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| Extension | File Type Developer | File Category | File Type Description | Software | Software Developer |
|---|---|---|---|---|---|
| .SREC | Motorola | System Files | Motorola S-record Data | SRecord | Open Source |
| .SRR | Open Source | Backup Files | ReScene Metadata File | ReScene | Open Source |
| .SRT | SourceForge | Video Files | SubRip Subtitle File | Gaupol Subtitle Editor | Open Source |
| .SS | Open Source | Developer Files | SilverStripe Source Code File | SilverStripe | Open Source |
| .SSA | Open Source | Text Files | Sub Station Alpha Subtitle File | VirtualDub | Open Source |
| .SSC | Microsoft Corporation | Developer Files | SourceSafe Status File | Celestia | Open Source |
| .SSM | RealNetworks | Video Files | Standard Streaming Metafile | SSMEx | Open Source |
| .SSP | Scala | Web Files | Scala Server Page | Scalate | Open Source |
| .SST | Microsoft Corporation | Uncommon Files | Serialized Certificate Store File | Embroidermodder 2 | Open Source |
| .SSZ | Open Source | Settings Files | Spider Player Skin File | Spider Player Pro | Open Source |
| .STA | Dassault Systèmes | Data Files | ABAQUS Status File | MAME | Open Source |
| .STATS | Open Source | Data Files | FreeSurfer Statistics File | FreeSurfer | Open Source |
| .STATUS | Open Source | Data Files | UDraw(Graph) File | UDraw(Graph) | Open Source |
| .STC | Adobe Systems Incorporated | Web Files | Contribute Connection Key File | Celestia | Open Source |
| .STE | Adobe Systems Incorporated | Settings Files | Dreamweaver Site Settings File | Notepad2 | Open Source |
| .STEP | Unknown Developer | 3D Image Files | STEP 3D Model | FreeCAD | Open Source |
| .STG | Microsoft Corporation | Backup Files | ActiveSync Backup File | Visual Pinball | Open Source |
| .STL | 3D Systems | CAD Files | Stereolithography File | MeshLab | Open Source |
| .STM | Microsoft Corporation | Data Files | Exchange Streaming Media File | CocoModX | Open Source |
| .STP | Unknown Developer | 3D Image Files | STEP 3D CAD File | FreeCAD | Open Source |
| .STR | dBase, LLC | Data Files | dBASE Structure List Object File | PSMplay | Open Source |
| .STX | Unknown Developer | Audio Files | Scream Tracker Music Interface Kit File | CocoModX | Open Source |
| .STY | Jørgen Sørensen / Jososoft | Audio Files | Yamaha/Korg Keyboard Style | TEXnicCenter | Open Source |
| .SUB | URUWORKS | Text Files | Subtitle File | Universal Subtitle Viewer | Open Source |
| .SUITE | Stardock Corporation | Settings Files | Stardock WinStyles Suite | ZipZag | Open Source |
| .SUJ | Open Source | Data Files | Stacker Unlimited Job | Stacker Unlimited | Open Source |
| .SUN | Sun Microsystems | Raster Image Files | Sun Raster Graphic File | IrfanView | Open Source |
| .SUP | Unknown Developer | Raster Image Files | Subtitle Bitmap File | IfoEdit | Open Source |
| .SV6 | Chris Sawyer | Game Files | RollerCoaster Tycoon 2 Saved Game | OpenRCT2 | Open Source |
| .SV7 | Nintendo | Game Files | Saved Game File | DeSmuME | Open Source |
| .SVG | Nintendo | Game Files | Saved Game File | DeSmuME | Open Source |
| .SVH | IEEE Xplore | Developer Files | SystemVerilog Source Code Header File | Notepad2 | Open Source |
| .SVS | Nintendo | Game Files | Game Boy Advance Saved State File | XWE | Open Source |
| .SVT | Runic Games | Game Files | Torchlight Saved Game File | TorchTools | Open Source |
| .SWF | Adobe Systems Incorporated | Video Files | Shockwave Flash Movie | Media Player Classic | Open Source |
| .SWM | Microsoft Corporation | Disk Image Files | Split Windows Imaging Format File | ExtractNow | Open Source |
| .SWP | Microsoft Corporation | System Files | Swap File | gVim | Open Source |
| .SXT | FMJ-Software | Audio Files | Propellerheads Reason 2 NN-XT Sound Data | Dragon UnPACKer | Open Source |
| .SYM | The Eclipse Foundation | Developer Files | Symbols File | GDB | Open Source |
| .SYSTEM | Open Source | Game Files | Vega Strike Virtual System File | gVim | Open Source |
| .SZX | Open Source | Data Files | Spectaculator ZX-State Snapshot | Spectaculator | Open Source |
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