| .SAI | SYSTEMAX Software Development | File con immagini raster | PaintTool SAI Image | PaintTool SAI | SYSTEMAX Software Development |
| .SAI2 | SYSTEMAX Software Development | File con immagini raster | Paint Tool SAI Version 2 Drawing | PaintTool SAI | SYSTEMAX Software Development |
| .SAR | Commodore International | File con immagini raster | Saracen Paint Image | XnView MP | XnSoft |
| .SBP | Autodesk, Inc. | File con immagini raster | Sketchbook Express iCloud Image | SketchBook | Autodesk, Inc. |
| .SCANNER | Unknown Developer | File con immagini raster | Scanner Output File | Unknown Software | Unknown Developer |
| .SCG | Midori Media | File con immagini raster | MyPM SCG Definition File | Midori Media myPM SCG Classic | Midori Media |
| .SCN | Microsoft Corporation | File con immagini raster | Age Of Mythology Scenario File | Microsoft Age of Empires | Ensemble Studios |
| .SCP | RIX SoftWorks, Inc. | File con immagini raster | ColoRIX Bitmap Graphic File | XnView MP | XnSoft |
| .SCT | Scitex | File con immagini raster | Scitex Continuous Tone File | Adobe Photoshop | Adobe Systems Incorporated |
| .SCU | RIX SoftWorks, Inc. | File con immagini raster | ColoRIX Bitmap Graphic File | XnView MP | XnSoft |
| .SCX | RIX SoftWorks, Inc. | File con immagini raster | ColoRIX Bitmap Graphic File | XnView MP | XnSoft |
| .SDG | Golden Software LLC | File con immagini raster | Strater Project File | Strater | Golden Software LLC |
| .SDR | Dell Boomi | File con immagini raster | Dell Support File | Unknown Software | Unknown Developer |
| .SEP | PictView software | File con immagini raster | Separated Image File | PictView | PictView software |
| .SFC | Unknown Developer | File con immagini raster | Super Nintendo ROM | Snes9x | Snes9x Team |
| .SFF | Elecbyte | File con immagini raster | M.U.G.E.N. Sprite File | Elecbyte M.U.G.E.N | Elecbyte |
| .SFW | Seattle Lab | File con immagini raster | Seattle FilmWorks Image | Lemkesoft GraphicConverter | Lemkesoft |
| .SGD | Syngene | File con immagini raster | GeneSnap Image File | GeneSnap | Syngene |
| .SGI | Silicon Graphics, Inc. | File con immagini raster | Silicon Graphics Image File | Canvas X | ACD Systems |
| .SHG | Microsoft Corporation | File con immagini raster | Segmented Hyper-Graphic | Microsoft WinHelp | Microsoft Corporation |
| .SID | Valve | File con immagini raster | Steam Game Data Backup File | Steam | Valve |
| .SIG | Unknown Developer | File con immagini raster | Signature File | Microsoft Outlook Express | Microsoft Corporation |
| .SIM | Valve | File con immagini raster | Steam Game Backup Information File | Steam | Valve |
| .SIX | Digital Equipment Corporation | File con immagini raster | DEC LN03+ Sixel Bitmap Image File | Unknown Software | Unknown Developer |
| .SKM | Trimble Inc. | File con immagini raster | SketchUp Materials File | SketchUp | Trimble Inc. |
| .SLD | ESRI (Environmental Systems Research Institute) | File con immagini raster | Styled Layer Descriptor | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SMP | MakeMusic, Inc. | File con immagini raster | SmartMusic Performance File | SmartMusic | MakeMusic, Inc. |
| .SNAP | Erik Kunze | File con immagini raster | ZX Spectrum Emulator Mirage Microdrive Snapshot | XZX-Pro | Erik Kunze |
| .SOB | Apache Software Foundation | File con immagini raster | OpenOffice.org Impress Bimap Styles File | Apache OpenOffice | Apache Software Foundation |
| .SPA | Yu Higuchi | File con immagini raster | MikuMikuDance Sphere Mapping File | MikuMikuDance | Yu Higuchi |
| .SPC | Various Developers | File con immagini raster | Software Publisher Certificate File | OpenSSL | Open Source |
| .SPE | IBM | File con immagini raster | SPSS Extension | IBM SPSS | IBM |
| .SPH | National Institute of Standards and Technology (NIST) | File con immagini raster | NIST SPHERE Audio File | SoX | Open Source |
| .SPIFF | Joint Photographic Experts Group | File con immagini raster | Still Picture Interchange File Format | Unknown Software | Unknown Developer |
| .SPJ | IBM | File con immagini raster | SPSS Production Job File | IBM SPSS | IBM |
| .SPOT | SPOT Image | File con immagini raster | SPOT Satellite Image | SPOT Images | SPOT Image |
| .SPP | Serif | File con immagini raster | Serif PhotoPlus Picture File | PhotoPlus | Serif |
| .SPR | Valve | File con immagini raster | Half-Life Sprite File | Half-Life | Valve |
| .SPRITE | MIT Media Lab | File con immagini raster | Scratch Sprite File | MIT Scratch | MIT Media Lab |
| .SPS | IBM | File con immagini raster | SPSS Program File | IBM SPSS | IBM |
| .SPU | Atari Corporation | File con immagini raster | Spectrum 512 Image | Lemkesoft GraphicConverter | Lemkesoft |
| .SR | Sun Microsystems | File con immagini raster | Sun Raster Image File | GIMP | The GIMP Development Team |
| .SRS | Microsoft Corporation | File con immagini raster | Outlook Send/Receive Settings File | Microsoft Outlook | Microsoft Corporation |
| .SSI | Adobe Systems Incorporated | File con immagini raster | Adobe Dreamweaver Server Side Include File | Adobe Dreamweaver | Adobe Systems Incorporated |
| .STG | Microsoft Corporation | File con immagini raster | ActiveSync Backup File | Microsoft ActiveSync | Microsoft Corporation |
| .SUL | Unknown Developer | File con immagini raster | GFA Raytrace Image | GFA Raytrace | Unknown Developer |
| .SUN | Sun Microsystems | File con immagini raster | Sun Raster Graphic File | GIMP | The GIMP Development Team |
| .SUNIFF | Sun Microsystems | File con immagini raster | Sun TAAC Image | XnView MP | XnSoft |
| .SUP | Unknown Developer | File con immagini raster | Subtitle Bitmap File | IfoEdit | Open Source |
| .SVA | Viz Media | File con immagini raster | Manga Browser Comic File | Sharp Manga Browser for SHONEN JUMP | Viz Media |
| .SVM | Star Division | File con immagini raster | StarView Metafile | Apache OpenOffice | Apache Software Foundation |
| .SVS | Nintendo | File con immagini raster | Game Boy Advance Saved State File | Game Boy Advance | Nintendo |
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