| .SAT | Spatial Corp | Soubory CAD | ACIS SAT 3D Model File | Adobe Acrobat DC | Adobe Systems Incorporated |
| .SBL | Adobe Systems Incorporated | Grafické soubory | Shockwave Flash Object | Adobe Flash Player | Adobe Systems Incorporated |
| .SBX | Dream Design Entertainment Software | Komprimované soubory | GLBasic Shoebox File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .SCM | Gimpel Software | Soubory doplňků | GIMP Script-Fu Script | ExtendScript Toolkit (ESTK) | Adobe Systems Incorporated |
| .SCSS | Sublime HQ Pty Ltd | Webové soubory | Syntactically Awesome Stylesheets Syntax Data | Adobe Dreamweaver | Adobe Systems Incorporated |
| .SCT | Scitex | Rastrové obrazové soubory | Scitex Continuous Tone File | Adobe Photoshop | Adobe Systems Incorporated |
| .SD0 | Adobe Systems Incorporated | Soubory Camera Raw | Dali Raw Image | Adobe Lightroom CC | Adobe Systems Incorporated |
| .SD1 | Adobe Systems Incorporated | Soubory Camera Raw | Dali Raw Image | Adobe Lightroom CC | Adobe Systems Incorporated |
| .SEQU | Adobe Systems Incorporated | Soubory nastavení | Adobe Acrobat Sequence File | Adobe Acrobat DC | Adobe Systems Incorporated |
| .SES | Adobe Systems Incorporated | Zvukové soubory | Audition Session File | Adobe Audition | Adobe Systems Incorporated |
| .SESSION | Dassault Systèmes | Soubory 3D obrázků | CATIA 4 Session File | Adobe Acrobat DC | Adobe Systems Incorporated |
| .SGM | VBA Team | Soubory her | VisualBoyAdvance Saved Game | Adobe FrameMaker | Adobe Systems Incorporated |
| .SGML | Corel | Datové soubory | Standard Generalized Markup Language File | Adobe FrameMaker | Adobe Systems Incorporated |
| .SHC | Adobe Systems Incorporated | Datové soubory | Adobe Photoshop Contours File | Adobe Photoshop CC | Adobe Systems Incorporated |
| .SHH | Adobe Systems Incorporated | Soubory nastavení | Adobe Photoshop Shadow/Highlight Settings | Adobe Photoshop CC | Adobe Systems Incorporated |
| .SHTM | Opera Software | Video soubory | HTML Server Side Include File | Adobe Dreamweaver | Adobe Systems Incorporated |
| .SHTML | Sublime HQ Pty Ltd | Webové soubory | Server Side Include HTML File | Adobe Dreamweaver | Adobe Systems Incorporated |
| .SITE | Adobe Systems Incorporated | Webové soubory | GoLive Website Project File | Adobe GoLive | Adobe Systems Incorporated |
| .SIV | Adobe Systems Incorporated | Video soubory | Silicon Imaging Video File | Adobe SpeedGrade | Adobe Systems Incorporated |
| .SKL | Autodesk, Inc. | Soubory 3D obrázků | Maya Skeleton File | Adobe Authorware | Adobe Systems Incorporated |
| .SLDASM | Dassault Systèmes | Soubory CAD | SolidWorks Assembly File | Adobe Acrobat DC | Adobe Systems Incorporated |
| .SLDPRT | Dassault Systèmes | Soubory CAD | SolidWorks CAD Part File | Adobe Acrobat DC | Adobe Systems Incorporated |
| .SMP | MakeMusic, Inc. | Zvukové soubory | SmartMusic Performance File | Adobe Audition | Adobe Systems Incorporated |
| .SND | Open Source | Zvukové soubory | Sound File | Adobe Audition | Adobe Systems Incorporated |
| .SOL | Adobe Systems Incorporated | Soubory nastavení | Flash Local Shared Object File | Adobe Flash Player | Adobe Systems Incorporated |
| .SOR | Adobe Systems Incorporated | Datové soubory | Adobe Flash Media Server File System Object | Adobe Media Server | Adobe Systems Incorporated |
| .SPL | Microsoft Corporation | Systémové soubory | Windows Print Spool File | Adobe Flash Player | Adobe Systems Incorporated |
| .SR2 | Sony | Soubory Camera Raw | Sony RAW Image | Adobe Photoshop | Adobe Systems Incorporated |
| .SRF | NewTek | Soubory 3D obrázků | LightWave Surface File | Adobe Photoshop | Adobe Systems Incorporated |
| .SRW | Samsung Electronics | Soubory Camera Raw | Samsung RAW Image | Adobe Photoshop Elements | Adobe Systems Incorporated |
| .SSI | Adobe Systems Incorporated | Soubory pro vývojáře | Adobe Dreamweaver Server Side Include File | Adobe Dreamweaver | Adobe Systems Incorporated |
| .SSK | Adobe Systems Incorporated | Vektorové obrazové soubory | SmartSketch 95 Document | Adobe Flash Professional CC | Adobe Systems Incorporated |
| .STC | Adobe Systems Incorporated | Webové soubory | Contribute Connection Key File | Adobe Contribute 6.5 | Adobe Systems Incorporated |
| .STD | Oracle Corporation | Vektorové obrazové soubory | Apache OpenOffice Drawing Template | Adobe Acrobat DC | Adobe Systems Incorporated |
| .STE | Adobe Systems Incorporated | Soubory nastavení | Dreamweaver Site Settings File | Adobe Dreamweaver | Adobe Systems Incorporated |
| .STL | 3D Systems | Soubory CAD | Stereolithography File | Adobe Fireworks | Adobe Systems Incorporated |
| .STM | Microsoft Corporation | Datové soubory | Exchange Streaming Media File | Adobe Dreamweaver | Adobe Systems Incorporated |
| .STN | ON1, Inc. | Vektorové obrazové soubory | Genuine Fractals Image | Adobe Photoshop | Adobe Systems Incorporated |
| .STP | Unknown Developer | Soubory 3D obrázků | STEP 3D CAD File | Adobe RoboHelp | Adobe Systems Incorporated |
| .SVG | Nintendo | Soubory her | Saved Game File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .SVGZ | Adobe Systems Incorporated | Vektorové obrazové soubory | Compressed SVG File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .SWA | Adobe Systems Incorporated | Zvukové soubory | Shockwave Audio | Adobe Director | Adobe Systems Incorporated |
| .SWB | Adobe Systems Incorporated | Datové soubory | Adobe Photoshop Data | Adobe Photoshop | Adobe Systems Incorporated |
| .SWC | Adobe Systems Incorporated | Soubory pro vývojáře | Flex Components Archive | Adobe Animate CC 2017 | Adobe Systems Incorporated |
| .SWD | Adobe Systems Incorporated | Soubory pro vývojáře | Flash Debug File | Adobe Flash Player | Adobe Systems Incorporated |
| .SWF | Adobe Systems Incorporated | Video soubory | Shockwave Flash Movie | Adobe Animate CC 2017 | Adobe Systems Incorporated |
| .SWL | Macromedia | Grafické soubory | Alternate Macromedia Flash Format | Adobe Flash Player | Adobe Systems Incorporated |
| .SWT | Adobe Systems Incorporated | Video soubory | Flash Generator Template | Adobe Flash Professional CC | Adobe Systems Incorporated |
| .SWZ | Adobe Systems Incorporated | Webové soubory | Adobe Flash Player Cache File | Adobe Flash Player | Adobe Systems Incorporated |
| .SYN | Image-Line | Zvukové soubory | SimSynth Document | Adobe RoboHelp | Adobe Systems Incorporated |
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