| .RVG | Autodesk, Inc. | Datové soubory | Revit External Group File | Revit | Autodesk, Inc. |
| .RVL | muvee | Datové soubory | Muvee Reveal X Project File | muvee Reveal X | muvee |
| .RVT | Autodesk, Inc. | Datové soubory | Revit Project File | AutoCAD Architecture | Autodesk, Inc. |
| .RVW | Element River, LLC. | Datové soubory | ReviewMate Review File | ReviewMate | Element River, LLC. |
| .RW5 | Spectra Precision | Datové soubory | Survey Pro Data File | Survey Pro | Spectra Precision |
| .RWA | ReliaSoft | Datové soubory | Weibull++ File | ReliaSoft Weibull++ | ReliaSoft |
| .RWD | NRG Systems | Datové soubory | NRG Raw Wind Data File | Symphonie Data Retriever | NRG Systems |
| .RWG | Gammadyne Corp | Datové soubory | Random Word Generator Project File | Gammadyne Random Word Generator | Gammadyne Corp |
| .RWS | Ludeon Studios | Datové soubory | RimWorld Game Save File | Ludeon Studios RimWorld | Ludeon Studios |
| .RWX | AOL | Datové soubory | Netscape Live 3D File | Netscape Navigator | NetScape |
| .RX | Microsoft Corporation | Datové soubory | MS-DOS 7 Data | Microsoft Windows | Microsoft Corporation |
| .RXC | Sonic Solutions | Datové soubory | Roxio Certificate File | Roxio Creator NXT Pro 6 | Roxio |
| .RXF | Resort Software | Datové soubory | Recipe Exchange Format | Resort Recipe | Resort Software |
| .RXPROJ | ENTERBRAIN, INC. | Datové soubory | RPG Maker Project | RPG Maker VX | ENTERBRAIN, INC. |
| .RXS | Remedy Interactive, Inc. | Datové soubory | RSIGuard RSIScript File | RSIGuard | Remedy Interactive, Inc. |
| .S01 | Lithops Software | Datové soubory | ZipSplitter Part 2 Archive | Lithops Software ZipSplitter | Lithops Software |
| .S03 | Corel Corporation | Datové soubory | Corel WordPerfect Distribution File | Corel WordPerfect | Corel |
| .S2 | Motorola | Datové soubory | Motorola S-record Format | Unknown Software | Unknown Developer |
| .S2P | Sonnet Software | Datové soubory | Sonnet S-device Parameter Data File | Sonnet Suites | Sonnet Software |
| .S2R | Unknown Developer | Datové soubory | RegMagik File | RegMagik | Unknown Developer |
| .S31 | TamoSoft | Datové soubory | SmartWhois File | SmartWhois | TamoSoft |
| .S4D | RIAM (French National Network for Research and Innovation on Multimedia) | Datové soubory | RIAM AVA Motion S4D Data | AVA Motion | RIAM (French National Network for Research and Innovation on Multimedia) |
| .S4MI | Motorola | Datové soubory | Motorola Skin Editor Data File | Motorola Skin Editor | Motorola |
| .S4P | Open Source | Datové soubory | Touchstone 16 S-parameters Data File | Notepad++ | Don Ho |
| .S4T | i4i, Inc | Datové soubory | S4/TEXT And Tagless Editor Data | Unknown Software | Unknown Developer |
| .S7F | Siemens AG | Datové soubory | STEP 7 Project | Step 7-Micro/WIN | Siemens AG |
| .S7S | Sony | Datové soubory | Sony Ericsson S700i Phone Firmware Data | Sony Ericsson Mobile Phones | Sony Mobile Communications |
| .S8 | SIMUL8 | Datové soubory | SIMUL8 Simulation Data | SIMUL8 | SIMUL8 |
| .S85 | sabre airline solutions | Datové soubory | SABRE StaffPlan Chart | SABRE staffplan software | sabre airline solutions |
| .SAA | Information Security Corporation (ISC) | Datové soubory | SecretAgent Encrypted Archive File | SecretAgent | Information Security Corporation (ISC) |
| .SAD | LucasArts Entertainment Company, LLC | Datové soubory | Lucas Arts Sound Data | Dragon UnPACKer | Open Source |
| .SAF | DeLorme | Datové soubory | Street Atlas USA Map File | DeLorme Street Atlas USA | DeLorme |
| .SAH | Berkeley Systems | Datové soubory | SETI@home Data File | BOINC | University of California, Berkeley |
| .SAL | Oracle Corporation | Datové soubory | SQL Application Language Source Code | MySQL | Oracle Corporation |
