| .SBL | Adobe Systems Incorporated | File grafici | Shockwave Flash Object | Apache OpenOffice | Apache Software Foundation |
| .SCRIPT | Unknown Developer | File eseguibili | Generic Script File | OpenOffice Writer | Apache Software Foundation |
| .SDA | Oracle Corporation | File con immagini vettoriali | StarOffice Drawing | Apache OpenOffice | Apache Software Foundation |
| .SDC | Stardock Corporation | File backup | Stardock Central Download Archive | Apache OpenOffice | Apache Software Foundation |
| .SDD | Programming Sunrise | File di dati | Smart Diary Suite Data File | Apache OpenOffice | Apache Software Foundation |
| .SDI | Intuit, Inc. | File di dati | QuickBooks Data File | Apache OpenOffice | Apache Software Foundation |
| .SDP | Oracle Corporation | File di dati | StarOffice Presentation File | Apache OpenOffice | Apache Software Foundation |
| .SDS | Oracle Corporation | File di dati | OpenOffice.org Chart | Apache OpenOffice | Apache Software Foundation |
| .SDV | Pinnacle Systems Inc. | File video | Studio DV Project File | Apache OpenOffice | Apache Software Foundation |
| .SDW | LizardTech | File di GIS | MrSID World File | Apache OpenOffice | Apache Software Foundation |
| .SFS | Open Source | File compressi | Squashfs File Archive | Apache OpenOffice | Apache Software Foundation |
| .SILK | Microsoft Corporation | File con fogli di calcolo | Microsoft Excel Symbolic Link Format | Apache OpenOffice Calc | Apache Software Foundation |
| .SKI | Motorola | File di settaggi | Motorola Phone Skin File | Apache OpenOffice | Apache Software Foundation |
| .SKV | Microsoft Corporation | File di dati | Semicolon Separated Values File | Apache OpenOffice | Apache Software Foundation |
| .SMF | Oracle Corporation | File di testo | StarMath Formula File | Apache OpenOffice | Apache Software Foundation |
| .SMS | Sega | File di giochi | Sega Master System ROM | Apache OpenOffice | Apache Software Foundation |
| .SOB | Apache Software Foundation | File con immagini raster | OpenOffice.org Impress Bimap Styles File | Apache OpenOffice | Apache Software Foundation |
| .SOC | Apache Software Foundation | File di settaggi | OpenOffice.org Configuration File | Apache OpenOffice | Apache Software Foundation |
| .SOD | id Software | File di giochi | Spear Of Destiny Data File | Apache OpenOffice | Apache Software Foundation |
| .SOF | Apache Software Foundation | File di dati | Colour Palettes And Various Style Elements File | Apache OpenOffice | Apache Software Foundation |
| .SOG | Apache Software Foundation | File di dati | Apache OpenOffice (OpenOffice.org) Colour Palettes | Apache OpenOffice | Apache Software Foundation |
| .SRS | Microsoft Corporation | File di settaggi | Outlook Send/Receive Settings File | Apache OpenOffice | Apache Software Foundation |
| .STC | Adobe Systems Incorporated | File web | Contribute Connection Key File | Apache OpenOffice | Apache Software Foundation |
| .STD | Oracle Corporation | File con immagini vettoriali | Apache OpenOffice Drawing Template | Apache OpenOffice | Apache Software Foundation |
| .STE | Adobe Systems Incorporated | File di settaggi | Dreamweaver Site Settings File | OpenOffice Writer | Apache Software Foundation |
| .STI | Oracle Corporation | File di dati | StarOffice Presentation Template | Apache OpenOffice | Apache Software Foundation |
| .STM | Microsoft Corporation | File di dati | Exchange Streaming Media File | Apache OpenOffice Calc | Apache Software Foundation |
| .STW | Oracle Corporation | File di testo | StarOffice Document Template | Apache OpenOffice | Apache Software Foundation |
| .SVM | Star Division | File con immagini raster | StarView Metafile | Apache OpenOffice | Apache Software Foundation |
| .SVN | Apache Software Foundation | File di dati | Subversion Data File | Subversion | Apache Software Foundation |
| .SWX | Apache Software Foundation | File di testo | OpenOffice.org 1.0 Text Document | Apache OpenOffice | Apache Software Foundation |
| .SXC | Sun Microsystems | File con fogli di calcolo | StarOffice Calc Spreadsheet | Apache OpenOffice Calc | Apache Software Foundation |
| .SXD | ESRI | File di GIS | ArcScene Document | Apache OpenOffice | Apache Software Foundation |
| .SXG | Oracle Corporation | File di testo | Apache OpenOffice Master Document | Apache OpenOffice | Apache Software Foundation |
| .SXI | Oracle Corporation | File di dati | StarOffice Impress Presentation | Apache OpenOffice | Apache Software Foundation |
| .SXW | Oracle Corporation | File di testo | StarOffice Writer Document | Apache OpenOffice | Apache Software Foundation |
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