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| Extension | File Type Developer | File Category | File Type Description | Primary Software | Primary Software Developer |
|---|---|---|---|---|---|
| .S1A | Oracle Corporation | Encoded Files | Sealed Acrobat Document | Unsealer | Oracle Corporation |
| .S1E | SealedMedia | Encoded Files | Sealed Excel Worksheet File | Unsealer | Oracle Corporation |
| .SAFE | Interscape | Encoded Files | SIGLock Encrypted Extension File | Sigza SIGLock | Sigza Systems |
| .SCB | Scala | Encoded Files | Scala Published Script | Scala Designer | Scala |
| .SDO | Signere.no | Encoded Files | Signed Document | Signere.no Document Viewer | Signere.no |
| .SDOC | Samsung Electronics | Encoded Files | Samsung Memo File | Samsung Kies | Samsung Electronics |
| .SEB | Franklin Electronic Publishers, Inc. | Encoded Files | Franklin eBookMan E-book | Unknown Software | Unknown Developer |
| .SEF | Steganos | Encoded Files | Password Manager Container File | Steganos Password Manager | Steganos |
| .SFI | SafeSuite | Encoded Files | SafeFolder Encrypted File | SafeFolder | SafeSuite |
| .SHY | Dr. Bootz | Encoded Files | ShyFile Encrypted File | Dr. Bootz ShyFile | Dr. Bootz |
| .SIGN | Free Software Foundation | Encoded Files | GNU Privacy Guard Data | GNU Privacy Guard | GNU Project |
| .SJP | Oracle Corporation | Encoded Files | Sealed JPG File | Oracle IRM Desktop | Oracle Corporation |
| .SJPG | Oracle Corporation | Encoded Files | Sealed JPG File | Oracle IRM Desktop | Oracle Corporation |
| .SLM | Morrison Software | Encoded Files | Gallery Lock Hidden Media | Gallery Lock Pro | Morrison Software |
| .SNK | Microsoft Corporation | Encoded Files | Strong Name Key File | Microsoft Visual Studio | Microsoft Corporation |
| .SPD | AutoDesSys, Inc. | Encoded Files | Form-Z Suspended Render Data | AutoDesSys formZ | AutoDesSys, Inc. |
| .SPDF | Oracle Corporation | Encoded Files | Sealed PDF File | Oracle IRM Desktop | Oracle Corporation |
| .SUF | SourceForge | Encoded Files | Ccrypt Encrypted File | ccrypt | SourceForge |
| .SWITCH | Egress Software Technologies | Encoded Files | Switch Package | Egress Switch | Egress Software Technologies |
| .SXL | SealedMedia | Encoded Files | Sealed Excel Worksheet File | Unsealer | Oracle Corporation |
| .SXML | Oracle Corporation | Encoded Files | Sealed XML File | Oracle IRM Desktop | Oracle Corporation |
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