| .EARTHTIME | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .EATF | Apple | Data Files | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .EBC | SourceForge | Developer Files | MediaBASIC Compiled Project | Unknown Software | Unknown Developer |
| .EBV | ASH WARE | Data Files | Ash Ware Enhanced Behavior Data | Unknown Software | Unknown Developer |
| .EBX | IBM | Developer Files | Rational Rose 98 Compiled Script | Unknown Software | Unknown Developer |
| .EC | Informix Corporation | Developer Files | Informix ESQL/C Source | Unknown Software | Unknown Developer |
| .ECA | Unknown Developer | CAD Files | ElectroCAD File | Unknown Software | Unknown Developer |
| .ECC | Carsten Gnörlich | Data Files | Dvdisaster Error Correction File | Unknown Software | Unknown Developer |
| .ECELP4800 | Nuera Communications | Settings Files | Nuera ECELP Speech Codec Family | Unknown Software | Unknown Developer |
| .ECELP7470 | Nuera Communications | Audio Files | Nuera Audio File | Unknown Software | Unknown Developer |
| .ECELP9600 | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .ECLIPSEPRO | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .ECMA | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .ECW2002PUZ | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .ECW2002WOR | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .EFC | Unknown Developer | Data Files | EFCoins File | Unknown Software | Unknown Developer |
| .EGT | EagleGet | Uncommon Files | EagleGet Temporary File | Unknown Software | Unknown Developer |
| .EIF | Envex Solutions | Data Files | Envex Import Format File | Unknown Software | Unknown Developer |
| .EIZ | EIAS3D | Graphic Files | Electric Image File Format | Unknown Software | Unknown Developer |
| .EKA | Borland | Data Files | Eureka Internal Data File | Unknown Software | Unknown Developer |
| .EKY | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .ELN | Blackboard Collaborate | Data Files | Blackboard Collaborate Note Document | Unknown Software | Unknown Developer |
| .EMJSX | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .EMK | Elex Media | Backup Files | EMK Compress Archive | Unknown Software | Unknown Developer |
| .EMQ | Unknown Developer | Uncommon Files | Uncommon File Extension | Unknown Software | Unknown Developer |
| .EMQZ | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .EMS | Intergraph Corporation | Data Files | Intergraph Engineering Modelling System File | Unknown Software | Unknown Developer |
| .EMZJ | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .EOS | Unknown Developer | Uncommon Files | Uncommon File Extension | Unknown Software | Unknown Developer |
| .EP3 | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .EPV | Unknown Developer | Uncommon Files | Uncommon File Extension | Unknown Software | Unknown Developer |
| .ER2 | Apple | Data Files | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .ERIC | Apple | Data Files | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .EST2015 | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .ETA | Google | GIS Files | Google Earth Placemark File | Unknown Software | Unknown Developer |
| .ETM | Etreppid Technologies, LLC | Audio Files | eTreppid Audio File | Unknown Software | Unknown Developer |
| .ETW | Enter Tech | Audio Files | Enter Tech Recorded Audio | Unknown Software | Unknown Developer |
| .EV6 | Unknown Developer | Uncommon Files | EV8 Virtual Reality Applications File | Unknown Software | Unknown Developer |
| .EVA | Unknown Developer | Graphic Files | Viz Modeler 3D Scene Archive File | Unknown Software | Unknown Developer |
| .EWZ | Qivx, Inc. | Compressed Files | EdgeWize Compressed Encoded Data File | Unknown Software | Unknown Developer |
| .EXEMPLE | Apple | Data Files | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .EXPLOSION | Apple | Data Files | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .EYA | ESRI China (Beijing) | Graphic Files | eYaViewer Graphics File | Unknown Software | Unknown Developer |
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