| .M15 | Moving Picture Experts Group | Video Files | MPEG Video File | Adobe Flash Player | Adobe Systems Incorporated |
| .M1V | Roxio | Video Files | MPEG-1 Video File | Adobe Flash Professional CC | Adobe Systems Incorporated |
| .M2T | Roxio | Video Files | HDV Video File | Adobe Premiere Pro CC | Adobe Systems Incorporated |
| .M2TS | Sony | Video Files | Blu-ray BDAV Video File | Adobe Flash Player | Adobe Systems Incorporated |
| .M75 | Moving Picture Experts Group | Video Files | MPEG Video File | Adobe Flash Player | Adobe Systems Incorporated |
| .MASK | Adobe Systems Incorporated | Settings Files | SpeedGrade Color Mask File | Adobe SpeedGrade | Adobe Systems Incorporated |
| .MAX | Autodesk, Inc. | 3D Image Files | 3ds Max Scene File | Adobe Acrobat DC | Adobe Systems Incorporated |
| .MD0 | Alcohol Soft | Disk Image Files | Alcohol Disk Image Segment 1 | Adobe Photoshop CC | Adobe Systems Incorporated |
| .MEF | Microsoft Corporation | Camera Raw Files | Mamiya RAW Image | Adobe Photoshop Elements | Adobe Systems Incorporated |
| .MF2 | Adobe Systems Incorporated | Video Files | Authorware Mediator5 Multimedia File | Adobe Authorware | Adobe Systems Incorporated |
| .MFD | Yamaha Corporation | Database Files | Music Finder Database | Adobe Creative Suite | Adobe Systems Incorporated |
| .MFW | MamiyaLeaf | Camera Raw Files | Mamiya Camera Raw File | Adobe Photoshop CC | Adobe Systems Incorporated |
| .MGP | Adobe Systems Incorporated | Data Files | Adobe Captivate MenuBuilder Data | Adobe Captivate | Adobe Systems Incorporated |
| .MHTM | Microsoft Corporation | Web Files | Mime HTML (MHTML) File | Adobe Dreamweaver | Adobe Systems Incorporated |
| .MHTML | Microsoft Corporation | Web Files | Mime HTML (MHTML) File | Adobe Dreamweaver | Adobe Systems Incorporated |
| .MIF | Adobe Systems Incorporated | Page Layout Files | FrameMaker Interchange Format File | Adobe FrameMaker | Adobe Systems Incorporated |
| .MJ2 | Open Source | Video Files | Motion JPEG 2000 Video | Adobe Premiere Pro CC | Adobe Systems Incorporated |
| .MJD | Adobe Systems Incorporated | Encoded Files | Adobe Acrobat MIME Encoded Job Definition File | Adobe Acrobat DC | Adobe Systems Incorporated |
| .MJP2 | Open Source | Video Files | Motion JPEG 2000 Video | Adobe Premiere Pro CC | Adobe Systems Incorporated |
| .MML | Adobe Systems Incorporated | Page Layout Files | FrameMaker Maker Markup Language File | Adobe FrameMaker | Adobe Systems Incorporated |
| .MNO | Adobe Systems Incorporated | Data Files | Macromedia Design Note | Adobe Dreamweaver | Adobe Systems Incorporated |
| .MNU | Autodesk, Inc. | Settings Files | AutoCAD Interface Layout File | Adobe Photoshop CC | Adobe Systems Incorporated |
| .MOCHA | Adobe Systems Incorporated | Graphic Files | Adobe Mocha For Adobe After Effects File | Adobe After Effects | Adobe Systems Incorporated |
| .MOOV | Apple | Video Files | Apple QuickTime Movie | Adobe Flash Player | Adobe Systems Incorporated |
| .MOS | MamiyaLeaf | Camera Raw Files | Leaf Camera RAW File | Adobe Photoshop CC | Adobe Systems Incorporated |
| .MOV | Apple | Video Files | Apple QuickTime Movie | Adobe Flash Player | Adobe Systems Incorporated |
| .MP2 | New World Computing | Game Files | Heroes Of Might And Magic II Map File | Adobe Audition | Adobe Systems Incorporated |
| .MP3 | Moving Picture Experts Group | Audio Files | MP3 Audio File | Adobe Audition | Adobe Systems Incorporated |
| .MPG | Moving Picture Experts Group | Video Files | MPEG Video File | Adobe Flash Player | Adobe Systems Incorporated |
| .MPJ | Minitab Inc | Data Files | Minitab Project File | Adobe RoboHelp | Adobe Systems Incorporated |
| .MPO | CyberLink | Raster Image Files | CIPA Multi Picture Object File | Adobe Photoshop | Adobe Systems Incorporated |
| .MRW | Konica Minolta | Camera Raw Files | Minolta Raw Image File | Adobe Photoshop Elements | Adobe Systems Incorporated |
| .MSH | Martin Schweiger | 3D Image Files | Orbiter 3D Mesh File | Visual Communicator | Adobe Systems Incorporated |
| .MTL | TurboCAD | 3D Image Files | OBJ Material File | Adobe Photoshop CC | Adobe Systems Incorporated |
| .MUSE | Adobe Systems Incorporated | Web Files | Adobe Muse Website Project | Adobe Muse CC | Adobe Systems Incorporated |
| .MXF | SMPTE | Video Files | Material Exchange Format File | Adobe Premiere Pro CC | Adobe Systems Incorporated |
| .MXI | Adobe Systems Incorporated | Data Files | Adobe Extension Information File | Adobe InCopy | Adobe Systems Incorporated |
| .MXML | Adobe Systems Incorporated | Developer Files | Flex MXML Component | Adobe Flash Builder | Adobe Systems Incorporated |
| .MXP | Adobe Systems Incorporated | Plugin Files | Adobe Extension Package | Adobe Extension Manager CC | Adobe Systems Incorporated |
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