| .DWC | Emulex Corporation | File di giochi | Emulex DWC Firmware Update File | Emulex lputil | Emulex Corporation |
| .DWD | DiamondWare Ltd. | File di giochi | DiamondWare Digital Audio File | Wi-Fone | DiamondWare Ltd. |
| .DX | Digital Equipment Corporation | File di giochi | DEC WPS Plus File | Microsoft Notepad | Microsoft Corporation |
| .DXM | Ion Storm Inc. | File di giochi | Deus Ex Map File | Deus Ex: Game of the Year Edition | Ion Storm Inc. |
| .DXS | Eidos Interactive | File di giochi | Deus Ex Saved Game | Deus Ex: Game of the Year Edition | Ion Storm Inc. |
| .DXT | LucasArts Entertainment Company, LLC | File di giochi | LucasArts The Secret Of Monkey Island: Special Edition Texture | The Secret Of Monkey Island | LucasArts Entertainment Company, LLC |
| .DZ | Digital Extremes | File di giochi | Land Of The Dead Level File | Unreal Tournament | Epic Games |
| .E3 | DPT Corp | File di giochi | Think3 Thinkdesign CAD Document | ThinkDesign Suite | DPT Corp |
| .EA3 | Electronic Arts | File di giochi | FIFA 2001 Game Data | FIFA 2001 | EA Sports |
| .EAC | Emurasoft, Inc. | File di giochi | EmEditor Auto-Completion Data | EmEditor | Emurasoft, Inc. |
| .EBP | Jes-Soft | File di giochi | Jes-Soft Sports Play Description | Jes-Soft Playbook | Jes-Soft |
| .EBZ | Intersystem Concepts | File di giochi | Empire Builder Pronto Saved Game | Empire Builder Pronto | Intersystem Concepts |
| .ECL | Team Shanghai Alice | File di giochi | Touhou Stage Script | Touhou ToolKit | Touhou Patch Center |
| .ECW | ESRI (Environmental Systems Research Institute) | File di giochi | Enhanced Compression Wavelet Image | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .EDT | Adobe Systems Incorporated | File di giochi | Adobe eBook Download Settings | Adobe Digital Editions | Adobe Systems Incorporated |
| .EES | Sierra Entertainment | File di giochi | Empire Earth Scenario Data | Empire Earth | Sierra Entertainment |
| .EFF | The Hotline Group | File di giochi | eFileFolders File Format | eFileFolders | The Hotline Group |
| .EFT | Cay Horstmann | File di giochi | ChiWriter High Resolution Screen Font | ChiWriter | Cay Horstmann |
| .EFX | j2 Global, Inc. | File di giochi | eFax Document | j2 Global Communications eFax | j2 Global, Inc. |
| .EGM | Pangea Software, Inc. | File di giochi | Pangea Enigmo Custom Game Data | Pangea Software Enigmo | Pangea Software, Inc. |
| .EGT | EagleGet | File di giochi | EagleGet Temporary File | EagleGet | EagleGet |
| .EIC | Nitro Games | File di giochi | East Indian Company Save Game File | East India Company | Nitro Games |
| .EK6 | Open Source | File di giochi | Generation 6 Pokémon Save File | PKHeX | Open Source |
| .EKV | Valve | File di giochi | Left 4 Dead Game Data | Left 4 Dead | Valve |
| .EKX | Open Source | File di giochi | Encrypted 3DS Pokémon Save File | PKHeX | Open Source |
| .ELF | Nintendo | File di giochi | Nintendo Wii Game File | Dolphin (emulator) | Dolphin Emulator Project |
| .ELM | Open Source | File di giochi | Eternal Lands Map File | Eternal Lands | Open Source |
| .EMI | Blitwise Productions | File di giochi | Pocket Tanks Emitter File | Pocket Tanks | Blitwise Productions |
| .EMM | MindMaple Inc. | File di giochi | MindMaple Map | MindMaple | MindMaple Inc. |
| .ENC | Smith Micro Software | File di giochi | Encoded Data File | Smith Micro StuffIt Deluxe | Smith Micro Software |
| .END | Corel | File di giochi | CorelDRAW Arrow-head Definition Data | CorelDRAW Graphics Suite | Corel |
| .ENG | Unknown Developer | File di giochi | Chess Engine | ChessMaster | Ubisoft Blue Byte |
