| .BWW | Doug Wickstrom | Audiodateien | Bagpipe Player File | Bagpipe Player | Doug Wickstrom |
| .C01 | e-merge GmbH | Audiodateien | WinAce Split Archive Part 1 File | WinAce | e-merge GmbH |
| .CA3 | Casio Computer Co., Ltd. | Audiodateien | Casio WK-1800 Save All Data | WK-1800 | Casio Computer Co., Ltd. |
| .CAF | Apple | Audiodateien | Apple Core Audio File | Apple QuickTime Player | Apple |
| .CAFF | Apple | Audiodateien | Core Audio File | Apple QuickTime Player | Apple |
| .CAP | Microsoft Corporation | Audiodateien | Network Monitor Packet Capture Data File | Microsoft Network Monitor | Microsoft Corporation |
| .CC_ | Unknown Developer | Audiodateien | Audio Utility Midimach Compressed File | Unknown Software | Unknown Developer |
| .CD | Microsoft Corporation | Audiodateien | Visual Studio Class Diagram | Microsoft Visual Studio | Microsoft Corporation |
| .CDA | Microsoft Corporation | Audiodateien | CD Audio Track Shortcut | Microsoft Windows Media Player | Microsoft Corporation |
| .CDDA | Microsoft Corporation | Audiodateien | CD Digital Audio File | Apple iTunes | Apple |
| .CDG | Open Source | Audiodateien | Compact Disc Plus Graphics Image | Nullsoft Winamp | Nullsoft |
| .CDO | NCH Software | Audiodateien | Crescendo Music Notation File | NCH Crescendo Music Notation Editor | NCH Software |
| .CDR | Corel | Audiodateien | CorelDRAW Vector Image File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .CEL | Affymetrix | Audiodateien | Affymetrix Probe Results File | The MathWorks MATLAB | MathWorks |
| .CF1 | Würth Online World GmbH | Audiodateien | WOW! Data | WOW! | Würth Online World GmbH |
| .CFA | Frontline | Audiodateien | ComProbe Analyzer Capture File | Frontline ComProbe Analysis System | Frontline |
| .CKB | Cricket Technology | Audiodateien | Cricket Audio Bank File | Cricket audio | Cricket Technology |
| .CKF | Casio Computer Co., Ltd. | Audiodateien | Casio Keyboard File | Casio Data Manager | Casio Computer Co., Ltd. |
| .CL3 | Roxio | Audiodateien | Easy CD Creator CD Layout | Roxio Creator NXT Pro 5 | Roxio |
| .CMF | Creative Technology Ltd. | Audiodateien | Creative Music Format | Nullsoft Winamp | Nullsoft |
| .CMP | Microsoft Corporation | Audiodateien | Windows Connection Manager Profile | Microsoft Windows Server 2016 | Microsoft Corporation |
| .COPY | Sony Mobile Communications | Audiodateien | Sony Ericsson Protected Content File | Sony Ericsson Mobile Phones | Sony Mobile Communications |
| .CPR | Steinberg | Audiodateien | Cubase Project | Steinberg Cubase | Steinberg |
| .CPT | Corel | Audiodateien | Corel Photo-Paint Image | Corel Presentations X8 | Corel |
| .CS3 | Casio Computer Co., Ltd. | Audiodateien | Casio WK-1800 Keyboard Output File | WK-1800 | Casio Computer Co., Ltd. |
| .CSH | Adobe Systems Incorporated | Audiodateien | Photoshop Custom Shapes File | Adobe Photoshop Elements | Adobe Systems Incorporated |
| .CTS | Reallusion, Inc. | Audiodateien | CrazyTalk Script File | CrazyTalk | Reallusion, Inc. |
| .CWP | Cakewalk, Inc. | Audiodateien | Cakewalk SONAR Project | Cakewalk SONAR | Cakewalk, Inc. |
| .CWS | ChordWizard Software Pty Ltd | Audiodateien | ChordWizard Songtrix Song | ChordWizard Songtrix | ChordWizard Software Pty Ltd |
| .D01 | Yamaha Corporation | Audiodateien | OPL2 FM Audio File | Winamp with Ganbatte! Plug-in | Unknown Developer |
| .DAB | Epigon Media Technologies | Audiodateien | Digital Audio Broadcasting Audio Data | DMB Player | Epigon Media Technologies |
| .DAW | Hasbro | Audiodateien | Hasbro Scrabble CDROM OWL2 List File | Hasbro Scrabble CD-ROM | Hasbro |
| .DB | Dwayne Richard Hipp | Audiodateien | Mobile Device Database File | SQLite | Dwayne Richard Hipp |
