| .R3P | Yamaha Corporation | Zvukové soubory | RS7000 | RS7000 Vintage Synth Explorer | Yamaha Corporation |
| .RA | RealNetworks | Zvukové soubory | Real Audio File | VLC Media Player | VideoLAN |
| .RAD | Reality Pump Studios | Zvukové soubory | Reality Adlib Tracker Module | Adlib Tracker II | Adlib Tracker II |
| .RAM | RealNetworks | Zvukové soubory | Real Audio Metadata File | JRiver Media Center | JRiver |
| .RAW | Unknown Developer | Zvukové soubory | Raw Image Data File | MacPhun ColorStrokes | Macphun |
| .RAX | RealNetworks | Zvukové soubory | Real Music Store Audio File | RealPlayer | Realtime Technologies |
| .RBS | Microsoft Corporation | Zvukové soubory | Windows Installer Rollback Script File | Windows Installer | Microsoft Corporation |
| .RCY | Propellerhead | Zvukové soubory | ReCycle 1.x Document | ReCycle | Propellerhead |
| .REL | Nintendo | Zvukové soubory | Relocatable Module File | Stage Switcher | Unknown Developer |
| .REX | Propellerhead | Zvukové soubory | ReCycle Loop File | Avid Pro Tools | Avid Technology |
| .RF64 | Radionomy | Zvukové soubory | Winamp RIFF64 Broadcast Wave Format | Nullsoft Winamp | Nullsoft |
| .RFL | Propellerhead | Zvukové soubory | Reason ReFill Sound Bank File | Reason | Propellerhead |
| .RFM | Beatnik | Zvukové soubory | Rich Music Format File | Unknown Software | Unknown Developer |
| .RG | Open Source | Zvukové soubory | Bitmap Picture File | IrfanView | Open Source |
| .RGP | RealNetworks | Zvukové soubory | RealArcade Game Package | RealArcade | RealNetworks |
| .RHL | Edge Sounds, LLC | Zvukové soubory | EdgeSounds RatHole Audio File | RatHole | Edge Sounds, LLC |
| .RIP | IBM | Zvukové soubory | Lotus Notes Error File | IBM Lotus Notes | IBM |
| .RIX | RIX SoftWorks, Inc. | Zvukové soubory | ColoRIX Image File | ColoRIX | RIX SoftWorks, Inc. |
| .RMA | RealNetworks | Zvukové soubory | RealMedia Audio Data | RealPlayer | Realtime Technologies |
| .RMF | Valve | Zvukové soubory | Hammer Rich Map Format | Valve Hammer Editor | Valve |
| .RMI | Open Source | Zvukové soubory | RMID MIDI File | Microsoft Windows Media Player | Microsoft Corporation |
| .RMID | FMJ-Software | Zvukové soubory | RIFF RMID Midi Format | Awave Studio | FMJ-Software |
| .RMJ | RealNetworks | Zvukové soubory | Real Media Jukebox Audio File | NCH Switch | NCH Software |
| .RMM | RealNetworks | Zvukové soubory | RAM Meta File | Media Player Classic | Open Source |
| .RMX | RealNetworks | Zvukové soubory | RealJukebox Format | RealPlayer Cloud | RealNetworks |
| .RNG | Nokia | Zvukové soubory | Nokia Composer Ringtone | Nokia PC Suite | Nokia |
| .RNS | Propellerhead | Zvukové soubory | Reason Song File | Reason | Propellerhead |
| .ROL | Ad Lib, Inc. | Zvukové soubory | Adlib Synthesized Instrument | Nullsoft Winamp | Nullsoft |
| .RPP | Cockos Incorporated | Zvukové soubory | REAPER Project | REAPER | Cockos Incorporated |
| .RRSE | Gryphonclaw Software | Zvukové soubory | REALrunner Lite Sound Effect | REALrunner Lite | Gryphonclaw Software |
| .RSF | EaseUS | Zvukové soubory | Recovery State File | Data Recovery Wizard | EaseUS |
| .RTA | Adobe Systems Incorporated | Zvukové soubory | RoboHelp RTA Data File | Adobe RoboHelp | Adobe Systems Incorporated |
| .RTI | Interscape | Zvukové soubory | Real Tracker Instrument File | Real Tracker | Unknown Developer |
| .RTM | Unknown Developer | Zvukové soubory | Real Tracker Module | Real Tracker | Unknown Developer |
| .RTS | Heaventools Software | Zvukové soubory | Resource Tuner Console Script | Resource Tuner Console | Heaventools Software |
