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| Extension | File Type Developer | File Category | File Type Description | Software | Software Developer |
|---|---|---|---|---|---|
| .M3U | Nullsoft | Audio Files | Media Playlist File | Clementine | Open Source |
| .M3U8 | Various Developers | Audio Files | UTF-8 M3U Playlist File | CocoModX | Open Source |
| .M4 | Open Source | Developer Files | Macro Processor Library | AbiWord | Open Source |
| .M4A | Apple | Audio Files | MPEG-4 Audio File | Eltima Elmedia Player | Open Source |
| .M4S | Ubisoft | Game Files | Myst IV: Revelation Save Game File | MP4Box | Open Source |
| .M4V | Apple | Video Files | iTunes Video File | Eltima Elmedia Player | Open Source |
| .M75 | Moving Picture Experts Group | Video Files | MPEG Video File | CocoModX | Open Source |
| .MA2 | Blizzard Entertainment Inc. | Game Files | Diablo II Map File | BibExcel | Open Source |
| .MAB | Mozilla | Uncommon Files | Mozilla Address Book | Markaby | Open Source |
| .MAD | Electronic Arts | Game Files | Electronic Arts Madcow Movie File | Media Player Classic | Open Source |
| .MAF | National Cancer Institute | Data Files | Mutation Annotation Format File | AbiWord | Open Source |
| .MAG | Microsoft Corporation | Uncommon Files | Access Diagram Shortcut File | Magic VLSI | Open Source |
| .MAL | Open Source | Settings Files | MadAppLauncher Configuration File | MadAppLauncher | Open Source |
| .MAN | Unknown Developer | Text Files | Unix Manual | Pico | Open Source |
| .MAP | id Software | Game Files | Quake Engine Map File | Leges Motus | Open Source |
| .MARKDOWN | Various Developers | Developer Files | Markdown Documentation File | gVim | Open Source |
| .MBZ | Unknown Developer | Plugin Files | Pogoshell NES Emulator Plugin | Moodle | Open Source |
| .MCA | Mojang | Game Files | Minecraft "Anvil" Map File | NBTExplorer | Open Source |
| .MCR | Mojang | Game Files | Minecraft Region File | NBTExplorer | Open Source |
| .MD | Various Developers | Developer Files | Markdown Documentation File | gVim | Open Source |
| .MD3 | id Software | Game Files | Quake 3 3D Model | Cube 2 Sauerbraten | Open Source |
| .MD5 | Ron Rivest | Uncommon Files | MD5 Checksum File | RapidCRC | Open Source |
| .MDL | MathWorks | Data Files | MathWorks Simulink Model | ModPlug Player | Open Source |
| .MDR | Olivier Lapicque | Audio Files | ModPlug Compressed Module | ModPlug Player | Open Source |
| .MDV | Open Source | Disk Image Files | QLAY MDV Image | QLAY | Open Source |
| .MDX | Disc Soft Ltd. | Disk Image Files | Extended Media Descriptor File | MDXplay | Open Source |
| .ME | Unknown Developer | Uncommon Files | Temporary Delete Me File | Pico | Open Source |
| .MEA | Malvern Instruments Ltd | Data Files | Mastersizer 2000 Sample Analysis Data | Meazure | Open Source |
| .MED | Rockwell Automation Inc. | Developer Files | RSView Development Project Archive | PSPad | Open Source |
| .MEDLINE | National Library of Medicine | Data Files | MEDLINE Document | PSPad | Open Source |
| .MEM | Microsoft Corporation | Backup Files | FoxPro Variable File | GreekToMe | Open Source |
| .MET | Emulex Corporation | Data Files | eMule Resource File | eMule | Open Source |
| .MFD | Yamaha Corporation | Database Files | Music Finder Database | ABC Programming langauge | Open Source |
| .MFS | Open Source | Encoded Files | MetFS Encrypted File System | MetFS | Open Source |
| .MGA | Open Source | Page Layout Files | Manga Document | Manga Reader | Open Source |
| .MGP | Adobe Systems Incorporated | Data Files | Adobe Captivate MenuBuilder Data | Magic Point | Open Source |
| .MHA | Open Source | Graphic Files | MetaImage Medical Format | Insight Segmentation and Registration Toolkit | Open Source |
| .MHP | Open Source | Data Files | Maths Helper Plus File | Maths Helper Plus | Open Source |
| .MHX | Fujitsu Limited | Data Files | Fujitsu MicroController Firmware | MakeHuman | Open Source |
| .MI4 | NVIDIA | System Files | Audio Player Firmware File | Rockbox Utility | Open Source |
| .MID | Open Source | Audio Files | MIDI Audio File | TiMiDity++ | Open Source |
| .MIDI | Synthesia LLC | Audio Files | MIDI File | Audacity | Open Source |
| .MIF | Adobe Systems Incorporated | Page Layout Files | FrameMaker Interchange Format File | mAirList | Open Source |
| .MIN | Okuma | CAD Files | Okuma CNC Program File | Freemacs | Open Source |
| .MINGW | Open Source | Developer Files | MinGW Make File | MinGW | Open Source |
| .MINIPSF | Un4seen Developments | Audio Files | Miniature PlayStation Sound Format File | XMMS | Open Source |
| .MINT | Open Source | Compressed Files | Linux Mint Installer File | Linux Mint | Open Source |
| .MIO | Open Source | Executable Files | MioEngine Application File | MioFactory | Open Source |
| .MKA | Matroska | Audio Files | Matroska Audio File | Media Player Classic | Open Source |
