| .SBE | Safer Networking Ltd. | Settings Files | Spybot Exclude Data | Spybot - Search & Destroy | Safer Networking Ltd. |
| .SBS | Allegorithmic | Settings Files | Substance Package | Substance Designer | Allegorithmic |
| .SBV | Superbase Software | Settings Files | Superbase Form Definition File | Superbase | Papatuo Holdings Ltd |
| .SBX | Dream Design Entertainment Software | Settings Files | GLBasic Shoebox File | GLBasic | Dream Design Entertainment Software |
| .SCH | Autodesk, Inc. | Settings Files | EAGLE Schematics File | Autodesk EAGLE | Autodesk, Inc. |
| .SCHEMAS | Open Source | Settings Files | GConf Schema Definition File | GNU Emacs | GNU Project |
| .SDC | Stardock Corporation | Settings Files | Stardock Central Download Archive | Stardock Central | Stardock Corporation |
| .SDD | Programming Sunrise | Settings Files | Smart Diary Suite Data File | Smart Diary Suite | Programming Sunrise |
| .SDI | Intuit, Inc. | Settings Files | QuickBooks Data File | Intuit QuickBooks Pro | Intuit, Inc. |
| .SDM | Oracle Corporation | Settings Files | StarOffice Mail Message | StarOffice | Oracle Corporation |
| .SED | Microsoft Corporation | Settings Files | IExpress Self Extraction Directive File | Microsoft IExpress Wizard | Microsoft Corporation |
| .SEQU | Adobe Systems Incorporated | Settings Files | Adobe Acrobat Sequence File | Adobe Acrobat DC | Adobe Systems Incorporated |
| .SES | Adobe Systems Incorporated | Settings Files | Audition Session File | Adobe Audition | Adobe Systems Incorporated |
| .SET | Xerox | Settings Files | Document Library Property Set File | Xerox Library Administration Tool | Fuji Xerox |
| .SETTINGCONTENT-MS | Microsoft Corporation | Settings Files | Microsoft Windows 8.1 Configuration Data | Microsoft Windows 8 | Microsoft Corporation |
| .SETTINGS | Microsoft Corporation | Settings Files | Microsoft Visual Studio Settings File | Microsoft Visual Studio | Microsoft Corporation |
| .SFO | Interscape | Settings Files | PSP Game Parameters File | PBP Unpacker | Unknown Developer |
| .SFS | Open Source | Settings Files | Squashfs File Archive | 7-Zip | Igor Pavlov |
| .SG | Unknown Developer | Settings Files | SG-1000 Game ROM File | Kega Fusion | Steve Snake |
| .SGS | Open Source | Settings Files | WinDS PRO Data | WinDS PRO | Open Source |
| .SGT | IBM | Settings Files | SPSS Chart Template File | IBM SPSS | IBM |
| .SHADOW | Neuber Software | Settings Files | FontTwister Shadow File | FontTwister | Neuber Software |
| .SHH | Adobe Systems Incorporated | Settings Files | Adobe Photoshop Shadow/Highlight Settings | Adobe Photoshop CC | Adobe Systems Incorporated |
| .SIF | Microsoft Corporation | Settings Files | Windows Setup Information File | Microsoft Notepad | Microsoft Corporation |
| .SIZ | Oracle Corporation | Settings Files | Oracle 7 Configuration File | Oracle Database | Oracle Corporation |
| .SKI | Motorola | Settings Files | Motorola Phone Skin File | Apache OpenOffice | Apache Software Foundation |
| .SKIN | Microsoft Corporation | Settings Files | ASP.NET Skin File | Microsoft Visual Studio | Microsoft Corporation |
| .SKL | Autodesk, Inc. | Settings Files | Maya Skeleton File | Autodesk Maya | Autodesk, Inc. |
| .SKN | Avant Force | Settings Files | Avant Browser Skin File | Avant Browser | Avant Force |
| .SKP | Trimble Inc. | Settings Files | SketchUp Document | SketchUp | Trimble Inc. |
| .SKZ | SuperKaramba Project | Settings Files | SuperKaramba Theme | SuperKaramba | SuperKaramba Project |
| .SL | SourceForge | Settings Files | Unix Software License File | Vi | SourceForge |
| .SLT | Mozilla | Settings Files | Mozilla User Profile Folder | Mozilla Firefox | Mozilla |
| .SMR | Uberware | Settings Files | Smedge2 Job Settings File | Smedge2 | Uberware |
| .SMS | Sega | Settings Files | Sega Master System ROM | Kega Fusion | Steve Snake |
| .SMT | Intuit, Inc. | Settings Files | QuickBooks Data File | Intuit QuickBooks Pro | Intuit, Inc. |
| .SMX | MakeMusic, Inc. | Settings Files | SmartMusic XML File | SmartMusic | MakeMusic, Inc. |
| .SNC | Swiftpage, Inc. | Settings Files | ACT! E-mail/folder Synchronization File | Act! | Swiftpage, Inc. |
| .SNX | Pi Innovo | Settings Files | PISnoop Workspace File | PiSnoop | Pi Innovo |
