| .E2C | NJStar Software | Datové soubory | NJStar Chinese Word Processor Dictionary File Index | NJStar Chinese WP | NJStar Software |
| .E2P | Open Source | Datové soubory | PonyProg Device File | PonyProg | Open Source |
| .E32 | Jordan Russell | Datové soubory | Inno Setup 1.3 Data | Inno Setup | Open Source |
| .EAC | Emurasoft, Inc. | Datové soubory | EmEditor Auto-Completion Data | EmEditor | Emurasoft, Inc. |
| .EAP | Sparx Systems | Datové soubory | Enterprise Architect Project | Enterprise Architect | Sparx Systems |
| .EAS | Rockwell Automation Inc. | Datové soubory | RSLogix Symbol File | RSLogix 5 | Rockwell Automation Inc. |
| .EATF | Apple | Datové soubory | Golden Orchard Apple II CD Rom File | Apple OS X | Apple |
| .EAZ | ESRI (Environmental Systems Research Institute) | Datové soubory | ArcGIS Explorer Add-in File | Microsoft Visual Studio | Microsoft Corporation |
| .EBB | Metapraxis | Datové soubory | Empower Business Bulletin Data File | Empower | Metapraxis |
| .EBC | SourceForge | Datové soubory | MediaBASIC Compiled Project | MediaBASIC | SourceForge |
| .EBD | Microsoft Corporation | Datové soubory | Windows EBD System File | Microsoft Windows | Microsoft Corporation |
| .EBF | Microsoft Corporation | Datové soubory | Pocket PC WindowsCE Form | Microsoft Windows CE Embedded | Microsoft Corporation |
| .EBH | Robert Bentley, Inc. | Datové soubory | eBahn Desktop Automotive Repair Information Data File | eBahn Desktop | Robert Bentley, Inc. |
| .EBP | Jes-Soft | Datové soubory | Jes-Soft Sports Play Description | Jes-Soft Playbook | Jes-Soft |
| .EBUILD | Gentoo Foundation, Inc. | Datové soubory | Portage eBuild Script | Gentoo Portage | Gentoo Foundation, Inc. |
| .EBV | ASH WARE | Datové soubory | Ash Ware Enhanced Behavior Data | Unknown Software | Unknown Developer |
| .EBX | IBM | Datové soubory | Rational Rose 98 Compiled Script | Rational Rose | IBM |
| .EC3 | Epson US | Datové soubory | EPSON Print CD File | EPSON Print CD | Epson US |
| .ECC | Carsten Gnörlich | Datové soubory | Dvdisaster Error Correction File | dvdisaster | Carsten Gnörlich |
| .ECF | Microsoft Corporation | Datové soubory | Outlook Add-in | Microsoft Outlook | Microsoft Corporation |
| .ECG | Open Source | Datové soubory | Electrocardiography Data | FreeECG | Open Source |
| .ECH | SourceForge | Datové soubory | EasyChem Saved Data | EasyChem | SourceForge |
| .ECL | Team Shanghai Alice | Datové soubory | Touhou Stage Script | Touhou ToolKit | Touhou Patch Center |
| .ECP | Intelitek | Datové soubory | EasyC Project File | EasyC | Intelitek |
| .ECT | Yozosoft | Datové soubory | Yozo Office Chart Template File | Yozosoft Yozo Office | Yozosoft |
| .EDD | Adobe Systems Incorporated | Datové soubory | Adobe FrameMaker Element Definition Document File | Adobe FrameMaker | Adobe Systems Incorporated |
| .EDF | ESRF | Datové soubory | ESRF Data File | SAXS Program Package | ESRF |
| .EDG | Pacestar Software | Datové soubory | Edge Diagrammer File | Pacestar Edge Diagrammer | Pacestar Software |
| .EDH | MindWare Technologies | Datové soubory | HRV Edit Data | Heart Rate Variability (HRV) Analysis Software | MindWare Technologies |
| .EDI | Unknown Developer | Datové soubory | Electronic Data Interchange File | Microsoft Excel | Microsoft Corporation |
| .EDP | National Instruments | Datové soubory | NI Multisim Data | NI Multisim | National Instruments |
| .EDPI | PrestoSoft LLC | Datové soubory | ExamDiff Pro Session File | ExamDiff Pro | PrestoSoft LLC |
| .EDT | Adobe Systems Incorporated | Datové soubory | Adobe eBook Download Settings | Adobe Digital Editions | Adobe Systems Incorporated |
