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| Extension | File Type Developer | File Category | File Type Description | Primary Software | Primary Software Developer |
|---|---|---|---|---|---|
| .S1A | Oracle Corporation | Audio Files | Sealed Acrobat Document | Unsealer | Oracle Corporation |
| .S1M | Yamaha Corporation | Audio Files | Yamaha EX5 Waveform Data | Awave Studio | FMJ-Software |
| .S1Y | Yamaha Corporation | Audio Files | Yamaha EX-series Synthesizer Internal Voice And Performance Data | Unknown Software | Unknown Developer |
| .S3I | Open Source | Audio Files | Scream Tracker 3 Instrument | Scream Tracker 3 | Future Crew |
| .S3M | FMJ-Software | Audio Files | S3M | ModPlug Player | Open Source |
| .S3Z | Future Crew | Audio Files | Compressed Scream Tracker 3 Module | ModPlug Player | Open Source |
| .S48 | Jutel | Audio Files | Jutel RadioMan MPEG2 Audio | Jutel RadioMan | Jutel |
| .S7 | Avid Technology | Audio Files | Sibelius Music Notation | Avid Sibelius | Avid Technology |
| .SA2 | Nullsoft | Audio Files | Suprise! Adlib Tracker Music Module | Nullsoft Winamp | Nullsoft |
| .SAF | DeLorme | Audio Files | Street Atlas USA Map File | DeLorme Street Atlas USA | DeLorme |
| .SAG | Sagem Communication (SAFRAN Group) | Audio Files | Sagem Ringtone Format | Unknown Software | Unknown Developer |
| .SAP | Atari Corporation | Audio Files | Atari SAP Music File | Nullsoft Winamp | Nullsoft |
| .SB | MIT Media Lab | Audio Files | Scratch Project File | MIT Scratch | MIT Media Lab |
| .SBG | Open Source | Audio Files | SBaGen Binaural Beat File | SBaGen | Open Source |
| .SBI | Creative Technology Ltd. | Audio Files | Sound Blaster Instrument | Virtual Sound Blaster | Creative Technology Ltd. |
| .SBK | SwishZone | Audio Files | SWiSH Project Backup File | SWiSH Max | SwishZone |
| .SBM | Keen Software House | Audio Files | Space Engineers Mod File | Space Engineers | Keen Software House |
| .SC2 | EA Maxis | Audio Files | SimCity 2000 City File | Maxis SimCity 2000 | EA Maxis |
| .SD | Various Developers | Audio Files | Sound Designer Audio File | Awave Studio | FMJ-Software |
| .SD2 | Avid Technology | Audio Files | Sound Designer II File | Apple iTunes | Apple |
| .SD2F | Avid Technology | Audio Files | Sound Designer II File | Apple iTunes | Apple |
| .SDK | Autodesk, Inc. | Audio Files | AutoSketch Drawing | AutoSketch | Autodesk, Inc. |
| .SDP | Oracle Corporation | Audio Files | StarOffice Presentation File | Apache OpenOffice | Apache Software Foundation |
| .SDS | Oracle Corporation | Audio Files | OpenOffice.org Chart | Apache OpenOffice | Apache Software Foundation |
| .SDT | Intuit, Inc. | Audio Files | QuickBooks Data File | Intuit QuickBooks Pro | Intuit, Inc. |
| .SDV | Pinnacle Systems Inc. | Audio Files | Studio DV Project File | Pinnacle Studio | Corel |
| .SDX | Kivuto | Audio Files | Kivuto Secure Download Manager File | Kivuto Secure Download Manager | Kivuto |
| .SEG | SEG (The Society of Exploration Geophysicists) | Audio Files | SEG-2 Data File | Unknown Software | Unknown Developer |
| .SEQ | PG Music Inc | Audio Files | PowerTracks Pro Audio Project File | PowerTracks Pro Audio | PG Music Inc |
| .SES | Adobe Systems Incorporated | Audio Files | Audition Session File | Adobe Audition | Adobe Systems Incorporated |
| .SE_ | Cakewalk, Inc. | Audio Files | CakeWalk Pro Compressed Audio File | Cakewalk Pro | Cakewalk, Inc. |
| .SF | Institut de Recherche et de Coordination Acoustique/Musique (IRCAM) | Audio Files | IRCAM Sound File | Awave Studio | FMJ-Software |
| .SF2 | E-mu Systems | Audio Files | SoundFont 2 Sound Bank | Awave Studio | FMJ-Software |
| .SFAP0 | Magix Software GmbH | Audio Files | Sound Forge Pro Audio Proxy File | MAGIX Vegas | Magix Software GmbH |
| .SFK | Magix Software GmbH | Audio Files | Sound Forge Pro Audio Peak File | MAGIX Vegas | Magix Software GmbH |
| .SFL | Magix Software GmbH | Audio Files | Sound Forge Pro Sound Data File | MAGIX Vegas | Magix Software GmbH |
| .SFPACK | Megota Software | Audio Files | Packed SoundFont File | SFPack | Megota Software |
| .SFR | Sonic Foundry | Audio Files | Sonic Foundry Sample Resource File | Awave Studio | FMJ-Software |
| .SFS | Open Source | Audio Files | Squashfs File Archive | 7-Zip | Igor Pavlov |
| .SFZ | Cakewalk, Inc. | Audio Files | SFZ Format File | sforzando | Plogue Art et Technologie |
| .SGW | n-Track | Audio Files | n-Track Studio Packed Song | n-Track Studio | n-Track |
| .SHN | Tony Robinson | Audio Files | Shorten Compressed Audio File | Nullsoft Winamp | Nullsoft |
| .SIB | Avid Technology | Audio Files | Sibelius Score | Avid Sibelius | Avid Technology |
