| .QLC | Adobe Systems Incorporated | Data Files | Adobe PostScript Help File | Adobe Creative Suite | Adobe Systems Incorporated |
| .QT | Apple | Video Files | Apple QuickTime Movie | Adobe Flash Player | Adobe Systems Incorporated |
| .QTI | Apple | Raster Image Files | QuickTime Image File | Adobe Flash Professional CC | Adobe Systems Incorporated |
| .QTIF | Apple | Raster Image Files | QuickTime Image File | Adobe Flash Professional CC | Adobe Systems Incorporated |
| .QTM | Apple | Video Files | Apple QuickTime Movie | Adobe Flash Player | Adobe Systems Incorporated |
| .QXD | Quark Software Inc. | Page Layout Files | QuarkXPress Document | Adobe InDesign | Adobe Systems Incorporated |
| .QXT | Quark Software Inc. | Page Layout Files | QuarkXPress Template | Adobe InDesign | Adobe Systems Incorporated |
| .R3D | Various Developers | Video Files | REDCODE Video File | Adobe Premiere Pro CC | Adobe Systems Incorporated |
| .RAF | Fuji Xerox | Camera Raw Files | Fuji RAW Image File | Adobe Photoshop Elements | Adobe Systems Incorporated |
| .RAW | Unknown Developer | Camera Raw Files | Raw Image Data File | Adobe Photoshop Elements | Adobe Systems Incorporated |
| .RDT | Adobe Systems Incorporated | Data Files | Adobe Captivate RoboDemo Template File | Adobe Captivate | Adobe Systems Incorporated |
| .RF | Adobe Systems Incorporated | Data Files | Adobe FrameMaker Document | Adobe FrameMaker | Adobe Systems Incorporated |
| .RFR | Adobe Systems Incorporated | Data Files | Adobe Photoshop Frame Filter | Adobe Photoshop | Adobe Systems Incorporated |
| .RL4 | Various Developers | Raster Image Files | Bitmap Image File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .RL8 | Microsoft Corporation | Graphic Files | Windows Bitmap Image | Adobe Photoshop | Adobe Systems Incorporated |
| .RLE | Various Developers | Raster Image Files | Run Length Encoded Bitmap | Adobe Photoshop Elements | Adobe Systems Incorporated |
| .RMD | Thomson Reuters Corporation | Data Files | Reference Manager Data File | Adobe Premiere Pro CC | Adobe Systems Incorporated |
| .RMF | Valve | Game Files | Hammer Rich Map Format | Adobe Acrobat DC | Adobe Systems Incorporated |
| .RPF | Rockstar Games | Game Files | Grand Theft Auto Data File | Adobe After Effects | Adobe Systems Incorporated |
| .RPLN | Adobe Systems Incorporated | Plugin Files | InDesign Required Plug-in File | Adobe InDesign | Adobe Systems Incorporated |
| .RSA | Various Developers | Uncommon Files | RSA Certificate File | Adobe Photoshop Elements | Adobe Systems Incorporated |
| .RTA | Adobe Systems Incorporated | Data Files | RoboHelp RTA Data File | Adobe RoboHelp | Adobe Systems Incorporated |
| .RTK | Adobe Systems Incorporated | Data Files | Adobe RoboHelp Configuration File | Adobe RoboHelp | Adobe Systems Incorporated |
| .RVL | muvee | Video Files | Muvee Reveal X Project File | Adobe Revel | Adobe Systems Incorporated |
| .RWL | Leica Biosystems | Camera Raw Files | Leica D-Lux 4 RAW Image | Adobe Photoshop | Adobe Systems Incorporated |
| .SAT | Spatial Corp | CAD Files | ACIS SAT 3D Model File | Adobe Acrobat DC | Adobe Systems Incorporated |
| .SBL | Adobe Systems Incorporated | Graphic Files | Shockwave Flash Object | Adobe Flash Player | Adobe Systems Incorporated |
| .SBX | Dream Design Entertainment Software | Compressed Files | GLBasic Shoebox File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .SCM | Gimpel Software | Plugin Files | GIMP Script-Fu Script | ExtendScript Toolkit (ESTK) | Adobe Systems Incorporated |
| .SCSS | Sublime HQ Pty Ltd | Web Files | Syntactically Awesome Stylesheets Syntax Data | Adobe Dreamweaver | Adobe Systems Incorporated |
| .SCT | Scitex | Raster Image Files | Scitex Continuous Tone File | Adobe Photoshop | Adobe Systems Incorporated |
| .SD0 | Adobe Systems Incorporated | Camera Raw Files | Dali Raw Image | Adobe Lightroom CC | Adobe Systems Incorporated |
| .SD1 | Adobe Systems Incorporated | Camera Raw Files | Dali Raw Image | Adobe Lightroom CC | Adobe Systems Incorporated |
| .SEQU | Adobe Systems Incorporated | Settings Files | Adobe Acrobat Sequence File | Adobe Acrobat DC | Adobe Systems Incorporated |
