| .RAS | Remedy Entertainment | Fichiers de jeu | Remedy Archive System File | Audacity | Open Source |
| .RAV | Nevrona Designs | Fichiers de jeu | Rave Reports Project File | Rave Reports | Nevrona Designs |
| .RAW | Unknown Developer | Fichiers de jeu | Raw Image Data File | MacPhun ColorStrokes | Macphun |
| .RB | Larian Studios | Fichiers de jeu | Divinity: Original Sin Game Data | Divinity: Original Sin | Larian Studios |
| .RBJ | Marco Pontello | Fichiers de jeu | XRK Compiled Redcode Object File | Extra Redcode Kit | Open Source |
| .RBN | Richard Pavlicek | Fichiers de jeu | Richard’s Bridge Notation File | Unknown Software | Unknown Developer |
| .RBXL | Roblox Corporation | Fichiers de jeu | ROBLOX Location File | ROBLOX | Roblox Corporation |
| .RBXM | Roblox Corporation | Fichiers de jeu | ROBLOX Model | ROBLOX | Roblox Corporation |
| .RBZ | Trimble Inc. | Fichiers de jeu | SketchUp Plugin | SketchUp | Trimble Inc. |
| .RCC | Angus Johnson | Fichiers de jeu | Resource Script File | Microsoft Visual Studio | Microsoft Corporation |
| .RCS | RandomControl | Fichiers de jeu | RandomControl Scene File | RandomControl Fryrender | RandomControl |
| .RD2 | Codemasters | Fichiers de jeu | TOCA Race Driver 2 Saved Game File | TOCA Race Driver 2 | Codemasters |
| .RDA | Open Source | Fichiers de jeu | R Data File | R | The R Foundation |
| .REC | TOPFIELD Co., Ltd. | Fichiers de jeu | Topfield PVR Recording | Squared 5 MPEG Streamclip | Open Source |
| .REL | Nintendo | Fichiers de jeu | Relocatable Module File | Stage Switcher | Unknown Developer |
| .REP | Rockstar Games | Fichiers de jeu | Grand Theft Auto Replay File | Grand Theft Auto III | Rockstar Games |
| .RES | Valve | Fichiers de jeu | Valve Resource File | Half-Life | Valve |
| .RESOURCES | Microsoft Corporation | Fichiers de jeu | Microsoft Visual Studio Resource | Microsoft Visual Studio | Microsoft Corporation |
| .REZ | Monolith Productions | Fichiers de jeu | Lithtech Game Engine Resource File | Dragon UnPACKer | Open Source |
| .RFA | Autodesk, Inc. | Fichiers de jeu | Revit Family File | AutoCAD Architecture | Autodesk, Inc. |
| .RFD | Recogniform Technologies | Fichiers de jeu | Recogniform Form Designer File | Recogniform | Recogniform Technologies |
| .RFM | Beatnik | Fichiers de jeu | Rich Music Format File | Unknown Software | Unknown Developer |
| .RGD | Redbeet Interactive | Fichiers de jeu | Raft Saved Game File | Raft | Redbeet Interactive |
| .RGI | RealNetworks | Fichiers de jeu | RealArcade Game Installer | RealArcade | RealNetworks |
| .RGM | Relic Entertainment | Fichiers de jeu | Essence Game Engine Model File | Warhammer 40K Dawn of War | Relic Entertainment |
| .RGP | RealNetworks | Fichiers de jeu | RealArcade Game Package | RealArcade | RealNetworks |
| .RGT | Relic Entertainment | Fichiers de jeu | Relic Entertainment Game Texture File | Corsix's Mod Studio | Open Source |
| .RIM | BioWare | Fichiers de jeu | BioWare Resource Image File | BioWare Neverwinter Nights | BioWare |
| .RKP | Devolutions | Fichiers de jeu | RemoteKeys Profile File | Remote Desktop Manager | Devolutions |