| .DCF | Sony Mobile Communications | Audiodateien | DRM Content Format File | DRM Packager | Sony Mobile Communications |
| .DCM | National Electrical Manufacturers Association (NEMA) | Audiodateien | DICOM Image File Format | Adobe Photoshop | Adobe Systems Incorporated |
| .DCT | Microsoft Corporation | Audiodateien | Dictionary File | QuarkXPress | Quark Software Inc. |
| .DDA | MicroImages | Audiodateien | TNTmips Import File Format | TNTmips | MicroImages |
| .DDT | Sports Interactive | Audiodateien | Football Manager Keep Player Data File | Football Manager 2016 | Sports Interactive |
| .DEWF | Macromedia | Audiodateien | SoundEdit Recorded Instrument | Awave Studio | FMJ-Software |
| .DF2 | Jenner Fusari | Audiodateien | Defractor 2 Instrument | Neurotix Defractor | Jenner Fusari |
| .DFC | Jenner Fusari | Audiodateien | Defractor Instrument | Neurotix Defractor | Jenner Fusari |
| .DFF | Zanoza Software | Audiodateien | RenderWare Model File | Zanoza ZModeler | Zanoza Software |
| .DFM | Open Source | Audiodateien | Pascal File | Notepad++ | Don Ho |
| .DFU | Apple | Audiodateien | iOS DFU File | Apple iOS | Apple |
| .DHP | Media Cybernetics | Audiodateien | Dr. Halo II-III Bitmap File | Dr. Halo III paint program | Media Cybernetics |
| .DIG | Various Developers | Audiodateien | Sound Designer Audio File | Awave Studio | FMJ-Software |
| .DJE | Unknown Developer | Audiodateien | MattBatt iAM-player Track List | Unknown Software | Unknown Developer |
| .DJR | Avanquest Software | Audiodateien | Ringtone Media Studio DJ Ringtone Project | Avanquest Ringtone Media Suite | Avanquest Software |
| .DKD | Interscape | Audiodateien | Karaoke Music File | JBK Karaoke Player | Interscape |
| .DLP | Microsoft Corporation | Audiodateien | DirectMusic Producer DLS Data | DirectMusic Producer | Neowin |
| .DLS | Not a Hat / Pete Yandell | Audiodateien | Downloadable Sounds File | SimpleSynth | Not a Hat / Pete Yandell |
| .DMC | nModal Solutions Inc. | Audiodateien | Datamartist Data Canvas File | nModal Solutions Datamartist | nModal Solutions Inc. |
| .DMF | Geosystem | Audiodateien | Geosystem Digitals Map File | Geosystem Digitals | Geosystem |
| .DRA | Nuance | Audiodateien | Dragon NaturallySpeaking Voice | Dragon NaturallySpeaking | Nuance |
| .DRO | Open Source | Audiodateien | DOSBox Raw OPL Format | DOSBox | Open Source |
| .DRX | Adobe Systems Incorporated | Audiodateien | Adobe Photoshop Tutorial Data | Adobe Photoshop | Adobe Systems Incorporated |
| .DS | DAZ 3D | Audiodateien | DAZ Studio 1/2 Script | DAZ Studio | DAZ 3D |
| .DSF | DAZ 3D | Audiodateien | DAZ Studio Asset File | DAZ Studio | DAZ 3D |
| .DSM | Open Source | Audiodateien | Digital Sound Module | ModPlug Player | Open Source |
| .DSP | Open Source | Audiodateien | Dynamic Studio Professional Module | ModPlug Player | Open Source |
| .DSS | The International Voice Association (IVA) | Audiodateien | Digital Speech Standard File | DSS Player Lite | Olympus Corporation |
| .DTG | Desktop Music | Audiodateien | Desktop Guitar Score File | Desktop Guitar | Desktop Music |
| .DTM | Prodatron | Audiodateien | DigiTrakker Audio Module | CocoModX | Open Source |
| .DTS | CyberLink | Audiodateien | DTS Encoded Audio File | CyberLink PowerDVD | CyberLink |
| .DTSHD | Digital Theater Systems (DTS) Inc. | Audiodateien | DTS-HD Master Audio File | DTS-HD MASTER AUDIO SUITE | Digital Theater Systems (DTS) Inc. |
| .DUB | Interscape | Audiodateien | Tuningwrench Audio Utility Compressed Audio | Tuningwrench | Interscape |
| .DVA | Leitch Technology | Audiodateien | DPS Velocity Split Audio | DPS Velocity | Leitch Technology |