| .SAM | Microsoft Corporation | Datové soubory | LMHOSTS Sample File | Notepad++ | Don Ho |
| .SAMPLE | Unknown Developer | Datové soubory | Saved Sample | Unknown Software | Unknown Developer |
| .SAPSSD | SAP | Datové soubory | SAP Data | SAP Business All-In-One | SAP |
| .SAR | Commodore International | Datové soubory | Saracen Paint Image | XnView MP | XnSoft |
| .SAS7BCAT | SAS Institute Inc. | Datové soubory | SAS Version 8 Random Access File Catalog | SAS | SAS Institute Inc. |
| .SAV | Nintendo | Datové soubory | Saved Game File | No Cash GBA (No$GBA) | Martin Korth |
| .SAX | Open Source | Datové soubory | Sedona Framework XML Application | Sedona Framework | Open Source |
| .SBA | SpeedBalance.nl | Datové soubory | SpeedBalance Accounting Data | SpeedBalance | SpeedBalance.nl |
| .SBD | Microsoft Corporation | Datové soubory | Office Accounting Company Data File | Microsoft Office Accounting | Microsoft Corporation |
| .SBF | Google | Datové soubory | Android System File | Google Android | Google |
| .SBI | Creative Technology Ltd. | Datové soubory | Sound Blaster Instrument | Virtual Sound Blaster | Creative Technology Ltd. |
| .SBK | SwishZone | Datové soubory | SWiSH Project Backup File | SWiSH Max | SwishZone |
| .SBL | Adobe Systems Incorporated | Datové soubory | Shockwave Flash Object | Adobe Flash Player | Adobe Systems Incorporated |
| .SBP | Autodesk, Inc. | Datové soubory | Sketchbook Express iCloud Image | SketchBook | Autodesk, Inc. |
| .SBS | Allegorithmic | Datové soubory | Substance Package | Substance Designer | Allegorithmic |
| .SBT | URUWORKS | Datové soubory | SBT Subtitle File | URUWorks Subtitle Workshop | URUWORKS |
| .SBW | US Treasury | Datové soubory | US Treasury Savings Bonds Wizard File | US Treasury Savings Bond Wizard | US Treasury |
| .SBX | Dream Design Entertainment Software | Datové soubory | GLBasic Shoebox File | GLBasic | Dream Design Entertainment Software |
| .SC3 | EA Maxis | Datové soubory | SimCity 3000 City File | Maxis SimCity 3000 | EA Maxis |
| .SCA | Symantec Corporation | Datové soubory | Norton AntiVirus Scan File | Norton Antivirus | Symantec Corporation |
| .SCD | Intuit, Inc. | Datové soubory | TurboTax Tax Schedule List | Intuit Quicken | Quicken |
| .SCE | Open Source | Datové soubory | Scilab Script | Scilab | Open Source |
| .SCF | Microsoft Corporation | Datové soubory | Windows Explorer Command | Microsoft Windows | Microsoft Corporation |
| .SCG | Midori Media | Datové soubory | MyPM SCG Definition File | Midori Media myPM SCG Classic | Midori Media |
| .SCH | Autodesk, Inc. | Datové soubory | EAGLE Schematics File | Autodesk EAGLE | Autodesk, Inc. |
| .SCI | Open Source | Datové soubory | Scilab Script | Scilab | Open Source |
| .SCL | Avid Technology | Datové soubory | Sibelius Chord Diagram Library | Avid Sibelius | Avid Technology |
| .SCM | Gimpel Software | Datové soubory | GIMP Script-Fu Script | GIMP | The GIMP Development Team |
| .SCN | Microsoft Corporation | Datové soubory | Age Of Mythology Scenario File | Microsoft Age of Empires | Ensemble Studios |
| .SCO | MR Software | Datové soubory | OMSI Scenery Object Configuration File | OMSI | MR Software |
| .SCORES | Unknown Developer | Datové soubory | Unknown Apple II File. (found On Golden Orchard Apple II CD Rom) | Atom | GitHub, Inc. |
| .SCS_TOR | Accelrys Software Inc. | Datové soubory | Insight II Torsion File | Insight II | Accelrys Software Inc. |
| .SCX | RIX SoftWorks, Inc. | Datové soubory | ColoRIX Bitmap Graphic File | XnView MP | XnSoft |
| .SCZ | OpenLimit SignCubes AG | Datové soubory | OpenLimit SignCubes Zip Container File | OpenLimit CC Sign | OpenLimit SignCubes AG |