| .RKV | Krome Studios | Fichiers de jeu | Star Wars The Clone Wars Republic Heroes Game Archive File | Star Wars: The Clone Wars-- Republic Heroes | Krome Studios |
| .RL | R.LAB | Fichiers de jeu | R.viewer List File | R.viewer | R.LAB |
| .RME | Square Enix | Fichiers de jeu | Final Fantasy Audio Data | Final Fantasy XI | Square Enix |
| .RMF | Valve | Fichiers de jeu | Hammer Rich Map Format | Valve Hammer Editor | Valve |
| .RMO | Iron Crown Enterprises | Fichiers de jeu | Rolemaster Character Data | Rolemaster | Iron Crown Enterprises |
| .ROD | RIB Software | Fichiers de jeu | RIB Office Database File | RIB office | RIB Software |
| .ROS | Jon Taylor | Fichiers de jeu | BattleScribe Roster Editor File | BattleScribe | Jon Taylor |
| .ROT | Sierra Entertainment | Fichiers de jeu | Homeworld 2 Graphics File | Homeworld 2 | Sierra Entertainment |
| .RP2 | Cloanto Corporation | Fichiers de jeu | RetroPlatform Player Program Archive | Amiga Forever | Cloanto Corporation |
| .RPF | Rockstar Games | Fichiers de jeu | Grand Theft Auto Data File | Grand Theft Auto IV | Rockstar Games |
| .RPL | Nabi Studios | Fichiers de jeu | Toribash Replay File | Toribash | Nabi Studios |
| .RPX | Cemu | Fichiers de jeu | Wii U Game | Cemu | Cemu |
| .RPY | Team Shanghai Alice | Fichiers de jeu | Touhou Project Replay File | Touhou Project | Team Shanghai Alice |
| .RPYC | Tom "PyTom" Rothamel | Fichiers de jeu | Ren'Py Compiled Script | Ren'Py | Tom "PyTom" Rothamel |
| .RRS | Electronic Arts | Fichiers de jeu | Road Rash Saved Game Position | Road Rash | Electronic Arts |
| .RSD | Rosetta Stone | Fichiers de jeu | Rosetta Stone Data File | Rosetta Stone Language Learning | Rosetta Stone |
| .RSG | Surreal Software | Fichiers de jeu | Drakan: Order Of The Flame File | Drakan: Order Of The Flame | Surreal Software |
| .RSH | Relic Entertainment | Fichiers de jeu | Warhammer 40,000 Texture | Warhammer 40K Dawn of War | Relic Entertainment |
| .RUN | Open Source | Fichiers de jeu | Linux Executable File | Linux | Open Source |
| .RVI | Eidos Interactive | Fichiers de jeu | Revenant Game Archive | Revenant | Cinematix Studios, Inc. |
| .RVM | Eidos Interactive | Fichiers de jeu | Revenant Game Archive | Revenant | Cinematix Studios, Inc. |
| .RVN | Cyan | Fichiers de jeu | Riven Saved Game | Riven | Cyan |
| .RVS | Eidos Interactive | Fichiers de jeu | Revenant Game Archive | Revenant | Cinematix Studios, Inc. |
| .RW | Open Source | Fichiers de jeu | BVE Trainsim Railway Definition File | CyberLink PowerDVD | CyberLink |
| .RWD | NRG Systems | Fichiers de jeu | NRG Raw Wind Data File | Symphonie Data Retriever | NRG Systems |
| .RWS | Ludeon Studios | Fichiers de jeu | RimWorld Game Save File | Ludeon Studios RimWorld | Ludeon Studios |
| .RX3 | EA Maxis | Fichiers de jeu | FIFA Texture File | FIFA 14 | EA Sports |
| .RXDATA | Kadokawa Corporation | Fichiers de jeu | RMXP Data File | Enterbrain RPG Maker XP (RMXP) | Kadokawa Corporation |
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