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| Extension | File Type Developer | File Category | File Type Description | Software | Software Developer |
|---|---|---|---|---|---|
| .S | Unknown Developer | Developer Files | Source Code File | gVim | Open Source |
| .S07 | Eugene Roshal | Compressed Files | Split Multi-volume RAR Compressed File | PeaZip | Open Source |
| .S09 | Eugene Roshal | Compressed Files | Split Multi-volume RAR Compressed File | PeaZip | Open Source |
| .S1 | Open Source | Uncommon Files | Free Pascal File | Free Pascal | Open Source |
| .S3M | FMJ-Software | Audio Files | S3M | ModPlug Player | Open Source |
| .S3Z | Future Crew | Audio Files | Compressed Scream Tracker 3 Module | ModPlug Player | Open Source |
| .S7Z | Igor Pavlov | Compressed Files | 7-Zip Compressed File | PeaZip | Open Source |
| .SA1 | VBA Team | Game Files | Game Boy Emulator Save File | TGB Dual | Open Source |
| .SAD | LucasArts Entertainment Company, LLC | Game Files | Lucas Arts Sound Data | Dragon UnPACKer | Open Source |
| .SAL | Oracle Corporation | Developer Files | SQL Application Language Source Code | SORITEC | Open Source |
| .SAM | Microsoft Corporation | Text Files | LMHOSTS Sample File | CocoModX | Open Source |
| .SAP | Atari Corporation | Audio Files | Atari SAP Music File | Cog | Open Source |
| .SAV | Nintendo | Game Files | Saved Game File | DeSmuME | Open Source |
| .SAVE | Unknown Developer | Text Files | Nano Temporary Save File | GNU nano | Open Source |
| .SAX | Open Source | Developer Files | Sedona Framework XML Application | Sedona Framework | Open Source |
| .SB | MIT Media Lab | Developer Files | Scratch Project File | Slax | Open Source |
| .SB2 | MIT Media Lab | Developer Files | Scratch 2.0 Project File | Snap! | Open Source |
| .SBG | Open Source | Audio Files | SBaGen Binaural Beat File | SBaGen | Open Source |
| .SBP | Autodesk, Inc. | Raster Image Files | Sketchbook Express iCloud Image | GPSBabel | Open Source |
| .SBV | Superbase Software | Page Layout Files | Superbase Form Definition File | PSPad | Open Source |
| .SCA | Symantec Corporation | Data Files | Norton AntiVirus Scan File | Notepad2 | Open Source |
| .SCE | Open Source | Data Files | Scilab Script | Scilab | Open Source |
| .SCHEMAS | Open Source | System Files | GConf Schema Definition File | AbiWord | Open Source |
| .SCI | Open Source | Data Files | Scilab Script | Scilab | Open Source |
| .SCM | Gimpel Software | Plugin Files | GIMP Script-Fu Script | Sanny Builder | Open Source |
| .SCN | Microsoft Corporation | Game Files | Age Of Mythology Scenario File | OpenTTD | Open Source |
| .SCR | Microsoft Corporation | System Files | Windows Screensaver File | Notepad2 | Open Source |
| .SCRIPT | Unknown Developer | Executable Files | Generic Script File | AbiWord | Open Source |
| .SD7 | Unknown Developer | Game Files | Spring RTS Engine Data File | Spring | Open Source |
| .SDF | Microsoft Corporation | Database Files | SQL Server Compact Database File | Avogadro | Open Source |
| .SDT | Intuit, Inc. | Data Files | QuickBooks Data File | Dragon UnPACKer | Open Source |
| .SDW | LizardTech | GIS Files | MrSID World File | GDAL | Open Source |
| .SEED | Open Source | Executable Files | Linux Preseed File | Ubuntu | Open Source |
| .SERVICE | Lennart Poettering and Kay Sievers | System Files | Systemd Service File | Linux | Open Source |
| .SETTINGS | Microsoft Corporation | Settings Files | Microsoft Visual Studio Settings File | Bukkit | Open Source |
| .SEV | Open Source | Disk Image Files | SevenUp Picture | ZX-Paintbrush | Open Source |
| .SF | Institut de Recherche et de Coordination Acoustique/Musique (IRCAM) | Audio Files | IRCAM Sound File | SFPrime | Open Source |
| .SFB | Sony | Game Files | PlayStation 3 Disc Data File | PSPad | Open Source |
| .SFC | Unknown Developer | Game Files | Super Nintendo ROM | higan | Open Source |
| .SFD | Open Source | Video Files | Sofdec Dreamcast Movie | Media Player Classic | Open Source |
| .SFF | Elecbyte | Game Files | M.U.G.E.N. Sprite File | IrfanView | Open Source |
| .SFL | Magix Software GmbH | Audio Files | Sound Forge Pro Sound Data File | SFPrime | Open Source |
| .SFP | Troy | Font Files | Soft Font Printer File | SFPrime | Open Source |
| .SFS | Open Source | Compressed Files | Squashfs File Archive | PeaZip | Open Source |
| .SG | Unknown Developer | Game Files | SG-1000 Game ROM File | OpenEmu | Open Source |
| .SG1 | Open Source | 3D Image Files | Standford Graphics File | WinDS PRO | Open Source |
| .SGA | Relic Entertainment | Game Files | Relic Entertainment Game Archive | Corsix's Mod Studio | Open Source |
| .SGML | Corel | Data Files | Standard Generalized Markup Language File | epicEdit | Open Source |
| .SGN | Signet Bureau | 3D Image Files | Signet Bureau DRM File | Slax | Open Source |