| .MKD | Malz++Kassner | CAD Files | CAD 6 Drawing File | Daring Fireball Markdown | Open Source |
| .MKR | Microsoft Corporation | Game Files | Train Simulator Marker File | my Knowledge Explorer | Open Source |
| .MKS | Matroska | Data Files | Matroska Elementary Stream File | The Core Media Player | Open Source |
| .MKV | Various Developers | Video Files | Matroska Video File | Eltima Elmedia Player | Open Source |
| .ML | Robin Milner | Developer Files | ML Source Code File | gVim | Open Source |
| .MLC | Microsoft Corporation | System Files | Microsoft Language Interface Pack | mAirList | Open Source |
| .MLD | FMJ-Software | Audio Files | I-Melody Format For I-Mode | mAirList | Open Source |
| .MLP | Meridian Audio | Audio Files | Meridian Lossless Packing Audio File | mAirList | Open Source |
| .MLS | KIDASA Software, Inc. | Data Files | Milestones Simplicity File | mAirList | Open Source |
| .MMA | Open Source | Data Files | Master Album Maker Photo Album File | Master Album Maker Viewer | Open Source |
| .MMP | MixMeister Technology | Audio Files | MixMeister Studio Playlist | LMMS | Open Source |
| .MMV | Sony | Video Files | MicroMV Video File | Squared 5 MPEG Streamclip | Open Source |
| .MND | Autodesk, Inc. | Developer Files | AutoCAD Menu Compiler File | Fractal Forge | Open Source |
| .MNG | Various Developers | Raster Image Files | Multiple Network Graphic | IrfanView | Open Source |
| .MO | Dassault Systèmes | Data Files | Dymola Simulation File | Pidgin | Open Source |
| .MO3 | Un4seen Developments | Audio Files | MO3 Audio File | XMMS | Open Source |
| .MOBI | Amazon | eBook Files | Mobipocket eBook Format | Calibre | Open Source |
| .MOD | Open Source | Audio Files | Amiga Music Module File | ModPlug Player | Open Source |
| .MODULE | Open Source | Plugin Files | Drupal Module File | Notepad2 | Open Source |
| .MOFF | Sony | Video Files | Sony Video Data File | GPSBabel | Open Source |
| .MOGG | Unknown Developer | Audio Files | Multitrack Ogg File | Audacity | Open Source |
| .MOL | Interscape | Data Files | MDL Molfile | Avogadro | Open Source |
| .MOOD | Open Source | Data Files | Amarok Moodbar Data File | Amarok | Open Source |
| .MOOV | Apple | Video Files | Apple QuickTime Movie | Eltima Elmedia Player | Open Source |
| .MOT | NewTek | 3D Image Files | LightWave Motion File | Linux | Open Source |
| .MOV | Apple | Video Files | Apple QuickTime Movie | Eltima Elmedia Player | Open Source |
| .MP | Autodesk, Inc. | 3D Image Files | Maya PLE Project File | Texmaker | Open Source |
| .MP1 | RealNetworks | Audio Files | MPEG-1 Layer 1 Audio File | The Core Media Player | Open Source |
| .MP2V | Roxio | Video Files | MPEG-2 Video File | Media Player Classic | Open Source |
| .MP3 | Moving Picture Experts Group | Audio Files | MP3 Audio File | Eltima Elmedia Player | Open Source |
| .MP4 | Moving Picture Experts Group | Video Files | MPEG-4 Video File | Eltima Elmedia Player | Open Source |
| .MP41 | Microsoft Corporation | Video Files | Microsoft MP41 Video Data | FFDShow | Open Source |
| .MP4V | Moving Picture Experts Group | Video Files | MPEG-4 Video File | Eltima Elmedia Player | Open Source |
| .MPC | Open Source | Audio Files | Musepack Compressed Audio File | DeliPlayer | Open Source |
| .MPCPL | Open Source | Uncommon Files | Media Player Classic Playlist | Media Player Classic | Open Source |
| .MPE | Unknown Developer | Video Files | MPEG Movie | Eltima Elmedia Player | Open Source |
| .MPEG | Unknown Developer | Video Files | MPEG Movie | Eltima Elmedia Player | Open Source |
| .MPG | Moving Picture Experts Group | Video Files | MPEG Video File | CocoModX | Open Source |
| .MPG4 | Moving Picture Experts Group | Video Files | MPEG-4 Video File | Eltima Elmedia Player | Open Source |
| .MPGA | RealNetworks | Audio Files | MPEG-1 Layer 3 Audio File | XMMS | Open Source |
| .MPI | Open Source | Data Files | InstallJammer Project File | InstallJammer | Open Source |
| .MPK | ESRI | GIS Files | ArcGIS Map Package | Project64 | Open Source |
| .MPKG | Open Source | Compressed Files | Meta Package File | Linux | Open Source |
| .MPL | Sony | Video Files | AVCHD Playlist File | Media Player Classic | Open Source |
| .MPQ | Blizzard Entertainment Inc. | Game Files | Blizzard Mo'PaQ File | MPQ Editor | Open Source |
| .MPR | Open Source | Data Files | Bibexcel Data | BibExcel | Open Source |
| .MPS | IBM | Data Files | Mathematical Programming System File | Gnumeric | Open Source |
| .MPV | Moving Picture Experts Group | Video Files | MPEG Elementary Stream Video File | Eltima Elmedia Player | Open Source |
| .MPZ | Benetech | Data Files | Miradi Project File | Red Eclipse | Open Source |
| .MP_ | Open Source | Audio Files | Mobile Phone Sound File | BitPim | Open Source |
| .MQD | Open Source | Data Files | Malete Query Data File | Malete | Open Source |
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