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| Extension | File Type Developer | File Category | File Type Description | Software | Software Developer |
|---|---|---|---|---|---|
| .MPL | Sony | Video Files | AVCHD Playlist File | Media Player Classic | Open Source |
| .MPQ | Blizzard Entertainment Inc. | Game Files | Blizzard Mo'PaQ File | MPQ Editor | Open Source |
| .MPR | Open Source | Data Files | Bibexcel Data | BibExcel | Open Source |
| .MPS | IBM | Data Files | Mathematical Programming System File | Gnumeric | Open Source |
| .MPV | Moving Picture Experts Group | Video Files | MPEG Elementary Stream Video File | Eltima Elmedia Player | Open Source |
| .MPZ | Benetech | Data Files | Miradi Project File | Red Eclipse | Open Source |
| .MP_ | Open Source | Audio Files | Mobile Phone Sound File | BitPim | Open Source |
| .MQD | Open Source | Data Files | Malete Query Data File | Malete | Open Source |
| .MRD | Interscape | Text Files | MathRevolt Infinity Document | Malete | Open Source |
| .MRF | Apple | Font Files | Macintosh Font File | WinMorph | Open Source |
| .MRI | Open Source | Data Files | Pittsburgh MRI File Format | PGH_MRI | Open Source |
| .MRX | Open Source | Data Files | Record Access File | Malete | Open Source |
| .MS1 | VirtualBus.info | Game Files | VirtualBus Map File | VirtualBus | Open Source |
| .MSC | Microsoft Corporation | Uncommon Files | Microsoft C Makefile | MuseScore | Open Source |
| .MSCR | Kaleida Ltd | Developer Files | ServiceMon Script | Rename Master | Open Source |
| .MSCZ | Open Source | Audio Files | MuseScore Compressed Score File | MuseScore | Open Source |
| .MSH1XML | Microsoft Corporation | Settings Files | Monad Display Configuration File | AbiWord | Open Source |
| .MSL | Microsoft Corporation | Developer Files | Mapping Specification Language File | gVim | Open Source |
| .MT2 | Yannick Delwiche | Audio Files | MadTracker 2 Module | Schism Tracker | Open Source |
| .MTL | TurboCAD | 3D Image Files | OBJ Material File | MeshLab | Open Source |
| .MTM | VideoLAN | Audio Files | MultiTracker Module | ModPlug Player | Open Source |
| .MTS | Sony | Video Files | AVCHD Video File | Eltima Elmedia Player | Open Source |
| .MUSICXML | Michael Good | Audio Files | Compressed MusicXML File | MuseScore | Open Source |
| .MUZ | HoverDesk.net | Audio Files | MUZ Audio File | Audacity | Open Source |
| .MW | Apple | Text Files | MacWrite Text Document | MediaWiki | Open Source |
| .MXL | Michael Good | Audio Files | Compressed MusicXML File | MuseScore | Open Source |
| .MXML | Adobe Systems Incorporated | Developer Files | Flex MXML Component | gVim | Open Source |
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