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| Extension | File Type Developer | File Category | File Type Description | Software | Software Developer |
|---|---|---|---|---|---|
| .SB | MIT Media Lab | Developer Files | Scratch Project File | Apple QuickTime Player | Apple |
| .SD2 | Avid Technology | Audio Files | Sound Designer II File | Apple QuickTime Player | Apple |
| .SD2F | Avid Technology | Audio Files | Sound Designer II File | Apple QuickTime Player | Apple |
| .SDP | Oracle Corporation | Data Files | StarOffice Presentation File | Apple QuickTime Player | Apple |
| .SDS | Oracle Corporation | Data Files | OpenOffice.org Chart | Apple QuickTime Player | Apple |
| .SDX | Kivuto | Uncommon Files | Kivuto Secure Download Manager File | Apple QuickTime Player | Apple |
| .SMF | Oracle Corporation | Text Files | StarMath Formula File | Apple QuickTime Player | Apple |
| .SMI | Apple | Disk Image Files | Self-Mounting Disk Image | Apple QuickTime Player | Apple |
| .SMIL | "Synchronized Multimedia" Working Group (SYMM WG) | Video Files | SMIL(Synchronized Multimedia Integration Language) Presentation File | Apple QuickTime Player | Apple |
| .SML | ESRI | Developer Files | ARC/INFO Simple Macro Language File | Apple QuickTime Player | Apple |
| .SND | Open Source | Audio Files | Sound File | Apple QuickTime Player | Apple |
| .SNG | Korg | Audio Files | Korg Trinity Song File | Apple QuickTime Player | Apple |
| .SPX | Xiph.Org | Audio Files | Ogg Vorbis Speex File | Apple QuickTime Player | Apple |
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