| .DVC | IBM | Audiodateien | Lotus 1-2-3 Data | Lotus 1-2-3 | IBM |
| .DVF | Sony | Audiodateien | Sony Digital Voice File | Microsoft Windows Media Player | Microsoft Corporation |
| .DVW | Dektron | Audiodateien | Dektron Digital Voice Recorder Audio Data | Dektron Digital Voice Recorder | Dektron |
| .DW | Un4seen Developments | Audiodateien | David Whittaker Audio File | DeliPlayer | Open Source |
| .DWA | Alex Gavrilov | Audiodateien | Digital Waveform Archiver Audio File | DWA Coder | DWA Coder |
| .DWD | DiamondWare Ltd. | Audiodateien | DiamondWare Digital Audio File | Wi-Fone | DiamondWare Ltd. |
| .D_ | Unknown Developer | Audiodateien | Seqmax Seqprest Compressed Audio File | Unknown Software | Unknown Developer |
| .EAR | Oracle Corporation | Audiodateien | Java Enterprise Archive File | WebSphere Application Server | IBM |
| .EC3 | Epson US | Audiodateien | EPSON Print CD File | EPSON Print CD | Epson US |
| .ECELP7470 | Nuera Communications | Audiodateien | Nuera Audio File | Unknown Software | Unknown Developer |
| .EFA | Chicken Systems | Audiodateien | Ensoniq ASR File | Chicken Systems Translator | Chicken Systems |
| .EFE | E-mu Systems | Audiodateien | Ensoniq EPS File | Chicken Systems Ensoniq Disk Tools | Chicken Systems |
| .EFK | FMJ-Software | Audiodateien | Ensoniq KT Instrument File | Awave Studio | FMJ-Software |
| .EFQ | Chicken Systems | Audiodateien | Ensoniq SQ1/SQ2/KS-32 File | Chicken Systems Translator | Chicken Systems |
| .EFS | ESRI | Audiodateien | ESRI Spatial Binary File | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .EFV | Chicken Systems | Audiodateien | Ensoniq VFX-SD File | Chicken Systems Translator | Chicken Systems |
| .ELIST | Diekollegen.at | Audiodateien | Emperor Media Player Playlist File | Emperor Media Player | Diekollegen.at |
| .EMB | Everest Software | Audiodateien | Everest Embedded Bank File | Awave Studio | FMJ-Software |
| .EMD | FMJ-Software | Audiodateien | ABT Extended Module File | Awave Studio | FMJ-Software |
| .EMP | Open Source | Audiodateien | eMusic Music Download File | eMusic/J | Open Source |
| .EMX | Open Source | Audiodateien | eMusic Download File | eMusic/J | Open Source |
| .EMY | Sony | Audiodateien | eMelody Ringtone File | Sony Ericsson Mobile Phones | Sony Mobile Communications |
| .ENF | Thomson Reuters Corporation | Audiodateien | EndNote Filter File | EndNote | Thomson Reuters Corporation |
| .ENS | Thomson Reuters Corporation | Audiodateien | EndNote Style File | EndNote | Thomson Reuters Corporation |
| .EOP | Everyone Piano Inc. | Audiodateien | EveryonePiano Music Score File | Everyone Piano | Everyone Piano Inc. |
| .EOV | Epson US | Audiodateien | Epson Voice Creation Tool Voice Data | Voice Creation Tool | Epson US |
| .EPM | THE BAKED BEAN COMPANY | Audiodateien | Electric Pipes Music | Electric Pipes | THE BAKED BEAN COMPANY |
| .EPT | Adobe Systems Incorporated | Audiodateien | Adobe Encapsulated PostScript Interchange Format With TIFF Preview | Adobe Acrobat DC | Adobe Systems Incorporated |
| .ERB | Open Source | Audiodateien | Ruby ERB Script | Microsoft Notepad | Microsoft Corporation |
| .ES | Interscape | Audiodateien | ECHOSPEECH File | ECHOSPEECH | Interscape |
| .ESPS | Various Developers | Audiodateien | ESPS Sampled Data File | The Hidden Markov Model Toolkit (HTK) | Machine Intelligence Laboratory |
| .ESU | Electronic Solutions Ulm | Audiodateien | LokSound Electronic Sound File | LokSound | Electronic Solutions Ulm |
| .ETA | Google | Audiodateien | Google Earth Placemark File | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
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