| .SDA | Oracle Corporation | Datové soubory | StarOffice Drawing | Apache OpenOffice | Apache Software Foundation |
| .SDC | Stardock Corporation | Datové soubory | Stardock Central Download Archive | Stardock Central | Stardock Corporation |
| .SDD | Programming Sunrise | Datové soubory | Smart Diary Suite Data File | Smart Diary Suite | Programming Sunrise |
| .SDE | Groundlevel Software, Inc. | Datové soubory | Drumbeat Exported Data File | DrumBeat | Groundlevel Software, Inc. |
| .SDF | Microsoft Corporation | Datové soubory | SQL Server Compact Database File | Microsoft Visual Studio | Microsoft Corporation |
| .SDI | Intuit, Inc. | Datové soubory | QuickBooks Data File | Intuit QuickBooks Pro | Intuit, Inc. |
| .SDK | Autodesk, Inc. | Datové soubory | AutoSketch Drawing | AutoSketch | Autodesk, Inc. |
| .SDL | Microsoft Corporation | Datové soubory | Service Description Language File | Safari | Apple |
| .SDM | Oracle Corporation | Datové soubory | StarOffice Mail Message | StarOffice | Oracle Corporation |
| .SDN | Robert K. Jung | Datové soubory | Shareware Distributors Network File | ARJ Software JAR | Robert K. Jung |
| .SDOC | Samsung Electronics | Datové soubory | Samsung Memo File | Samsung Kies | Samsung Electronics |
| .SDP | Oracle Corporation | Datové soubory | StarOffice Presentation File | Apache OpenOffice | Apache Software Foundation |
| .SDS | Oracle Corporation | Datové soubory | OpenOffice.org Chart | Apache OpenOffice | Apache Software Foundation |
| .SDT | Intuit, Inc. | Datové soubory | QuickBooks Data File | Intuit QuickBooks Pro | Intuit, Inc. |
| .SDU | Edwards Systems Technology, Inc. | Datové soubory | Edwards Systems Technology File | Unknown Software | Unknown Developer |
| .SDV | Pinnacle Systems Inc. | Datové soubory | Studio DV Project File | Pinnacle Studio | Corel |
| .SDX | Kivuto | Datové soubory | Kivuto Secure Download Manager File | Kivuto Secure Download Manager | Kivuto |
| .SDY | StarMoney | Datové soubory | StarMoney Financial Data | StarMoney | StarMoney |
| .SEARCHCONNECTOR-MS | Microsoft Corporation | Datové soubory | Microsoft Windows Search Connector Description File | Microsoft Windows | Microsoft Corporation |
| .SECURITY | Oracle Corporation | Datové soubory | Javasoft Jre 1.3 Lib Security Data | Java | Oracle Corporation |
| .SEED | Open Source | Datové soubory | Linux Preseed File | Ubuntu | Open Source |
| .SEG | SEG (The Society of Exploration Geophysicists) | Datové soubory | SEG-2 Data File | Unknown Software | Unknown Developer |
| .SEL | Mincom | Datové soubory | LinkOne Selection List File | Mincom LinkOne WebView | Mincom |
| .SEM | Alpha Software | Datové soubory | Alpha Five Set Data Dictionary Memo File | Alpha Anywhere - Alpha Software | Alpha Software |
| .SEN | Neyer Software LLC | Datové soubory | SenTest Data File | Neyer Software SenTest | Neyer Software LLC |
| .SEO | Link Engine Management Ltd. | Datové soubory | PC Link File | PC Link | Link Engine Management Ltd. |
| .SEP | PictView software | Datové soubory | Separated Image File | PictView | PictView software |
| .SEQ | PG Music Inc | Datové soubory | PowerTracks Pro Audio Project File | PowerTracks Pro Audio | PG Music Inc |
| .SER | Thermo Fisher Scientific Inc. | Datové soubory | GeneMapper Project File | GeneMapper | Thermo Fisher Scientific Inc. |
| .SERIAL | Apple | Datové soubory | Golden Orchard Apple II CD Rom File | Apple OS X | Apple |
| .SERVER | Interscape | Datové soubory | Bonobo Activation API File | GNOME Desktop | Interscape |
| .SETUP | Crytek | Datové soubory | CryENGINE Character Setup File | Crytek CryENGINE SDK | Crytek |
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