| .EPP | Talasoft | Datové soubory | TalaPhoto Project | TalaPhoto | Talasoft |
| .EPT | Adobe Systems Incorporated | Datové soubory | Adobe Encapsulated PostScript Interchange Format With TIFF Preview | Adobe Acrobat DC | Adobe Systems Incorporated |
| .EPW | U.S. Department of Energy | Datové soubory | EnergyPlus Weather Data File | EnergyPlus | U.S. Department of Energy |
| .EPZ | EON Reality | Datové soubory | EON Studio Personal Edition File | EON Studio | EON Reality |
| .EQD | Cattlesoft, Inc. | Datové soubory | EquineMax Data File | EquineMax | Cattlesoft, Inc. |
| .EQW | Petr Skoda | Datové soubory | SPEFO Stellar Spectra Analysis File | SPEFO | Astronomical Institute of the Czech Academyof Sciences |
| .ER1 | CA Technologies | Datové soubory | ERWin Entity Relationship Diagram | ERwin | CA Technologies |
| .ER2 | Apple | Datové soubory | Golden Orchard Apple II CD Rom File | Apple OS X | Apple |
| .ERD | Open Source | Datové soubory | Entity Relation Diagram | DBeaver | Open Source |
| .ERE | EagleEyeOS LLC. | Datové soubory | EagleEyeOS Report File | EagleEyeOS | Eagle Eye Digital Solutions (EEDS) |
| .ERG | RacerMate Inc. | Datové soubory | CompuTrainer Workout File | CompuTrainer | RacerMate Inc. |
| .ERI | XnSoft | Datové soubory | ERI-chan (Entis Rasterized Image) Image Format | XnView MP | XnSoft |
| .ERIC | Apple | Datové soubory | Golden Orchard Apple II CD Rom File | Apple OS X | Apple |
| .ERP | Future Games | Datové soubory | Alter Ego Game Archive | Alter Ego | Future Games |
| .ERWIN | CA Technologies | Datové soubory | ERwin Data Modeler Model | ERwin | CA Technologies |
| .ES | Interscape | Datové soubory | ECHOSPEECH File | ECHOSPEECH | Interscape |
| .ESB | Season Workshop | Datové soubory | Es-Builder Book File | Season Workshop es-Builder | Season Workshop |
| .ESJ | Thermwood Corporation | Datové soubory | eCabinet CAD File | eCabinet Systems | Thermwood Corporation |
| .ESK | Interactive Data Corporation | Datové soubory | eSignal Scan File | eSignal | Interactive Data Corporation |
| .ESO | Design Builder | Datové soubory | DesignBuilder EnergyPlus Output File | DesignBuilder | Design Builder |
| .ESP | Bethesda Softworks | Datové soubory | Elder Scrolls Plugin File | Bethesda Softworks TES Construction Set | Bethesda Softworks |
| .ESR | 4D, Inc | Datové soubory | 4D Database External Data | 4D | 4D, Inc |
| .ESS | Bethesda Softworks | Datové soubory | The Elder Scrolls Saved Game | Skyrim VR | Bethesda Softworks |
| .EST | Microsoft Corporation | Datové soubory | Streets & Trips Map File | Microsoft MapPoint | Microsoft Corporation |
| .ESX | Xactware Solutions | Datové soubory | Xactimate Insurance Claims Estimate | Xactimate | Xactware Solutions |
| .ET | RM Education | Datové soubory | Easiteach Lesson File | Research Machines Easiteach | RM Education |
| .ET1 | Unknown Developer | Datové soubory | Energy 10 Weather Data | Energy 10 | Open Source |
| .ET3 | Microsec Software Engineering & Consulting Plc. | Datové soubory | E-Szigno Recorded Delivery Data | e-Szigno | Microsec Software Engineering & Consulting Plc. |
| .ETB | Project Pluto | Datové soubory | Project Pluto Guide Event Table | Project Pluto Guide | Project Pluto |
| .ETBP | Textbook Solutions Limited | Datové soubory | eTextbookCreator Project File | eTextbookCreator | Textbook Solutions Limited |
| .ETH | Qualis Research Associates | Datové soubory | Ethnograph Document | Qualis Research Associates Ethnograph | Qualis Research Associates |
| .ETP | Microsoft Corporation | Datové soubory | Visual Studio Enterprise Template Project | Microsoft Visual Studio | Microsoft Corporation |