| .SOC | Apache Software Foundation | Settings Files | OpenOffice.org Configuration File | Apache OpenOffice | Apache Software Foundation |
| .SOL | Adobe Systems Incorporated | Settings Files | Flash Local Shared Object File | Adobe Flash Player | Adobe Systems Incorporated |
| .SPF | StorageCraft | Settings Files | ShadowProtect Full Backup File | VMware vCenter Converter | VMware |
| .SPFX | Sorenson Media | Settings Files | Squeeze Presets File | Squeeze | Sorenson Media |
| .SPJ | IBM | Settings Files | SPSS Production Job File | IBM SPSS | IBM |
| .SPN | Corel | Settings Files | Corel WordPerfect Distribution Definition | Corel WordPerfect | Corel |
| .SPS | IBM | Settings Files | SPSS Program File | IBM SPSS | IBM |
| .SQD | SparkPath Technologies | Settings Files | Configuration Settings File | SP Debugger for SQR | SparkPath Technologies |
| .SRF | NewTek | Settings Files | LightWave Surface File | LightWave 3D | NewTek |
| .SRP | Check Point Software Technologies Ltd. | Settings Files | Checkpoint Exported VPN Client Information File | ZoneAlarm Pro | Check Point Software Technologies Ltd. |
| .SRS | Microsoft Corporation | Settings Files | Outlook Send/Receive Settings File | Microsoft Outlook | Microsoft Corporation |
| .SRV | FBB Software | Settings Files | FBB Initialization Settings | FBB Packet-Radio BBS | FBB Software |
| .SSB | Joshua Cannon Butcher | Settings Files | Simply Safe Backup Archive | Simply Safe Backup | Joshua Cannon Butcher |
| .SSL | Bethesda Softworks | Settings Files | Fallout Script | Fallout Script Editor | Jargo |
| .SSS | Stardock Corporation | Settings Files | WindowBlinds Substyle File | WindowBlinds | Stardock Corporation |
| .SSZ | Open Source | Settings Files | Spider Player Skin File | Spider Player Pro | Open Source |
| .STB | Autodesk, Inc. | Settings Files | AutoCAD Plot Style Table File | Autodesk AutoCAD | Autodesk, Inc. |
| .STC | Adobe Systems Incorporated | Settings Files | Contribute Connection Key File | Adobe Contribute 6.5 | Adobe Systems Incorporated |
| .STD | Oracle Corporation | Settings Files | Apache OpenOffice Drawing Template | Apache OpenOffice | Apache Software Foundation |
| .STE | Adobe Systems Incorporated | Settings Files | Dreamweaver Site Settings File | Microsoft Notepad | Microsoft Corporation |
| .STF | Microsoft Corporation | Settings Files | Exchange 2000 Server Temporary File | Microsoft Exchange Server | Microsoft Corporation |
| .STP | Unknown Developer | Settings Files | STEP 3D CAD File | CATIA | Dassault Systèmes |
| .STT | Microsoft Corporation | Settings Files | Streets & Trips Map Template | Microsoft AutoRoute | Microsoft Corporation |
| .STY | Jørgen Sørensen / Jososoft | Settings Files | Yamaha/Korg Keyboard Style | Style Fixer | Jørgen Sørensen / Jososoft |
| .STYLE | Trimble Inc. | Settings Files | SketchUp Style | SketchUp | Trimble Inc. |
| .SUBLIME-KEYMAP | Sublime HQ Pty Ltd | Settings Files | Sublime Text Keymap Data | Sublime Text | Sublime HQ Pty Ltd |
| .SUBLIME-PROJECT | Sublime HQ Pty Ltd | Settings Files | Sublime Text Project | Sublime Text | Sublime HQ Pty Ltd |
| .SUBLIME-SESSION | Sublime HQ Pty Ltd | Settings Files | Sublime Text Session Data | Sublime Text | Sublime HQ Pty Ltd |
| .SUBLIME-SETTINGS | Sublime HQ Pty Ltd | Settings Files | Sublime Text Settings | Sublime Text | Sublime HQ Pty Ltd |
| .SUBLIME-SNIPPET | Sublime HQ Pty Ltd | Settings Files | Sublime Text Snippet | Sublime Text | Sublime HQ Pty Ltd |
| .SUBLIME-SYNTAX | Sublime HQ Pty Ltd | Settings Files | Sublime Text Syntax Definition Format | Sublime Text | Sublime HQ Pty Ltd |
| .SUBLIME-WORKSPACE | Sublime HQ Pty Ltd | Settings Files | Sublime Text Workspace Settings | Sublime Text | Sublime HQ Pty Ltd |
| .SUITE | Stardock Corporation | Settings Files | Stardock WinStyles Suite | ZipZag | Open Source |
| .SVP | SwiftView, Inc. | Settings Files | SwiftView Command File | SwiftView | SwiftView, Inc. |
| .SVS | Nintendo | Settings Files | Game Boy Advance Saved State File | Game Boy Advance | Nintendo |
| .SWE | Electronic Arts | Settings Files | NHL Ice Hockey 2002 Required Data | NHL 2002 | Electronic Arts |
| .SZ | Nullsoft | Settings Files | Winamp Classic Skin Download | Nullsoft Winamp | Nullsoft |
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