Corporation | File di settaggi | Microsoft Office 2007 Theme File | Microsoft Excel | Microsoft Corporation |
| .TIM | Sierra Entertainment | File di settaggi | The Incredible Machine Level | The Incredible Machine | Sierra Entertainment |
| .TLL | LG Electronics | File di settaggi | LG TV Link-Loader File | ChanSort | Open Source |
| .TLO | IBM | File di settaggi | SPSS TableLooks File | IBM SPSS | IBM |
| .TMS | Telemate | File di settaggi | Telemate Script | Telemate | Telemate |
| .TOP | KTH Royal Institute of Technology | File di settaggi | Gromacs Topology File | Gromacs | KTH Royal Institute of Technology |
| .TP | SnapStream Media | File di settaggi | Beyond TV Transport Stream File | CyberLink PowerDVD | CyberLink |
| .TPF | IBM | File di settaggi | SPSS Text Wizard Document | IBM SPSS | IBM |
| .TPL | Unknown Developer | File di settaggi | Document Template | NoteTab | Fookes Software |
| .TPP | Ternion Corporation | File di settaggi | FLAMES GUI Template File | FLAMES | Ternion Corporation |
| .TR | Yadabyte | File di settaggi | TomeRaider 2 eBook File | TomeRaider | Yadabyte |
| .TRW | Borland | File di settaggi | Borland Turbo Debugger For Windows Session-State Settings | Borland Turbo Debugger | Borland |
| .TRX | Microsoft Corporation | File di settaggi | Visual Studio Test Results File | Microsoft Visual Studio | Microsoft Corporation |
| .TSI | Native Instruments | File di settaggi | Traktor Settings File | Traktor | Native Instruments |
| .TSK | Microsoft Corporation | File di settaggi | Pocket PC Skin | Microsoft ActiveSync | Microsoft Corporation |
| .TSM | Beckhoff | File di settaggi | TwinCAT System Manager Configuration File | TwinCat System Manager | Beckhoff |
| .TSP | Inmatrix Media Solutions | File di settaggi | Digital TV DVR Recording | Zoom Player | Inmatrix Media Solutions |
| .TST | Measurement Computing | File di settaggi | TestPoint Test File | Measurement Computing TestPoint | Measurement Computing |
| .TSW | National Instruments | File di settaggi | NI TestStand Workspace | NI TestStand | National Instruments |
| .TSZ | Cerulean Studios | File di settaggi | Trillian Skin File | Cerulean Studios Trillian | Cerulean Studios |
| .TV | Corel | File di settaggi | Corel Paradox Table View Settings | Corel Paradox | Corel |
| .TVC | IMSI/Design, LLC | File di settaggi | Turbo View & Convert Batch Presets File | IMSI TurboCAD Deluxe | Redway3d and others |
| .TVP | NVIDIA | File di settaggi | NVIDIA Graphic Card Update File | NVIDIA Graphics Driver | NVIDIA |
| .TWC | Tripwire, Inc. | File di settaggi | Tripwire Configuration Data File | Tripwire Enterprise | Tripwire, Inc. |
| .TWN | Unknown Developer | File di settaggi | Scanner Settings File | Unknown Software | Unknown Developer |
| .TWS | Helios Software Solutions | File di settaggi | TextPad Workspace | TextPad | Helios Software Solutions |
| .TXM | CFP Software Limited | File di settaggi | CFPwinMan Document File | CFPwinMan | CFP Software Limited |
| .UAP | Siemens AG | File di settaggi | SIMATIC WinCC User Archive Export | TIA Portal | Siemens AG |
| .UBB | Oracle Corporation | File di settaggi | BEA eLink Adapter Configuration Data | BEA eLink Adapter | Oracle Corporation |
| .UCF | Cisco Systems | File di settaggi | WebEx Media File | WebEx Meetings | Cisco Systems |
| .UCI | SysDevSoftware | File di settaggi | UFS Explorer Backup File | SysDevSoftware UFS Explorer | SysDevSoftware |
| .UCX | IBM | File di settaggi | Rational XDE Data | Rational Rose | IBM |
| .UIS | Stardock Corporation | File di settaggi | WindowBlinds User Interface Specification | WindowBlinds | Stardock Corporation |
| .UL | Microsoft Corporation | File di settaggi | Windows Updates Downloader Update List File | Windows Updates Downloader | Microsoft Corporation |
| .ULF | MRF GeoSystems | File di settaggi | Universal List File | MRF Mapping Tool Kit | MRF GeoSystems |
| .ULZ | Microsoft Corporation | File di settaggi | Windows Updates Downloader Update List File | Windows Updates Downloader | Microsoft Corporation |
| .UMB | Microsoft Corporation | File di settaggi | MemMaker Backup Archive | MS-DOS | Microsoft Corporation |
| .UPD | Various Developers | File di settaggi | Program Update Information | Microsoft Notepad | Microsoft Corporation |
| .UPF | Bentley Systems | File di settaggi | MicroStation User Preferences File | MicroStation | Bentley Systems |
| .URF | Matinsoft Inc. | File di settaggi | AppFace Skin File | AppFace User Interface Development Kits | Matinsoft Inc. |
| .URS | ControlDraw Ltd. | File di settaggi | ControlDraw User Requirement Specifier | ControlDraw | ControlDraw Ltd. |
| .USER | Microsoft Corporation | File di settaggi | Visual Studio Project User Options File | Microsoft Notepad | Microsoft Corporation |
| .USF | EVGA Corporation | File di settaggi | EVGA Precision X Skin File | EVGA PrecisionX | EVGA Corporation |
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