| .RTSP | Apple | Zvukové soubory | Apple QuickTime Real-Time Streaming Protocol File | Apple QuickTime Player | Apple |
| .RVX | RealNetworks | Zvukové soubory | Real Protected Video File | RealPlayer Cloud | RealNetworks |
| .RX2 | Propellerhead | Zvukové soubory | ReCycle Loop File | Avid Pro Tools | Avid Technology |
| .RZR | Eugene Roshal | Zvukové soubory | Renamed WinRAR Archive | WinRAR | Eugene Roshal |
| .S1A | Oracle Corporation | Zvukové soubory | Sealed Acrobat Document | Unsealer | Oracle Corporation |
| .S1M | Yamaha Corporation | Zvukové soubory | Yamaha EX5 Waveform Data | Awave Studio | FMJ-Software |
| .S1Y | Yamaha Corporation | Zvukové soubory | Yamaha EX-series Synthesizer Internal Voice And Performance Data | Unknown Software | Unknown Developer |
| .S3I | Open Source | Zvukové soubory | Scream Tracker 3 Instrument | Scream Tracker 3 | Future Crew |
| .S3M | FMJ-Software | Zvukové soubory | S3M | ModPlug Player | Open Source |
| .S3Z | Future Crew | Zvukové soubory | Compressed Scream Tracker 3 Module | ModPlug Player | Open Source |
| .S48 | Jutel | Zvukové soubory | Jutel RadioMan MPEG2 Audio | Jutel RadioMan | Jutel |
| .S7 | Avid Technology | Zvukové soubory | Sibelius Music Notation | Avid Sibelius | Avid Technology |
| .SA2 | Nullsoft | Zvukové soubory | Suprise! Adlib Tracker Music Module | Nullsoft Winamp | Nullsoft |
| .SAF | DeLorme | Zvukové soubory | Street Atlas USA Map File | DeLorme Street Atlas USA | DeLorme |
| .SAG | Sagem Communication (SAFRAN Group) | Zvukové soubory | Sagem Ringtone Format | Unknown Software | Unknown Developer |
| .SAP | Atari Corporation | Zvukové soubory | Atari SAP Music File | Nullsoft Winamp | Nullsoft |
| .SB | MIT Media Lab | Zvukové soubory | Scratch Project File | MIT Scratch | MIT Media Lab |
| .SBG | Open Source | Zvukové soubory | SBaGen Binaural Beat File | SBaGen | Open Source |
| .SBI | Creative Technology Ltd. | Zvukové soubory | Sound Blaster Instrument | Virtual Sound Blaster | Creative Technology Ltd. |
| .SBK | SwishZone | Zvukové soubory | SWiSH Project Backup File | SWiSH Max | SwishZone |
| .SBM | Keen Software House | Zvukové soubory | Space Engineers Mod File | Space Engineers | Keen Software House |
| .SC2 | EA Maxis | Zvukové soubory | SimCity 2000 City File | Maxis SimCity 2000 | EA Maxis |
| .SD | Various Developers | Zvukové soubory | Sound Designer Audio File | Awave Studio | FMJ-Software |
| .SD2 | Avid Technology | Zvukové soubory | Sound Designer II File | Apple iTunes | Apple |
| .SD2F | Avid Technology | Zvukové soubory | Sound Designer II File | Apple iTunes | Apple |
| .SDK | Autodesk, Inc. | Zvukové soubory | AutoSketch Drawing | AutoSketch | Autodesk, Inc. |
| .SDP | Oracle Corporation | Zvukové soubory | StarOffice Presentation File | Apache OpenOffice | Apache Software Foundation |
| .SDS | Oracle Corporation | Zvukové soubory | OpenOffice.org Chart | Apache OpenOffice | Apache Software Foundation |
| .SDT | Intuit, Inc. | Zvukové soubory | QuickBooks Data File | Intuit QuickBooks Pro | Intuit, Inc. |
| .SDV | Pinnacle Systems Inc. | Zvukové soubory | Studio DV Project File | Pinnacle Studio | Corel |
| .SDX | Kivuto | Zvukové soubory | Kivuto Secure Download Manager File | Kivuto Secure Download Manager | Kivuto |
| .SEG | SEG (The Society of Exploration Geophysicists) | Zvukové soubory | SEG-2 Data File | Unknown Software | Unknown Developer |
| .SEQ | PG Music Inc | Zvukové soubory | PowerTracks Pro Audio Project File | PowerTracks Pro Audio | PG Music Inc |
