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| Extension | File Type Developer | File Category | File Type Description | Primary Software | Primary Software Developer |
|---|---|---|---|---|---|
| .U | Epic Games | Audio Files | Unreal Tournament Class Package | Dragon UnPACKer | Open Source |
| .U8 | Nintendo | Audio Files | Mario Kart Wii Archive File | Wiimms SZS Toolset | Nintendo |
| .UAX | Epic Games | Audio Files | Unreal Audio Package | Dragon UnPACKer | Open Source |
| .UB | Waveform Software | Audio Files | Unsigned Byte Audio File | Apple QuickTime Player | Apple |
| .UDW | FMJ-Software | Audio Files | Raw Unsigned DoubleWord (32-bit) Data | Awave Studio | FMJ-Software |
| .ULT | Radionomy | Audio Files | UltraTracker Module | CocoModX | Open Source |
| .ULW | NCH Software | Audio Files | U-Law Audio File | NCH Switch | NCH Software |
| .UNI | Open Source | Audio Files | MikMod UniMOD Module | CocoModX | Open Source |
| .USF | EVGA Corporation | Audio Files | EVGA Precision X Skin File | EVGA PrecisionX | EVGA Corporation |
| .USR | FileMaker Inc. | Audio Files | FileMaker Pro Database File | FileMaker Pro | FileMaker Inc. |
| .UST | UTAU Team | Audio Files | UTAU Sequence Text File | Vocal Synthesizer Tool UTAU | UTAU Team |
| .UVD | Yamaha Corporation | Audio Files | Yamaha Tyros4 Audio Data | Tyros4 | Yamaha Corporation |
| .UVN | Yamaha Corporation | Audio Files | Yamaha Tyros Audio | Awave Studio | FMJ-Software |
| .UW | Apple | Audio Files | Unsigned Word Audio File | Apple QuickTime Player | Apple |
| .UWF | Marc Andrй Schallehn | Audio Files | UltraTracker Wave File | CocoModX | Open Source |
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