| .ETS | Enthuware | Datové soubory | Enthuware Test Studio Document | Enthuware Test Studio | Enthuware |
| .ETT | Kingsoft | Datové soubory | Kingsoft Spreadsheets Template | WPS Office | Kingsoft |
| .EUHL | Qualcomm | Datové soubory | Eudora For Mac Help File | QUALCOMM Eudora | Qualcomm |
| .EUK | Moziak Digital Learning | Datové soubory | Euklides Dynamic Geometry | Euklides | Moziak Digital Learning |
| .EUP | Jerome Lamy | Datové soubory | EagleUp Data | EagleUp | Jerome Lamy |
| .EUX | Intelligent Software | Datové soubory | Eulogica Funeral Information | Eulogica | Intelligent Software |
| .EV | Echoview Software Pty Ltd | Datové soubory | Echoview File | Echoview | Echoview Software Pty Ltd |
| .EV3 | The LEGO Group | Datové soubory | LEGO MINDSTORMS EV3 Project | LEGO MINDSTORMS EV3 | The LEGO Group |
| .EVC | DeskSoft | Datové soubory | Earthview Data File | Earthview | DeskSoft |
| .EVE | Open Source | Datové soubory | Embedded Vector Editor Diagram | Embedded Vector Editor | Open Source |
| .EVI | Echoview Software Pty Ltd | Datové soubory | Echoview Index File | Echoview | Echoview Software Pty Ltd |
| .EVL | Echoview Software Pty Ltd | Datové soubory | EchoView Exported Line File | Echoview | Echoview Software Pty Ltd |
| .EVY | Corel | Datové soubory | Corel Envoy Document | Corel WordPerfect | Corel |
| .EWF | Open Source | Datové soubory | Trollzsoft EpicWriter File | EpicWriter | Open Source |
| .EWG | Dassault Systèmes | Datové soubory | SolidWorks File Format | SOLIDWORKS | Dassault Systèmes |
| .EWS | Softouch Development, Inc | Datové soubory | EasyWorship Schedule File | EasyWorship | Softouch Development, Inc |
| .EX2 | Unknown Developer | Datové soubory | Exodus II File | Exodus II | Unknown Developer |
| .EX4 | MetaQuotes Software Corp | Datové soubory | MetaTrader Program Format | MetaQuotes MetaTrader | MetaQuotes Software Corp |
| .EXB | CAXA | Datové soubory | CAXA Draft | IronCAD | IronCAD, LLC |
| .EXC | Lionhead Studios | Datové soubory | Black & White Zone File | Lionhead Studios Black and White | Lionhead Studios |
| .EXE2 | Unknown Developer | Datové soubory | Unknown Apple II File. (found On Golden Orchard Apple II CD Rom) | Atom | GitHub, Inc. |
| .EXEMPLE | Apple | Datové soubory | Golden Orchard Apple II CD Rom File | Apple OS X | Apple |
| .EXF | Open Source | Datové soubory | Exchangeable Image File Format | Photo Studio | Open Source |
| .EXI | exida.com | Datové soubory | ExSILentia Project | exSILentia | exida.com |
| .EXL | SysTools Solutions | Datové soubory | Export Lister File | SysTools Export Notes | SysTools Solutions |
| .EXM | Boson Holdings | Datové soubory | Boson Exam File | Boson Exam Environment | Boson Holdings |
| .EXP | Unknown Developer | Datové soubory | Symbols Export File | Microsoft Visual Studio | Microsoft Corporation |
| .EXPLOSION | Apple | Datové soubory | Golden Orchard Apple II CD Rom File | Apple OS X | Apple |
| .EYE | EyeMail Technology Inc. | Datové soubory | Eyemail Video Recording File | ETI Monet TV | EyeMail Technology Inc. |
| .EZD | Julio Gómez Herrero & José María Gómez Rodríguez | Datové soubory | WSxM Image Data | WSxM | Julio Gómez Herrero & José María Gómez Rodríguez |
| .F | The Eclipse Foundation | Datové soubory | Fortran Source Code | MacroMates TextMate | MacroMates |
| .F#+A | RagTime.de Development | Datové soubory | RagTime Classic File | RagTime | RagTime.de Development |
| .F#+D | RagTime.de Development | Datové soubory | RagTime Classic File | RagTime | RagTime.de Development |
| .F01 | U.S. Army Corps of Engineers | Datové soubory | HEC-RAS Flow File | HEC-RAS | U.S. Army Corps of Engineers |
