| .R3D | Various Developers | File video | REDCODE Video File | Adobe Premiere Pro CC | Adobe Systems Incorporated |
| .RAF | Fuji Xerox | File Videocamera non elaborati | Fuji RAW Image File | Adobe Photoshop Elements | Adobe Systems Incorporated |
| .RAW | Unknown Developer | File Videocamera non elaborati | Raw Image Data File | Adobe Photoshop Elements | Adobe Systems Incorporated |
| .RDT | Adobe Systems Incorporated | File di dati | Adobe Captivate RoboDemo Template File | Adobe Captivate | Adobe Systems Incorporated |
| .RF | Adobe Systems Incorporated | File di dati | Adobe FrameMaker Document | Adobe FrameMaker | Adobe Systems Incorporated |
| .RFR | Adobe Systems Incorporated | File di dati | Adobe Photoshop Frame Filter | Adobe Photoshop | Adobe Systems Incorporated |
| .RL4 | Various Developers | File con immagini raster | Bitmap Image File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .RL8 | Microsoft Corporation | File grafici | Windows Bitmap Image | Adobe Photoshop | Adobe Systems Incorporated |
| .RLE | Various Developers | File con immagini raster | Run Length Encoded Bitmap | Adobe Photoshop Elements | Adobe Systems Incorporated |
| .RMD | Thomson Reuters Corporation | File di dati | Reference Manager Data File | Adobe Premiere Pro CC | Adobe Systems Incorporated |
| .RMF | Valve | File di giochi | Hammer Rich Map Format | Adobe Acrobat DC | Adobe Systems Incorporated |
| .RPF | Rockstar Games | File di giochi | Grand Theft Auto Data File | Adobe After Effects | Adobe Systems Incorporated |
| .RPLN | Adobe Systems Incorporated | File con plugin | InDesign Required Plug-in File | Adobe InDesign | Adobe Systems Incorporated |
| .RSA | Various Developers | File vari | RSA Certificate File | Adobe Photoshop Elements | Adobe Systems Incorporated |
| .RTA | Adobe Systems Incorporated | File di dati | RoboHelp RTA Data File | Adobe RoboHelp | Adobe Systems Incorporated |
| .RTK | Adobe Systems Incorporated | File di dati | Adobe RoboHelp Configuration File | Adobe RoboHelp | Adobe Systems Incorporated |
| .RVL | muvee | File video | Muvee Reveal X Project File | Adobe Revel | Adobe Systems Incorporated |
| .RWL | Leica Biosystems | File Videocamera non elaborati | Leica D-Lux 4 RAW Image | Adobe Photoshop | Adobe Systems Incorporated |
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