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| Extension | File Type Developer | File Category | File Type Description | Primary Software | Primary Software Developer |
|---|---|---|---|---|---|
| .SAVER | Apple | System Files | Mac OS X Screen Saver | Apple OS X | Apple |
| .SB | MIT Media Lab | System Files | Scratch Project File | MIT Scratch | MIT Media Lab |
| .SBF | System Files | Android System File | Google Android | ||
| .SBN | ESRI | System Files | ESRI Spatial Binary File | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SCF | Microsoft Corporation | System Files | Windows Explorer Command | Microsoft Windows | Microsoft Corporation |
| .SCHEMAS | Open Source | System Files | GConf Schema Definition File | GNU Emacs | GNU Project |
| .SCR | Microsoft Corporation | System Files | Windows Screensaver File | Microsoft Windows | Microsoft Corporation |
| .SCRIPT | Unknown Developer | System Files | Generic Script File | LibreOffice | The Document Foundation |
| .SDG | Golden Software LLC | System Files | Strater Project File | Strater | Golden Software LLC |
| .SDT | Intuit, Inc. | System Files | QuickBooks Data File | Intuit QuickBooks Pro | Intuit, Inc. |
| .SERVICE | Lennart Poettering and Kay Sievers | System Files | Systemd Service File | Linux | Open Source |
| .SF | Institut de Recherche et de Coordination Acoustique/Musique (IRCAM) | System Files | IRCAM Sound File | Awave Studio | FMJ-Software |
| .SF0 | Microsoft Corporation | System Files | Windows Sytem File Check File | Microsoft Windows | Microsoft Corporation |
| .SFCACHE | Microsoft Corporation | System Files | ReadyBoost Cache File | Microsoft Windows | Microsoft Corporation |
| .SFE | Unknown Developer | System Files | Logomatic V2 Firmware | Unknown Software | Unknown Developer |
| .SHA | Corel | System Files | CorelDraw Shader File | CorelDRAW Graphics Suite | Corel |
| .SHD | Microsoft Corporation | System Files | Windows Print Job Shadow File | Microsoft Windows | Microsoft Corporation |
| .SHS | Microsoft Corporation | System Files | Microsoft Scrap File | Microsoft Excel | Microsoft Corporation |
| .SID | Valve | System Files | Steam Game Data Backup File | Steam | Valve |
| .SIN | Big Huge Games | System Files | Rise Of Nations Campaign Media File | Rise Of Nations | Big Huge Games |
| .SL | SourceForge | System Files | Unix Software License File | Vi | SourceForge |
| .SPARC | Skype Technologies | System Files | Skype Plugin Archive | Skype | Skype Technologies |
| .SPL | Microsoft Corporation | System Files | Windows Print Spool File | Microsoft Windows | Microsoft Corporation |
| .SQM | Microsoft Corporation | System Files | Service Quality Monitoring File | Microsoft Windows | Microsoft Corporation |
| .SREC | Motorola | System Files | Motorola S-record Data | SRecord | Open Source |
| .STR | dBase, LLC | System Files | dBASE Structure List Object File | dBase | dBase, LLC |
| .STY | Jørgen Sørensen / Jososoft | System Files | Yamaha/Korg Keyboard Style | Style Fixer | Jørgen Sørensen / Jososoft |
| .SWAP | Microsoft Corporation | System Files | Swap File | Microsoft Windows | Microsoft Corporation |
| .SWP | Microsoft Corporation | System Files | Swap File | Microsoft Windows | Microsoft Corporation |
| .SYS | Microsoft Corporation | System Files | Windows System File | Microsoft Windows | Microsoft Corporation |
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