| .SAV | Nintendo | Varmuuskopiointitiedostot | Saved Game File | No Cash GBA (No$GBA) | Martin Korth |
| .SBAK | Conquer Internet Ltd. | Varmuuskopiointitiedostot | Ideal Summary Sheets Standard Backup (Non-Encrypted) | Ideal Summary Sheets | Conquer Internet Ltd. |
| .SBB | Microsoft Corporation | Varmuuskopiointitiedostot | Office Accounting Company Backup File | Microsoft Office Accounting | Microsoft Corporation |
| .SBK | SwishZone | Varmuuskopiointitiedostot | SWiSH Project Backup File | SWiSH Max | SwishZone |
| .SBS | Allegorithmic | Varmuuskopiointitiedostot | Substance Package | Substance Designer | Allegorithmic |
| .SBU | Samsung Electronics | Varmuuskopiointitiedostot | Samsung Backup File | Samsung Kies | Samsung Electronics |
| .SDC | Stardock Corporation | Varmuuskopiointitiedostot | Stardock Central Download Archive | Stardock Central | Stardock Corporation |
| .SIK | Microsoft Corporation | Varmuuskopiointitiedostot | Microsoft Word Backup | Microsoft Word | Microsoft Corporation |
| .SIM | Valve | Varmuuskopiointitiedostot | Steam Game Backup Information File | Steam | Valve |
| .SIS | Valve | Varmuuskopiointitiedostot | Steam Game Backup Information File | Steam | Valve |
| .SKB | Trimble Inc. | Varmuuskopiointitiedostot | SketchUp Backup Document | SketchUp | Trimble Inc. |
| .SME | Samsung Electronics | Varmuuskopiointitiedostot | Samsung Mobile Backup File | Samsung Kies | Samsung Electronics |
| .SMEA | Samsung Electronics | Varmuuskopiointitiedostot | Samsung Kies Messages Backup | Samsung Kies | Samsung Electronics |
| .SN1 | Tom Ehlert Software | Varmuuskopiointitiedostot | Drive Snapshot First Differential Backup | Tom Ehlert Drive Snapshot | Tom Ehlert Software |
| .SN2 | Tom Ehlert Software | Varmuuskopiointitiedostot | Drive Snapshot Second Differential Backup | Tom Ehlert Drive Snapshot | Tom Ehlert Software |
| .SN3 | Samsung Electronics | Varmuuskopiointitiedostot | Samsung Kies 2 Backup | Samsung Kies | Samsung Electronics |
| .SNA | Tom Ehlert Software | Varmuuskopiointitiedostot | Drive Snapshot Primary Backup File | Tom Ehlert Drive Snapshot | Tom Ehlert Software |
| .SNBKP | Samsung Electronics | Varmuuskopiointitiedostot | S Note Note Backup | S Note | Samsung Electronics |
| .SNS | FFmpeg team | Varmuuskopiointitiedostot | SNS Video Game Audio File | FFmpeg | FFmpeg team |
| .SNZ | Google | Varmuuskopiointitiedostot | Snappy SNZ Compressed File | Snappy | Google |
| .SPBA | Samsung Electronics | Varmuuskopiointitiedostot | Samsung Kies Contacts Backup | Samsung Kies | Samsung Electronics |
| .SPF | StorageCraft | Varmuuskopiointitiedostot | ShadowProtect Full Backup File | VMware vCenter Converter | VMware |
| .SPG | Speed Guide, Inc. | Varmuuskopiointitiedostot | TCP Optimizer Backup File | TCP Optimizer | Speed Guide, Inc. |
| .SPI | StorageCraft | Varmuuskopiointitiedostot | ShadowProtect Incremental Backup File | ShadowProtect | StorageCraft |
| .SPS | IBM | Varmuuskopiointitiedostot | SPSS Program File | IBM SPSS | IBM |
| .SQB | Redgate Software | Varmuuskopiointitiedostot | SQL Backup SQL Server Backup | SQL Backup | Redgate Software |
| .SRR | Open Source | Varmuuskopiointitiedostot | ReScene Metadata File | ReScene | Open Source |
| .SSB | Joshua Cannon Butcher | Varmuuskopiointitiedostot | Simply Safe Backup Archive | Simply Safe Backup | Joshua Cannon Butcher |
| .SSC | Microsoft Corporation | Varmuuskopiointitiedostot | SourceSafe Status File | Microsoft Visual Studio | Microsoft Corporation |
| .SSN | Samsung Electronics | Varmuuskopiointitiedostot | Samsung Kies Notes Backup | Samsung Kies | Samsung Electronics |
| .STG | Microsoft Corporation | Varmuuskopiointitiedostot | ActiveSync Backup File | Microsoft ActiveSync | Microsoft Corporation |
| .SUN | Sun Microsystems | Varmuuskopiointitiedostot | Sun Raster Graphic File | GIMP | The GIMP Development Team |
| .SV$ | Autodesk, Inc. | Varmuuskopiointitiedostot | AutoCAD Automated Backup File | Autodesk AutoCAD | Autodesk, Inc. |
| .SV2I | Symantec Corporation | Varmuuskopiointitiedostot | Symantec System Index File | VMware vCenter Converter | VMware |
| .SVL | SecurStar | Varmuuskopiointitiedostot | Scramdisk Volume | DriveCrypt | SecurStar |
| .SVS | Nintendo | Varmuuskopiointitiedostot | Game Boy Advance Saved State File | Game Boy Advance | Nintendo |
| .SY# | Unknown Developer | Varmuuskopiointitiedostot | Darn! Backup File | Unknown Software | Unknown Developer |
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