| .SES | Adobe Systems Incorporated | Zvukové soubory | Audition Session File | Adobe Audition | Adobe Systems Incorporated |
| .SE_ | Cakewalk, Inc. | Zvukové soubory | CakeWalk Pro Compressed Audio File | Cakewalk Pro | Cakewalk, Inc. |
| .SF | Institut de Recherche et de Coordination Acoustique/Musique (IRCAM) | Zvukové soubory | IRCAM Sound File | Awave Studio | FMJ-Software |
| .SF2 | E-mu Systems | Zvukové soubory | SoundFont 2 Sound Bank | Awave Studio | FMJ-Software |
| .SFAP0 | Magix Software GmbH | Zvukové soubory | Sound Forge Pro Audio Proxy File | MAGIX Vegas | Magix Software GmbH |
| .SFK | Magix Software GmbH | Zvukové soubory | Sound Forge Pro Audio Peak File | MAGIX Vegas | Magix Software GmbH |
| .SFL | Magix Software GmbH | Zvukové soubory | Sound Forge Pro Sound Data File | MAGIX Vegas | Magix Software GmbH |
| .SFPACK | Megota Software | Zvukové soubory | Packed SoundFont File | SFPack | Megota Software |
| .SFR | Sonic Foundry | Zvukové soubory | Sonic Foundry Sample Resource File | Awave Studio | FMJ-Software |
| .SFS | Open Source | Zvukové soubory | Squashfs File Archive | 7-Zip | Igor Pavlov |
| .SFZ | Cakewalk, Inc. | Zvukové soubory | SFZ Format File | sforzando | Plogue Art et Technologie |
| .SGW | n-Track | Zvukové soubory | n-Track Studio Packed Song | n-Track Studio | n-Track |
| .SHN | Tony Robinson | Zvukové soubory | Shorten Compressed Audio File | Nullsoft Winamp | Nullsoft |
| .SIB | Avid Technology | Zvukové soubory | Sibelius Score | Avid Sibelius | Avid Technology |
| .SID | Valve | Zvukové soubory | Steam Game Data Backup File | Steam | Valve |
| .SIP | Chris S. Craig | Zvukové soubory | ScopeTrax Compressed Sample File | ScopeTrax | Chris S. Craig |
| .SJ | Blue Ribbon SoundWorks | Zvukové soubory | SuperJAM Audio File | SuperJAM | Blue Ribbon SoundWorks |
| .SLP | Magix Software GmbH | Zvukové soubory | SpectraLayers Pro Project | SpectraLayers Pro | Magix Software GmbH |
| .SLX | MathWorks | Zvukové soubory | MathWorks Simulink Model | Simulink | MathWorks |
| .SLY | GNU Project | Zvukové soubory | Lilypond Guitar File | LilyPond | GNU Project |
| .SMA | Don Ho | Zvukové soubory | C/C++ Source Code File | MacroMates TextMate | MacroMates |
| .SMF | Oracle Corporation | Zvukové soubory | StarMath Formula File | Apache OpenOffice | Apache Software Foundation |
| .SMP | MakeMusic, Inc. | Zvukové soubory | SmartMusic Performance File | SmartMusic | MakeMusic, Inc. |
| .SN | Bluemoon Interactive | Zvukové soubory | Sound Club Editor Compressed Song | Sound Club | Bluemoon Interactive |
| .SN2 | Tom Ehlert Software | Zvukové soubory | Drive Snapshot Second Differential Backup | Tom Ehlert Drive Snapshot | Tom Ehlert Software |
| .SNC | Swiftpage, Inc. | Zvukové soubory | ACT! E-mail/folder Synchronization File | Act! | Swiftpage, Inc. |
| .SND | Open Source | Zvukové soubory | Sound File | Microsoft Windows Media Player | Microsoft Corporation |
| .SNG | Korg | Zvukové soubory | Korg Trinity Song File | Alchemist | SourceForge |
| .SNS | FFmpeg team | Zvukové soubory | SNS Video Game Audio File | FFmpeg | FFmpeg team |
| .SON | Open Source | Zvukové soubory | Notator SL Audio File | Apple Logic Pro | Apple |
| .SONG | Naive Solutions | Zvukové soubory | AudioSauna Song File | Naive Solutions AudioSauna | Naive Solutions |
| .SONIC | Sonic Solutions | Zvukové soubory | DigitalMedia Project File | Roxio Creator NXT Pro 5 | Roxio |
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