| .F03 | The Eclipse Foundation | Datové soubory | Fortran Source Code | MacroMates TextMate | MacroMates |
| .F04 | U.S. Army Corps of Engineers | Datové soubory | HEC-RAS Flow File | HEC-RAS | U.S. Army Corps of Engineers |
| .F05 | U.S. Army Corps of Engineers | Datové soubory | HEC-GeoRAS Flow Data | HEC-RAS | U.S. Army Corps of Engineers |
| .F15 | BALARAD | Datové soubory | Embird Embroidery Software Data | Embird Embroidery Software | BALARAD |
| .F2 | ASUS | Datové soubory | Biosflash File | Windows BIOS Flash Utility | ASUS |
| .F2F | Byteworx | Datové soubory | Byteworx FMEA Exported Data File | Byteworx FMEA | Byteworx |
| .F3D | Autodesk, Inc. | Datové soubory | Fusion 3D Design | Autodesk Fusion 360 | Autodesk, Inc. |
| .F3G | GIGABYTE | Datové soubory | GIGABYTE BIOS Update | GIGABYTE Firmware Update Utility | GIGABYTE |
| .F4F | Adobe Systems Incorporated | Datové soubory | Adobe HTTP Dynamic Streaming Segment | Adobe Flash Player | Adobe Systems Incorporated |
| .F4G | GIGABYTE | Datové soubory | GIGABYTE BIOS Update | GIGABYTE Firmware Update Utility | GIGABYTE |
| .F6G | GIGABYTE | Datové soubory | GIGABYTE BIOS Update | GIGABYTE Firmware Update Utility | GIGABYTE |
| .FA | Nucleobytes | Datové soubory | FASTA Formatted Sequence File | SnapGene | GSL Biotech LLC |
| .FAC | Newera Software Technology, Inc. | Datové soubory | FACE Graphic File | Graphics Converter Pro | Newera Software Technology, Inc. |
| .FAF | Thomas Tempelmann | Datové soubory | Find Any File Search Description | Find Any File | Thomas Tempelmann |
| .FAMILYFILE | Leister Productions | Datové soubory | Reunion Family Tree File | Reunion | Leister Productions |
| .FAS | Autodesk, Inc. | Datové soubory | Compiled Fast-Load AutoLISP File | Autodesk AutoCAD | Autodesk, Inc. |
| .FAST | Apple | Datové soubory | Golden Orchard Apple II CD Rom File | Apple OS X | Apple |
| .FASTA | Nucleobytes | Datové soubory | FASTA Sequence File | SnapGene | GSL Biotech LLC |
| .FASTQ | Technelysium | Datové soubory | FASTQ Format | Notepad++ | Don Ho |
| .FAZ | Tandy | Datové soubory | DeskMate Generic Character Data File | DeskMate | Tandy |
| .FB5 | Tranzsoft Group Limited | Datové soubory | FlowBiz Integrator File | FlowBiz | Tranzsoft Group Limited |
| .FBF | Promosoft Corporation | Datové soubory | Free Backup Fix Backup File | Promosoft Free Backup Fix | Promosoft Corporation |
| .FBK | Microsoft Corporation | Datové soubory | Microsoft Dynamics NAV Backup File | Microsoft Dynamics NAV (Navision) | Microsoft Corporation |
| .FBR | Blueberry Software | Datové soubory | FlashBack Screen Recording | Blueberry FlashBack | Blueberry Software |
| .FBS | Interscape | Datové soubory | Fastbid Plan Sheet | Fastbid | Interscape |
| .FBV | VSoft Technologies | Datové soubory | FinalBuilder Persistent Variables File | FinalBuilder | VSoft Technologies |
| .FC | OpenText | Datové soubory | FirstClass Settings File | OpenText FirstClass | OpenText |
| .FC7 | Evolution Computing | Datové soubory | FastCAD Version 7 Drawing | FastCAD | Evolution Computing |
| .FCA | Omnis Software | Datové soubory | Omnis Web Client File | Omnis Studio | Omnis Software |
| .FCB | Interscape | Datové soubory | FAAST Builder Data | FAAST Builder | Interscape |
| .FCH | Gaussian, Inc. | Datové soubory | Gaussian Checkpoint File | Gaussian | Gaussian, Inc. |
| .FCHK | Gaussian, Inc. | Datové soubory | Gaussian Checkpoint | Gaussian | Gaussian, Inc. |
| .FCI | Geognostics | Datové soubory | EROSION 3D Inflow Table | Erosion 3D | Geognostics |
| .FCM | fcraft.net | Datové soubory | fCraft World File | fCraft | fcraft.net |
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