| .ENV | Adobe Systems Incorporated | File di giochi | Adobe Dictionary Data File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .EPC | Sumo Digital Ltd. | File di giochi | Doctor Who Game Data File | BBC Doctor Who: The Adventure Games | Sumo Digital Ltd. |
| .EPK | LG Electronics | File di giochi | LG Firmware Package | epk2extract | openlgtv |
| .ERB | Open Source | File di giochi | Ruby ERB Script | Microsoft Notepad | Microsoft Corporation |
| .ERF | BioWare | File di giochi | BioWare Entity Resource File | BioWare Neverwinter Nights | BioWare |
| .ERP | Future Games | File di giochi | Alter Ego Game Archive | Alter Ego | Future Games |
| .ES | Interscape | File di giochi | ECHOSPEECH File | ECHOSPEECH | Interscape |
| .ESG | Pangea Software, Inc. | File di giochi | Enigmo Saved Game File | Pangea Software Enigmo | Pangea Software, Inc. |
| .ESI | Open Source | File di giochi | Escape Level Index File | Escape | Open Source |
| .ESM | Bethesda Softworks | File di giochi | Bethesda Softworks Master File | Bethesda Softworks TES Construction Set | Bethesda Softworks |
| .ESN | Epic Games | File di giochi | Unreal Engine Language Localization | Unreal Tournament | Epic Games |
| .ESP | Bethesda Softworks | File di giochi | Elder Scrolls Plugin File | Bethesda Softworks TES Construction Set | Bethesda Softworks |
| .ESS | Bethesda Softworks | File di giochi | The Elder Scrolls Saved Game | Skyrim VR | Bethesda Softworks |
| .ESX | Xactware Solutions | File di giochi | Xactimate Insurance Claims Estimate | Xactimate | Xactware Solutions |
| .EU4 | Paradox Development Studio | File di giochi | Europa Universalis IV Saved Game | Europa Universalis IV | Paradox |
| .EUR | Capcom | File di giochi | Monster Hunter Freedom Unite EU Region Saved Game | Monster Hunter Freedom Unite | Capcom |
| .EVP | Miracle Castle | File di giochi | Talisman Online Game Data | Talisman Online | Miracle Castle |
| .EWL | Green Eclipse | File di giochi | EclipseCrossword Word List File | Green Eclipse EclipseCrossword | Green Eclipse |
| .EXC | Lionhead Studios | File di giochi | Black & White Zone File | Lionhead Studios Black and White | Lionhead Studios |
| .EXL | SysTools Solutions | File di giochi | Export Lister File | SysTools Export Notes | SysTools Solutions |
| .EXS | Apple | File di giochi | EXS Instrument | Apple Logic Pro | Apple |
| .F2K | Microsoft Corporation | File di giochi | Freecell 2000 File | Freecell 2000 | Microsoft Corporation |
| .FAC | Newera Software Technology, Inc. | File di giochi | FACE Graphic File | Graphics Converter Pro | Newera Software Technology, Inc. |
| .FAM | Electronic Arts | File di giochi | The Sims Family Data Game File | The Sims | Electronic Arts |
| .FAR | Electronic Arts | File di giochi | The Sims Archive File | Dragon UnPACKer | Open Source |
| .FBI | Cavedog | File di giochi | Total Annihilation Main Unit Definition File | Total Annihilation | Cavedog |
| .FCE | EaSynth Solution | File di giochi | ForeUI Custom Element File | EaSynth Solution ForeUI | EaSynth Solution |
| .FCM | fcraft.net | File di giochi | fCraft World File | fCraft | fcraft.net |
| .FCR | Michigan Department of Community Health | File di giochi | Cost Report Data File | Electronic Cost Report for Microsoft Excel | Michigan Department of Community Health |
| .FCS | Interscape | File di giochi | Flow Cytometry Standard File | Verity Software House V-Comp | Interscape |
| .FDS | Adobe Systems Incorporated | File di giochi | JetForm FormFlow Data File | JetForm FormFlow | Adobe Systems Incorporated |
| .FF | Activision | File di giochi | Call Of Duty 4 Fast File | Call of Duty 4: Modern Warfare | Activision |
| .FF7 | Square Enix | File di giochi | Final Fantasy VII Saved Game | Final Fantasy | Square Enix |