| .EEG | Compumedics Neuroscan | Datové soubory | EEG Data File | Neuroscan Curry | Compumedics Neuroscan |
| .EEP | Open Source | Datové soubory | EEPROM Data File | HHD Hex Editor | HHD Software |
| .EER | Lahey Computer Systems, Inc. | Datové soubory | Lahey Fortran Error Data | Lahey Fortran | Lahey Computer Systems, Inc. |
| .EF | Blackboard Collaborate | Datové soubory | Diploma Exam File | Wimba Diploma | Blackboard Collaborate |
| .EFC | Unknown Developer | Datové soubory | EFCoins File | Unknown Software | Unknown Developer |
| .EFP | Microsoft Corporation | Datové soubory | Exchange Forms Designer Template | Microsoft Exchange Server | Microsoft Corporation |
| .EFS | ESRI | Datové soubory | ESRI Spatial Binary File | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .EFT | Cay Horstmann | Datové soubory | ChiWriter High Resolution Screen Font | ChiWriter | Cay Horstmann |
| .EFX | j2 Global, Inc. | Datové soubory | eFax Document | j2 Global Communications eFax | j2 Global, Inc. |
| .EGB | Encog Machine Learning Framework | Datové soubory | Encog Binary Data | Encog Machine Learning Framework | Encog Machine Learning Framework |
| .EGF | CSC - IT Center for Science | Datové soubory | Elmer Front Geometry Definition Data | Elmer Front | CSC - IT Center for Science |
| .EGP | Edline | Datové soubory | Easy Grade Pro Gradebook File | Edline Easy Grade Pro | Edline |
| .EGR | Crestron Electronics | Datové soubory | Crestron Studio Engraver Document File | Crestron Studio | Crestron Electronics |
| .EGT | EagleGet | Datové soubory | EagleGet Temporary File | EagleGet | EagleGet |
| .EGV | Canon Inc. | Datové soubory | Canon Easy Guide Viewer File | Canon Easy Guide Viewer | Canon Inc. |
| .EIA | Excellon Automation | Datové soubory | Excellon Data | Microsoft Notepad | Microsoft Corporation |
| .EID | IBM | Datové soubory | IBM Voice Type Languages Newuser File | IBM Voice Type | IBM |
| .EIF | Envex Solutions | Datové soubory | Envex Import Format File | xFlow | Envex Solutions |
| .EIO | Yozosoft | Datové soubory | Yozo Office File | Yozosoft Yozo Office | Yozosoft |
| .EIS | Synthesoft, Inc. | Datové soubory | EIS Spectrum Analyser Project | CD/Spectrum Pro | Synthesoft, Inc. |
| .EKA | Borland | Datové soubory | Eureka Internal Data File | Unknown Software | Unknown Developer |
| .EKB | ZMC | Datové soubory | ZMC Visual Tablet Data | ZMC VisualTablet for AutoCAD | ZMC |
| .EKR | EEG Store | Datové soubory | EEGer Data | EEGer | EEG Store |
| .EKS | Metapraxis | Datové soubory | Metapraxis Empower Data File | Empower | Metapraxis |
| .EL | GNU Project | Datové soubory | Emacs Lisp Code File | GNU Emacs | GNU Project |
| .EL2 | Canon Inc. | Datové soubory | Easy-PhotoPrint EX Sticker File | Easy-PhotoPrint EX | Canon Inc. |
| .EL3 | Canon Inc. | Datové soubory | Canon Easy-PhotoPrint EX File | Easy-PhotoPrint EX | Canon Inc. |
| .ELC | GNU Project | Datové soubory | Emacs Compiled Lisp File | GNU Emacs | GNU Project |
| .ELD | DIAL | Datové soubory | Eulumdat Formatted Luminaire Data File | DIAL DIALux | DIAL |
| .ELG | Energy Scitech Limited | Datové soubory | Enable Activity Log | ENABLE Software | Energy Scitech Limited |
| .ELI | Novarm | Datové soubory | DipTrace Data | DipTrace | Novarm |
| .ELL | Advanced Micro Devices, Inc. | Datové soubory | AMD ATI Radeon Video Driver | ATI Multimedia Center | Advanced Micro Devices, Inc. |
| .ELN | Blackboard Collaborate | Datové soubory | Blackboard Collaborate Note Document | Unknown Software | Unknown Developer |
| .ELOG | McAfee, Inc. | Datové soubory | McAffee Firewall Log File | McAfee Internet Security | McAfee, Inc. |