| .SES | Adobe Systems Incorporated | Audio Files | Audition Session File | Adobe Audition | Adobe Systems Incorporated |
| .SESSION | Dassault Systèmes | 3D Image Files | CATIA 4 Session File | Adobe Acrobat DC | Adobe Systems Incorporated |
| .SGM | VBA Team | Game Files | VisualBoyAdvance Saved Game | Adobe FrameMaker | Adobe Systems Incorporated |
| .SGML | Corel | Data Files | Standard Generalized Markup Language File | Adobe FrameMaker | Adobe Systems Incorporated |
| .SHC | Adobe Systems Incorporated | Data Files | Adobe Photoshop Contours File | Adobe Photoshop CC | Adobe Systems Incorporated |
| .SHH | Adobe Systems Incorporated | Settings Files | Adobe Photoshop Shadow/Highlight Settings | Adobe Photoshop CC | Adobe Systems Incorporated |
| .SHTM | Opera Software | Video Files | HTML Server Side Include File | Adobe Dreamweaver | Adobe Systems Incorporated |
| .SHTML | Sublime HQ Pty Ltd | Web Files | Server Side Include HTML File | Adobe Dreamweaver | Adobe Systems Incorporated |
| .SITE | Adobe Systems Incorporated | Web Files | GoLive Website Project File | Adobe GoLive | Adobe Systems Incorporated |
| .SIV | Adobe Systems Incorporated | Video Files | Silicon Imaging Video File | Adobe SpeedGrade | Adobe Systems Incorporated |
| .SKL | Autodesk, Inc. | 3D Image Files | Maya Skeleton File | Adobe Authorware | Adobe Systems Incorporated |
| .SLDASM | Dassault Systèmes | CAD Files | SolidWorks Assembly File | Adobe Acrobat DC | Adobe Systems Incorporated |
| .SLDPRT | Dassault Systèmes | CAD Files | SolidWorks CAD Part File | Adobe Acrobat DC | Adobe Systems Incorporated |
| .SMP | MakeMusic, Inc. | Audio Files | SmartMusic Performance File | Adobe Audition | Adobe Systems Incorporated |
| .SND | Open Source | Audio Files | Sound File | Adobe Audition | Adobe Systems Incorporated |
| .SOL | Adobe Systems Incorporated | Settings Files | Flash Local Shared Object File | Adobe Flash Player | Adobe Systems Incorporated |
| .SOR | Adobe Systems Incorporated | Data Files | Adobe Flash Media Server File System Object | Adobe Media Server | Adobe Systems Incorporated |
| .SPL | Microsoft Corporation | System Files | Windows Print Spool File | Adobe Flash Player | Adobe Systems Incorporated |
| .SR2 | Sony | Camera Raw Files | Sony RAW Image | Adobe Photoshop | Adobe Systems Incorporated |
| .SRF | NewTek | 3D Image Files | LightWave Surface File | Adobe Photoshop | Adobe Systems Incorporated |
| .SRW | Samsung Electronics | Camera Raw Files | Samsung RAW Image | Adobe Photoshop Elements | Adobe Systems Incorporated |
| .SSI | Adobe Systems Incorporated | Developer Files | Adobe Dreamweaver Server Side Include File | Adobe Dreamweaver | Adobe Systems Incorporated |
| .SSK | Adobe Systems Incorporated | Vector Image Files | SmartSketch 95 Document | Adobe Flash Professional CC | Adobe Systems Incorporated |
| .STC | Adobe Systems Incorporated | Web Files | Contribute Connection Key File | Adobe Contribute 6.5 | Adobe Systems Incorporated |
| .STD | Oracle Corporation | Vector Image Files | Apache OpenOffice Drawing Template | Adobe Acrobat DC | Adobe Systems Incorporated |
| .STE | Adobe Systems Incorporated | Settings Files | Dreamweaver Site Settings File | Adobe Dreamweaver | Adobe Systems Incorporated |
| .STL | 3D Systems | CAD Files | Stereolithography File | Adobe Fireworks | Adobe Systems Incorporated |
| .STM | Microsoft Corporation | Data Files | Exchange Streaming Media File | Adobe Dreamweaver | Adobe Systems Incorporated |
| .STN | ON1, Inc. | Vector Image Files | Genuine Fractals Image | Adobe Photoshop | Adobe Systems Incorporated |
| .STP | Unknown Developer | 3D Image Files | STEP 3D CAD File | Adobe RoboHelp | Adobe Systems Incorporated |
| .SVG | Nintendo | Game Files | Saved Game File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .SVGZ | Adobe Systems Incorporated | Vector Image Files | Compressed SVG File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .SWA | Adobe Systems Incorporated | Audio Files | Shockwave Audio | Adobe Director | Adobe Systems Incorporated |