| .SID | Valve | Audio Files | Steam Game Data Backup File | Steam | Valve |
| .SIP | Chris S. Craig | Audio Files | ScopeTrax Compressed Sample File | ScopeTrax | Chris S. Craig |
| .SJ | Blue Ribbon SoundWorks | Audio Files | SuperJAM Audio File | SuperJAM | Blue Ribbon SoundWorks |
| .SLP | Magix Software GmbH | Audio Files | SpectraLayers Pro Project | SpectraLayers Pro | Magix Software GmbH |
| .SLX | MathWorks | Audio Files | MathWorks Simulink Model | Simulink | MathWorks |
| .SLY | GNU Project | Audio Files | Lilypond Guitar File | LilyPond | GNU Project |
| .SMA | Don Ho | Audio Files | C/C++ Source Code File | MacroMates TextMate | MacroMates |
| .SMF | Oracle Corporation | Audio Files | StarMath Formula File | Apache OpenOffice | Apache Software Foundation |
| .SMP | MakeMusic, Inc. | Audio Files | SmartMusic Performance File | SmartMusic | MakeMusic, Inc. |
| .SN | Bluemoon Interactive | Audio Files | Sound Club Editor Compressed Song | Sound Club | Bluemoon Interactive |
| .SN2 | Tom Ehlert Software | Audio Files | Drive Snapshot Second Differential Backup | Tom Ehlert Drive Snapshot | Tom Ehlert Software |
| .SNC | Swiftpage, Inc. | Audio Files | ACT! E-mail/folder Synchronization File | Act! | Swiftpage, Inc. |
| .SND | Open Source | Audio Files | Sound File | Microsoft Windows Media Player | Microsoft Corporation |
| .SNG | Korg | Audio Files | Korg Trinity Song File | Alchemist | SourceForge |
| .SNS | FFmpeg team | Audio Files | SNS Video Game Audio File | FFmpeg | FFmpeg team |
| .SON | Open Source | Audio Files | Notator SL Audio File | Apple Logic Pro | Apple |
| .SONG | Naive Solutions | Audio Files | AudioSauna Song File | Naive Solutions AudioSauna | Naive Solutions |
| .SONIC | Sonic Solutions | Audio Files | DigitalMedia Project File | Roxio Creator NXT Pro 5 | Roxio |
| .SOU | LucasArts Entertainment Company, LLC | Audio Files | Lucas Arts Sound Data | Dragon UnPACKer | Open Source |
| .SPH | National Institute of Standards and Technology (NIST) | Audio Files | NIST SPHERE Audio File | SoX | Open Source |
| .SPM | Corel | Audio Files | Corel WordPerfect Data | Corel WordPerfect | Corel |
| .SPS | IBM | Audio Files | SPSS Program File | IBM SPSS | IBM |
| .SPU | Atari Corporation | Audio Files | Spectrum 512 Image | Lemkesoft GraphicConverter | Lemkesoft |
| .SPX | Xiph.Org | Audio Files | Ogg Vorbis Speex File | Microsoft Windows Media Player | Microsoft Corporation |
| .SRI | Nuance | Audio Files | Dragon NaturallySpeaking Audio Data File | Dragon NaturallySpeaking | Nuance |
| .SS3 | Unknown Developer | Audio Files | Singer Song Writer Audio File | Unknown Software | Unknown Developer |
| .SSM | RealNetworks | Audio Files | Standard Streaming Metafile | RealPlayer | Realtime Technologies |
| .STI | Oracle Corporation | Audio Files | StarOffice Presentation Template | Apache OpenOffice | Apache Software Foundation |
| .STM | Microsoft Corporation | Audio Files | Exchange Streaming Media File | Microsoft Exchange Server | Microsoft Corporation |
| .STW | Oracle Corporation | Audio Files | StarOffice Document Template | Apache OpenOffice | Apache Software Foundation |
| .STX | Unknown Developer | Audio Files | Scream Tracker Music Interface Kit File | CocoModX | Open Source |
| .STY | Jørgen Sørensen / Jososoft | Audio Files | Yamaha/Korg Keyboard Style | Style Fixer | Jørgen Sørensen / Jososoft |
| .STZ | Future Crew | Audio Files | Screamtracker 2 Module | Scream Tracker 3 | Future Crew |
| .SUN | Sun Microsystems | Audio Files | Sun Raster Graphic File | GIMP | The GIMP Development Team |
| .SVD | Polytec | Audio Files | Scanning Vibrometer Data File | Polytec PSV Software | Polytec |
| .SVQ | Roland Corporation | Audio Files | Roland Sequencer File | Awave Studio | FMJ-Software |
| .SVX | The Survex Project | Audio Files | Survex Cavern Data File | Microsoft Notepad | Microsoft Corporation |
| .SW | Waveform Software | Audio Files | Signed Word Audio File | Waveform SoX Wrap | Waveform Software |
| .SWA | Adobe Systems Incorporated | Audio Files | Shockwave Audio | Adobe Director | Adobe Systems Incorporated |
| .SXT | FMJ-Software | Audio Files | Propellerheads Reason 2 NN-XT Sound Data | FMJ-Software Awave Audio | FMJ-Software |
| .SYN | Image-Line | Audio Files | SimSynth Document | FL Studio 12 | Image-Line |
| .SYW | Yamaha Corporation | Audio Files | Yamaha SY99/SY85 Audio File | Awave Studio | FMJ-Software |
| .SYX | Cakewalk, Inc. | Audio Files | MIDI System Exclusive Message | Cakewalk SONAR | Cakewalk, Inc. |
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