| .E | OpenEuphoria | File sviluppatore | Euphoria Include File | Rapid Deployment Euphoria | OpenEuphoria |
| .EAF | Max Planck Institute for Psycholinguistics | File sviluppatore | ELAN Annotation Format | ELAN | Max Planck Institute for Psycholinguistics |
| .EBC | SourceForge | File sviluppatore | MediaBASIC Compiled Project | MediaBASIC | SourceForge |
| .EBS | Psychology Software Tools, Inc. | File sviluppatore | E-Run Version 1 Script File | E-Prime | Psychology Software Tools, Inc. |
| .EBX | IBM | File sviluppatore | Rational Rose 98 Compiled Script | Rational Rose | IBM |
| .EC | Informix Corporation | File sviluppatore | Informix ESQL/C Source | IBM Informix | IBM |
| .ECP | Intelitek | File sviluppatore | EasyC Project File | EasyC | Intelitek |
| .ECT | Yozosoft | File sviluppatore | Yozo Office Chart Template File | Yozosoft Yozo Office | Yozosoft |
| .EDM | Adobe Systems Incorporated | File sviluppatore | Adobe Extension Data Markup Language File | Adobe Dreamweaver | Adobe Systems Incorporated |
| .EDML | Adobe Systems Incorporated | File sviluppatore | Adobe Extension Data Markup Language File | Adobe Dreamweaver | Adobe Systems Incorporated |
| .EDMX | Microsoft Corporation | File sviluppatore | ADO.NET Entity Data Model Designer File | Microsoft Visual Studio | Microsoft Corporation |
| .EEP | Open Source | File sviluppatore | EEPROM Data File | HHD Hex Editor | HHD Software |
| .EFD | Parallels | File sviluppatore | Parallels Desktop Related File | Parallels Desktop for Mac | Parallels |
| .EFG | Open Source | File sviluppatore | Gambit Extensive Game Format | Gambit | Open Source |
| .EKM | Symbol Dynamics LLC | File sviluppatore | EXP Macro | EXP | Symbol Dynamics LLC |
| .EL | GNU Project | File sviluppatore | Emacs Lisp Code File | GNU Emacs | GNU Project |
| .ELA | TradeStation | File sviluppatore | EasyLanguage Archive | TradeStation | TradeStation |
| .ELC | GNU Project | File sviluppatore | Emacs Compiled Lisp File | GNU Emacs | GNU Project |
| .ELD | DIAL | File sviluppatore | Eulumdat Formatted Luminaire Data File | DIAL DIALux | DIAL |
| .ELK | Altium | File sviluppatore | Altium Designer Linker Error Message | Altium Designer | Altium |
| .EMV | National Instruments | File sviluppatore | LabVIEW Configuration File | LabVIEW | National Instruments |
| .ENT | Syncro Soft | File sviluppatore | External Entity | Oxygen XML Editor 19 | Syncro Soft |
| .EPJ | Grass Valley | File sviluppatore | EDIUS Pro Project File | Thomson EDIUS | Grass Valley |
| .EQN | Altium | File sviluppatore | GAL Equation File | Altium Designer | Altium |
| .ERB | Open Source | File sviluppatore | Ruby ERB Script | Microsoft Notepad | Microsoft Corporation |
| .ERL | INCA Internet | File sviluppatore | GameGuard Error Log File | GameGuard | INCA Internet |
| .ES | Interscape | File sviluppatore | ECHOSPEECH File | ECHOSPEECH | Interscape |
| .EU | OpenEuphoria | File sviluppatore | Euphoria Include Data | Rapid Deployment Euphoria | OpenEuphoria |
| .EW | OpenEuphoria | File sviluppatore | Euphoria Source Code File | Microsoft Notepad | Microsoft Corporation |
| .EX | Symantec Corporation | File sviluppatore | Norton Ghost Template Data | Symantec Ghost Solution Suite | Symantec Corporation |
| .EXE_ | Open Source | File sviluppatore | Emu8086 Assembly Source Code | 8086 Microprocessor Emulator | Open Source |
| .EXL | SysTools Solutions | File sviluppatore | Export Lister File | SysTools Export Notes | SysTools Solutions |
| .EXP | Unknown Developer | File sviluppatore | Symbols Export File | Microsoft Visual Studio | Microsoft Corporation |
| .EXU | Open Source | File sviluppatore | Euphoria For Linux Source Code | Euphoria | Open Source |
| .EXW | OpenEuphoria | File sviluppatore | Euphoria Source Code File | Microsoft Notepad | Microsoft Corporation |
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