| .SGR | Electronic Arts | Game Files | SimCity 4 Graphics Rules File | Integrated Genome Browser | Open Source |
| .SGS | Open Source | Settings Files | WinDS PRO Data | WinDS PRO | Open Source |
| .SGY | Open Source | Data Files | SEG-Y Seismic Data File | Segpy | Open Source |
| .SH | Unknown Developer | Developer Files | Bash Shell Script | gVim | Open Source |
| .SHN | Tony Robinson | Audio Files | Shorten Compressed Audio File | Cog | Open Source |
| .SHR | Open Source | Compressed Files | Unix Shell Archive File | unshar | Open Source |
| .SHTML | Sublime HQ Pty Ltd | Web Files | Server Side Include HTML File | NetBeans | Open Source |
| .SID | Valve | Game Files | Steam Game Data Backup File | ACID 64 Player | Open Source |
| .SIF | Microsoft Corporation | Settings Files | Windows Setup Information File | Notepad2 | Open Source |
| .SIN | Big Huge Games | Game Files | Rise Of Nations Campaign Media File | Dragon UnPACKer | Open Source |
| .SIT | Smith Micro Software | Compressed Files | StuffIt Archive | ExtractNow | Open Source |
| .SKCHR | Open Source | CAD Files | SketchChair Design | SketchChair | Open Source |
| .SKETCH | Bohemian Coding | Vector Image Files | Sketch Drawing | Photopea | Open Source |
| .SKI | Motorola | Settings Files | Motorola Phone Skin File | AbiWord | Open Source |
| .SLA | Open Source | Text Files | Scribus Document | Scribus | Open Source |
| .SLC | Open Source | CAD Files | SLiCe Format Data | 3D Object Converter | Open Source |
| .SLS | Sublime HQ Pty Ltd | Uncommon Files | Image Playlist | PSPad | Open Source |
| .SLT | Mozilla | Settings Files | Mozilla User Profile Folder | K-Meleon | Open Source |
| .SM | Open Source | Game Files | StepMania Song File | StepMania | Open Source |
| .SMA | Don Ho | Developer Files | C/C++ Source Code File | gVim | Open Source |
| .SMD | Valve | 3D Image Files | Valve Studiomdl Data File | Gens Plus! | Open Source |
| .SMI | Apple | Disk Image Files | Self-Mounting Disk Image | Ambulant Player | Open Source |
| .SMIL | "Synchronized Multimedia" Working Group (SYMM WG) | Video Files | SMIL(Synchronized Multimedia Integration Language) Presentation File | Ambulant Player | Open Source |
| .SML | ESRI | Developer Files | ARC/INFO Simple Macro Language File | Ambulant Player | Open Source |
| .SMP | MakeMusic, Inc. | Audio Files | SmartMusic Performance File | GDAL | Open Source |
| .SMS | Sega | Game Files | Sega Master System ROM | MESS | Open Source |
| .SMZ | Open Source | Data Files | SMath Studio Compressed Document | SMath Studio | Open Source |
| .SMZIP | Open Source | Game Files | StepMania Package | StepMania | Open Source |
| .SNAP | Erik Kunze | Data Files | ZX Spectrum Emulator Mirage Microdrive Snapshot | Ubuntu | Open Source |
| .SNB | Samsung Electronics | Compressed Files | S Note File (Old Version) | Calibre | Open Source |
| .SOK | Open Source | Game Files | Sokoban++ Level File | Sokoban | Open Source |
| .SOL | Adobe Systems Incorporated | Settings Files | Flash Local Shared Object File | SolVE: Local Shared Object Viewer/Editor | Open Source |
| .SON | Open Source | Audio Files | Notator SL Audio File | Notator SL | Open Source |
| .SOS | 3AM Solutions | CAD Files | Dynamite VSP Swept Object Style File | sosi2other | Open Source |
| .SOU | LucasArts Entertainment Company, LLC | Game Files | Lucas Arts Sound Data | Dragon UnPACKer | Open Source |
| .SOUNDS | id Software | Game Files | Quake 3 Engine Sound Definition File | AbiWord | Open Source |
| .SPC | Various Developers | Web Files | Software Publisher Certificate File | OpenSSL | Open Source |
| .SPEC | Open Source | Developer Files | RPM Specification File | rpmbuild | Open Source |
| .SPH | National Institute of Standards and Technology (NIST) | Audio Files | NIST SPHERE Audio File | SoX | Open Source |
| .SPLIT | Incredible Bee Ltd | Uncommon Files | Archiver Split File | PeaZip | Open Source |
| .SPM | Corel | Data Files | Corel WordPerfect Data | RPM Package Manager | Open Source |
| .SPN | Corel | Settings Files | Corel WordPerfect Distribution Definition | PSPad | Open Source |
| .SPRITE | MIT Media Lab | Raster Image Files | Scratch Sprite File | Snap! | Open Source |
| .SPS | IBM | Data Files | SPSS Program File | Mymc | Open Source |
| .SPX | Xiph.Org | Audio Files | Ogg Vorbis Speex File | XMMS | Open Source |
| .SQLITEDB | Dwayne Richard Hipp | Database Files | SQLite Database | SQLite Database Browser | Open Source |
| .SQML | Open Source | Developer Files | Standard Query Markup Language Document | SQML | Open Source |
| .SQUASHFS | Open Source | Data Files | Squashfs File System File | Squashfs | Open Source |
| .SR | Sun Microsystems | Raster Image Files | Sun Raster Image File | IrfanView | Open Source |
| .SRB | Open Source | Data Files | XWE File | XWE | Open Source |
| .SRC | Unknown Developer | Developer Files | Source Code File | gVim | Open Source |
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