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| Extension | File Type Developer | File Category | File Type Description | Primary Software | Primary Software Developer |
|---|---|---|---|---|---|
| .E2 | DPT Corp | CAD Files | Thinkdesign CAD Document | ThinkDesign Suite | DPT Corp |
| .E3 | DPT Corp | CAD Files | Think3 Thinkdesign CAD Document | ThinkDesign Suite | DPT Corp |
| .E3P | Zuken | CAD Files | E3.series Mechanical Part | E3.series | Zuken |
| .E3S | Zuken | CAD Files | E3.series Project | E3.series | Zuken |
| .EASM | Dassault Systèmes | CAD Files | eDrawings Assembly File | Dassault Systemes SolidWorks | Dassault Systèmes |
| .ECA | Unknown Developer | CAD Files | ElectroCAD File | Unknown Software | Unknown Developer |
| .ED | ANDOR Co, Ltd | CAD Files | EasyDraw CAD File | EasyDraw | ANDOR Co, Ltd |
| .EDF | ESRF | CAD Files | ESRF Data File | SAXS Program Package | ESRF |
| .EDN | Xilinx, Inc. | CAD Files | EDIF Implementation Netlist File | Xilinx ISE WebPACK | Xilinx, Inc. |
| .EDRW | Dassault Systèmes | CAD Files | SolidWorks eDrawings File | Dassault Systemes SolidWorks | Dassault Systèmes |
| .EDRWX | Dassault Systèmes | CAD Files | SolidWorks eDrawings XPS Drawing Document File | SOLIDWORKS | Dassault Systèmes |
| .ELD | DIAL | CAD Files | Eulumdat Formatted Luminaire Data File | DIAL DIALux | DIAL |
| .EMN | PTC | CAD Files | Pro/ENGINEER ECAD IDF File | Creo Parametric 3D Modeling Software | PTC |
| .EMV | National Instruments | CAD Files | LabVIEW Configuration File | LabVIEW | National Instruments |
| .ENR | EnRoute Software | CAD Files | EnRoute V2 Toolpath Data | EnRoute | EnRoute Software |
| .EPF | Vero Software | CAD Files | Edgecam Educational Part File | Planit Edgecam | Vero Software |
| .EPRT | Dassault Systèmes | CAD Files | eDrawings File | Dassault Systemes SolidWorks | Dassault Systèmes |
| .EPX | Informatix Inc. | CAD Files | Piranesi 3D Model File | Piranesi | Informatix Inc. |
| .EQN | Altium | CAD Files | GAL Equation File | Altium Designer | Altium |
| .EQX | Gabor Nagy | CAD Files | EQUINOX Project File | EQUINOX | Gabor Nagy |
| .ESJ | Thermwood Corporation | CAD Files | eCabinet CAD File | eCabinet Systems | Thermwood Corporation |
| .EST | Microsoft Corporation | CAD Files | Streets & Trips Map File | Microsoft MapPoint | Microsoft Corporation |
| .ETZ | Bentley Systems | CAD Files | RAM Elements Model | RAM Elements | Bentley Systems |
| .EWB | National Instruments | CAD Files | Electronics Workbench Circuit Design File | NI Multisim | National Instruments |
| .EWD | DDX Group | CAD Files | EasyWOOD Design File | EasyWOOD | DDX Group |
| .EXB | CAXA | CAD Files | CAXA Draft | IronCAD | IronCAD, LLC |
| .EXP | Unknown Developer | CAD Files | Symbols Export File | Microsoft Visual Studio | Microsoft Corporation |
| .EXPORT | Dassault Systèmes | CAD Files | CATIA Export Data | CATIA | Dassault Systèmes |
| .EZC | Autodesk, Inc. | CAD Files | AutoCAD Ecscad Components Backup File | Autodesk AutoCAD Ecscad | Autodesk, Inc. |
| .EZP | Autodesk, Inc. | CAD Files | AutoCAD Ecscad Project Backup File | Autodesk AutoCAD Ecscad | Autodesk, Inc. |
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