| .FFD | Microsoft Corporation | File di giochi | SharePoint FFDDumper Log | Microsoft Notepad | Microsoft Corporation |
| .FFN | Electronic Arts | File di giochi | FIFA World Cup Game Data Fe Art Data | FIFA World Cup | Electronic Arts |
| .FGD | Valve | File di giochi | Forge Game Data File | Valve Source SDK | Valve |
| .FIG | Open Source | File di giochi | Xfig Drawing | Winfig | Andreas Schmidt |
| .FL | Microsoft Corporation | File di giochi | Freelancer Saved Game File | Freelancer | Microsoft Corporation |
| .FLD | Open Source | File di giochi | YSFLIGHT Field File | YSFlight | Open Source |
| .FML | Headlight Software | File di giochi | GetRight File Mirror List | GetRight | Headlight Software |
| .FORGE | Ubisoft | File di giochi | Assassin's Creed Game Data File | Assassin's Creed | Ubisoft |
| .FOS | Bethesda Softworks | File di giochi | Fallout 3 Saved Game | Fallout 3 | Bethesda Softworks |
| .FOW | FormalSoft, Inc. | File di giochi | Family Origins Database | Family Origins | FormalSoft, Inc. |
| .FOX | Dragon's Eye Productions | File di giochi | Furcadia Art File | Furcadia | Dragon's Eye Productions |
| .FP2 | Piotr Fusik | File di giochi | Funpaint Picture Image | Recoil | Piotr Fusik |
| .FPG | The Game Creators | File di giochi | FPS Creator Game Project File | FBS Creator | The Game Creators |
| .FPK | Interscape | File di giochi | Civilization 4 Data File | Take-Two Interactive Civilization 3 | Interscape |
| .FPP | The Eclipse Foundation | File di giochi | Fortran Source Code | MacroMates TextMate | MacroMates |
| .FPS | The Game Creators | File di giochi | FPS Creator Segment File | FPS Creator | The Game Creators |
| .FRA | Electronic Arts | File di giochi | FIFA World Cup Game Data | FIFA World Cup | Electronic Arts |
| .FRC | Dovetail Games | File di giochi | FS Recorder File | FS Recorder | Unknown Developer |
| .FRM | Oracle Corporation | File di giochi | MySQL Database Format File | MySQL | Oracle Corporation |
| .FRW | Atari Corporation | File di giochi | RollerCoaster Tycoon Fireworks Source Data | RollerCoaster Tycoon | Chris Sawyer |
| .FRZ | Snes9x Team | File di giochi | Snes9x Saved State | Snes9x | Snes9x Team |
| .FS2 | Interplay Entertainment | File di giochi | FreeSpace 2 Saved Mission File | Interplay FreeSpace 2 | Interplay Entertainment |
| .FSC | ProFantasy Software Ltd | File di giochi | Campaign Cartographer File | Campaign Cartographer 3 | ProFantasy Software Ltd |
| .FSG | Open Source | File di giochi | FreeCol Saved Game File | FreeCol | Open Source |
| .FSK | Atari Corporation | File di giochi | Atari 8-bit Cassette Image | A8CAS | SourceForge |
| .FST | Image-Line | File di giochi | FL Studio State File | Image-Line FL Studio | Image-Line |
| .FTL | Apache Software Foundation | File di giochi | FreeMarker Template File | FreeMaker | Apache Software Foundation |
| .FUK | Running With Scissors | File di giochi | Postal 2 Map File | Postal 2 | Running With Scissors |
| .FXT | Rockstar Games | File di giochi | Grand Theft Auto Fake Text File | Sanny Builder | Open Source |
| .G3X | Knife Edge Software | File di giochi | RealFlight Content File | RealFlight | Knife Edge Software |
| .G4B | Open Source | File di giochi | Sokoban++ Level File | Sokoban | Open Source |
| .GAM | Nintendo | File di giochi | Saved Game File | No Cash GBA (No$GBA) | Martin Korth |
| .GAME | Apple | File di giochi | Apple Chess Saved Game | Apple Chess | Apple |
| .GAR | GIANTS Software | File di giochi | Farming Simulator Game Archive File | Farming Simulator | GIANTS Software |
| .GAX | Microsoft Corporation | File di giochi | Age Of Empires II Saved Game | Microsoft Age of Empires | Ensemble Studios |
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