| .SWB | Adobe Systems Incorporated | Data Files | Adobe Photoshop Data | Adobe Photoshop | Adobe Systems Incorporated |
| .SWC | Adobe Systems Incorporated | Developer Files | Flex Components Archive | Adobe Animate CC 2017 | Adobe Systems Incorporated |
| .SWD | Adobe Systems Incorporated | Developer Files | Flash Debug File | Adobe Flash Player | Adobe Systems Incorporated |
| .SWF | Adobe Systems Incorporated | Video Files | Shockwave Flash Movie | Adobe Animate CC 2017 | Adobe Systems Incorporated |
| .SWL | Macromedia | Graphic Files | Alternate Macromedia Flash Format | Adobe Flash Player | Adobe Systems Incorporated |
| .SWT | Adobe Systems Incorporated | Video Files | Flash Generator Template | Adobe Flash Professional CC | Adobe Systems Incorporated |
| .SWZ | Adobe Systems Incorporated | Web Files | Adobe Flash Player Cache File | Adobe Flash Player | Adobe Systems Incorporated |
| .SYN | Image-Line | Audio Files | SimSynth Document | Adobe RoboHelp | Adobe Systems Incorporated |
| .T3D | Epic Games | 3D Image Files | Unreal Engine 3D Object File | Adobe Flash Player | Adobe Systems Incorporated |
| .TAL | Adobe Systems Incorporated | Text Files | Adobe TypeAlign Text Illustration File | Adobe TypeAlign | Adobe Systems Incorporated |
| .TBL | Blizzard Entertainment Inc. | Data Files | StarCraft Information Table | Adobe PageMaker | Adobe Systems Incorporated |
| .TBR | Adobe Systems Incorporated | Settings Files | Adobe Photoshop Custom Toolbar Preset | Adobe Photoshop | Adobe Systems Incorporated |
| .TCL | Open Source | Developer Files | Tcl Script | ExtendScript Toolkit (ESTK) | Adobe Systems Incorporated |
| .TGA | Avid Technology | Raster Image Files | Targa Graphic | Adobe Illustrator CC | Adobe Systems Incorporated |
| .THM | Sony | Uncommon Files | Sony Ericsson Mobile Phone Theme File | Adobe Photoshop Elements | Adobe Systems Incorporated |
| .TIF | XnSoft | Raster Image Files | Tagged Image File Format | Adobe Illustrator CC | Adobe Systems Incorporated |
| .TIFF | XnSoft | Raster Image Files | Tagged Image File Format | Adobe Illustrator CC | Adobe Systems Incorporated |
| .TIM | Sierra Entertainment | Game Files | The Incredible Machine Level | Adobe Illustrator CC | Adobe Systems Incorporated |
| .TOD | JVCKenwood Group | Video Files | JVC Everio Video Capture File | Adobe Flash Player | Adobe Systems Incorporated |
| .TPL | Unknown Developer | Text Files | Document Template | Adobe Photoshop | Adobe Systems Incorporated |
| .TTY | Adobe Systems Incorporated | Data Files | Adobe Dreamweaver Data | Adobe Dreamweaver | Adobe Systems Incorporated |
| .U3D | 3D Industry Forum | 3D Image Files | Universal 3D File | Adobe Acrobat DC | Adobe Systems Incorporated |
| .VB | Microsoft Corporation | Developer Files | Visual Basic Project Item File | Adobe Dreamweaver | Adobe Systems Incorporated |
| .VBS | Microsoft Corporation | Executable Files | VBScript File | Adobe Dreamweaver | Adobe Systems Incorporated |
| .VCE | Avanset | Data Files | Visual CertExam Suite Exam File | Adobe Audition | Adobe Systems Incorporated |
| .VDA | Microsoft Corporation | Raster Image Files | Targa Bitmap Image File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .VMC | Microsoft Corporation | Settings Files | Windows Virtual Machine Configuration File | Adobe Acrobat DC | Adobe Systems Incorporated |
| .VOC | Creative Technology Ltd. | Audio Files | Creative Labs Audio File | Adobe Audition | Adobe Systems Incorporated |
| .VOX | Ken Silverman | 3D Image Files | Voxlap Voxel Model File | Adobe Audition | Adobe Systems Incorporated |
| .VPH | optikVerve Labs | Settings Files | VirtualPhotographer Custom Settings | Adobe Photoshop | Adobe Systems Incorporated |
| .VPR | Adobe Systems Incorporated | Data Files | Adobe Premiere Preset | Adobe Premiere Pro CC | Adobe Systems Incorporated |
| .VST | Microsoft Corporation | Raster Image Files | Targa Bitmap Image File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .VTM | Adobe Systems Incorporated | Developer Files | Visual Tool Markup Language Document | Adobe Dreamweaver | Adobe Systems Incorporated |
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