| .ELP | Open Source | Datové soubory | eXe Learning Package File | eXeLearning | Open Source |
| .ELS | TradeStation | Datové soubory | EasyLanguage Storage File | EasyLanguage | TradeStation |
| .ELSEWHERE | Unknown Developer | Datové soubory | Unknown Apple II File. (found On Golden Orchard Apple II CD Rom) | Atom | GitHub, Inc. |
| .ELT | NEPLAN AG | Datové soubory | NEPLAN Topology Data | NEPLAN Electricity | NEPLAN AG |
| .EMAT | ANSYS, Inc. | Datové soubory | ANSYS Element Matrix File | ANSYS DesignModeler | ANSYS, Inc. |
| .EMB | Everest Software | Datové soubory | Everest Embedded Bank File | Awave Studio | FMJ-Software |
| .EMBL | European Molecular Biology Laboratory (EMBL) | Datové soubory | EMBL Sequence Data File | DNASTAR Lasergene | DNASTAR |
| .EMD | FMJ-Software | Datové soubory | ABT Extended Module File | Awave Studio | FMJ-Software |
| .EMP | Open Source | Datové soubory | eMusic Music Download File | eMusic/J | Open Source |
| .EMS | Intergraph Corporation | Datové soubory | Intergraph Engineering Modelling System File | Unknown Software | Unknown Developer |
| .ENB | Open Source | Datové soubory | eNotebook Notebook File | eNotebook | Open Source |
| .ENC | Smith Micro Software | Datové soubory | Encoded Data File | Smith Micro StuffIt Deluxe | Smith Micro Software |
| .END | Corel | Datové soubory | CorelDRAW Arrow-head Definition Data | CorelDRAW Graphics Suite | Corel |
| .ENE | KTH Royal Institute of Technology | Datové soubory | GROMACS Binary Energy File | Gromacs | KTH Royal Institute of Technology |
| .ENG | Unknown Developer | Datové soubory | Chess Engine | ChessMaster | Ubisoft Blue Byte |
| .ENH | Open Source | Datové soubory | CRiSP Harvest Model Enhancement File | CRiSP Harvest | Open Source |
| .ENL | Thomson Reuters Corporation | Datové soubory | EndNote Library | EndNote | Thomson Reuters Corporation |
| .ENM | e-undertown | Datové soubory | Enewsletter Manager Message File | eNewletter Manager | e-undertown |
| .ENS | Thomson Reuters Corporation | Datové soubory | EndNote Style File | EndNote | Thomson Reuters Corporation |
| .ENV | Adobe Systems Incorporated | Datové soubory | Adobe Dictionary Data File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .ENX | IBM | Datové soubory | IBM Rational XDE Data | Rational XDE | IBM |
| .EON | EON Reality | Datové soubory | EON Studio File | EON Studio | EON Reality |
| .EOP | Everyone Piano Inc. | Datové soubory | EveryonePiano Music Score File | Everyone Piano | Everyone Piano Inc. |
| .EOT | Microsoft Corporation | Datové soubory | Embedded OpenType Font | Web Embedding Fonts Tool (WEFT) | Microsoft Corporation |
| .EOX | EON Reality | Datové soubory | EON Studio Project | EON Studio | EON Reality |
| .EOZ | EON Reality | Datové soubory | EON Studio File | EON Studio | EON Reality |
| .EPB | WebWorks | Datové soubory | ePublisher File | ePublisher | WebWorks |
| .EPC | Sumo Digital Ltd. | Datové soubory | Doctor Who Game Data File | BBC Doctor Who: The Adventure Games | Sumo Digital Ltd. |
| .EPF | Vero Software | Datové soubory | Edgecam Educational Part File | Planit Edgecam | Vero Software |
| .EPJ | Grass Valley | Datové soubory | EDIUS Pro Project File | Thomson EDIUS | Grass Valley |
| .EPL | Open Source | Datové soubory | Tallyman E-commerce Software File | TallyMan | Open Source |
| .EPP | Talasoft | Datové soubory | TalaPhoto Project | TalaPhoto | Talasoft |
| .EPT | Adobe Systems Incorporated | Datové soubory | Adobe Encapsulated PostScript Interchange Format With TIFF Preview | Adobe Acrobat DC | Adobe Systems Incorporated |
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