| .EAP | Sparx Systems | Datové soubory | Enterprise Architect Project | Adobe Photoshop CC | Adobe Systems Incorporated |
| .EBX | IBM | Soubory pro vývojáře | Rational Rose 98 Compiled Script | Adobe Creative Suite | Adobe Systems Incorporated |
| .EDB | Microsoft Corporation | Databázové soubory | Exchange Information Store Database | Adobe Photoshop | Adobe Systems Incorporated |
| .EDD | Adobe Systems Incorporated | Datové soubory | Adobe FrameMaker Element Definition Document File | Adobe FrameMaker | Adobe Systems Incorporated |
| .EDL | Avid Technology | Video soubory | Edit Decision List File | Adobe Premiere Pro CC | Adobe Systems Incorporated |
| .EDM | Adobe Systems Incorporated | Soubory pro vývojáře | Adobe Extension Data Markup Language File | Adobe Dreamweaver | Adobe Systems Incorporated |
| .EDML | Adobe Systems Incorporated | Soubory pro vývojáře | Adobe Extension Data Markup Language File | Adobe Dreamweaver | Adobe Systems Incorporated |
| .EDN | Xilinx, Inc. | Soubory CAD | EDIF Implementation Netlist File | Adobe Acrobat DC | Adobe Systems Incorporated |
| .EDT | Adobe Systems Incorporated | Soubory e-knihy | Adobe eBook Download Settings | Adobe Digital Editions | Adobe Systems Incorporated |
| .EMF | Microsoft Corporation | Vektorové obrazové soubory | Enhanced Windows Metafile | Adobe Illustrator CC | Adobe Systems Incorporated |
| .EMZ | Microsoft Corporation | Vektorové obrazové soubory | Windows Compressed Enhanced Metafile | Adobe Illustrator CC | Adobe Systems Incorporated |
| .ENV | Adobe Systems Incorporated | Datové soubory | Adobe Dictionary Data File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .EPR | Adobe Systems Incorporated | Soubory nastavení | Photoshop AME Preset File | Adobe Photoshop CC | Adobe Systems Incorporated |
| .EPS | Adobe Systems Incorporated | Vektorové obrazové soubory | Encapsulated PostScript File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .EPSF | Adobe Systems Incorporated | Vektorové obrazové soubory | Encapsulated PostScript Format File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .EPSI | Adobe Systems Incorporated | Grafické soubory | Adobe Encapsulated PostScript Interchange Format | Adobe Photoshop | Adobe Systems Incorporated |
| .EPT | Adobe Systems Incorporated | Neobvyklé soubory | Adobe Encapsulated PostScript Interchange Format With TIFF Preview | Adobe Acrobat DC | Adobe Systems Incorporated |
| .EPUB | IDPF (International Digital Publishing Forum) | Soubory e-knihy | Open eBook File | Adobe InDesign | Adobe Systems Incorporated |
| .ETD | Adobe Systems Incorporated | Soubory e-knihy | Adobe Reader EBX Transfer Data File | Adobe Acrobat DC | Adobe Systems Incorporated |
| .EXP | Unknown Developer | Soubory pro vývojáře | Symbols Export File | Adobe Acrobat DC | Adobe Systems Incorporated |
| .EXR | Adobe Systems Incorporated | Rastrové obrazové soubory | OpenEXR Image | Adobe Photoshop | Adobe Systems Incorporated |
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