| .S11 | Interplay Entertainment | Fichiers de jeu | Descent 2 Game Data | Unsealer | Oracle Corporation |
| .S1A | Oracle Corporation | Fichiers encodés | Sealed Acrobat Document | Unsealer | Oracle Corporation |
| .S1E | SealedMedia | Fichiers encodés | Sealed Excel Worksheet File | Unsealer | Oracle Corporation |
| .S1M | Yamaha Corporation | Fichiers audio | Yamaha EX5 Waveform Data | Unsealer | Oracle Corporation |
| .S1N | SealedMedia | Fichiers cryptés | Sealed PNG Graphic File | Unsealer | Oracle Corporation |
| .SAL | Oracle Corporation | Fichiers de développeurs | SQL Application Language Source Code | MySQL | Oracle Corporation |
| .SDA | Oracle Corporation | Fichiers d’image vectorielle | StarOffice Drawing | StarOffice | Oracle Corporation |
| .SDD | Programming Sunrise | Fichiers de données | Smart Diary Suite Data File | StarOffice | Oracle Corporation |
| .SDG | Golden Software LLC | Fichiers CAD | Strater Project File | StarOffice | Oracle Corporation |
| .SDM | Oracle Corporation | Fichiers textes | StarOffice Mail Message | StarOffice | Oracle Corporation |
| .SDOC | Samsung Electronics | Fichiers de données | Samsung Memo File | Oracle IRM Desktop | Oracle Corporation |
| .SDP | Oracle Corporation | Fichiers de données | StarOffice Presentation File | StarOffice | Oracle Corporation |
| .SDS | Oracle Corporation | Fichiers de données | OpenOffice.org Chart | StarOffice | Oracle Corporation |
| .SECURITY | Oracle Corporation | Fichiers de données | Javasoft Jre 1.3 Lib Security Data | Java | Oracle Corporation |
| .SEM | Alpha Software | Fichiers de développeurs | Alpha Five Set Data Dictionary Memo File | Unsealer | Oracle Corporation |
| .SEML | Oracle Corporation | Fichiers divers | Sealed EML Document | Oracle IRM Desktop | Oracle Corporation |
| .SFS | Open Source | Fichiers compressés | Squashfs File Archive | StarOffice | Oracle Corporation |
| .SGV | Oracle Corporation | Fichiers graphiques | StarOffice StarDraw 2.0 Picture Image File | StarOffice | Oracle Corporation |
| .SIZ | Oracle Corporation | Fichiers de paramètres | Oracle 7 Configuration File | Oracle Database | Oracle Corporation |
| .SJP | Oracle Corporation | Fichiers encodés | Sealed JPG File | Oracle IRM Desktop | Oracle Corporation |
| .SJPG | Oracle Corporation | Fichiers encodés | Sealed JPG File | Oracle IRM Desktop | Oracle Corporation |
| .SMH | Oracle Corporation | Fichiers textes | Sealed MHT Document | Unsealer | Oracle Corporation |
| .SPD | AutoDesSys, Inc. | Fichiers divers | Form-Z Suspended Render Data | Unsealer | Oracle Corporation |
| .SPDF | Oracle Corporation | Fichiers encodés | Sealed PDF File | Oracle IRM Desktop | Oracle Corporation |
| .SPN | Corel | Fichiers de paramètres | Corel WordPerfect Distribution Definition | Unsealer | Oracle Corporation |
| .SPP | Serif | Fichiers Raster Image | Serif PhotoPlus Picture File | Unsealer | Oracle Corporation |
| .SPS | IBM | Fichiers de données | SPSS Program File | Oracle Database | Oracle Corporation |
| .SQL | Various Developers | Fichiers de base de données | Structured Query Language Data File | MySQL | Oracle Corporation |
| .SQR | Oracle Corporation | Fichiers de données | SQL Program File | MySQL | Oracle Corporation |
| .SR | Sun Microsystems | Fichiers Raster Image | Sun Raster Image File | Sun Operating System | Oracle Corporation |
| .SSW | Sony Mobile Communications | Fichiers divers | Sony Ericsson Firmware File | Unsealer | Oracle Corporation |
| .STD | Oracle Corporation | Fichiers d’image vectorielle | Apache OpenOffice Drawing Template | StarOffice | Oracle Corporation |
| .STI | Oracle Corporation | Fichiers de données | StarOffice Presentation Template | StarOffice | Oracle Corporation |
| .SUN | Sun Microsystems | Fichiers Raster Image | Sun Raster Graphic File | Sun Operating System | Oracle Corporation |
| .SXD | ESRI | Fichiers GIS | ArcScene Document | StarOffice | Oracle Corporation |
| .SXG | Oracle Corporation | Fichiers textes | Apache OpenOffice Master Document | StarOffice | Oracle Corporation |
| .SXL | SealedMedia | Fichiers encodés | Sealed Excel Worksheet File | Unsealer | Oracle Corporation |
| .SXLS | Oracle Corporation | Fichiers de feuille de calcul | Sealed Excel Spreadsheet | Oracle IRM Desktop | Oracle Corporation |
| .SXML | Oracle Corporation | Fichiers encodés | Sealed XML File | Oracle IRM Desktop | Oracle Corporation |
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